Honza

[Honza @jan_modelar]

@ALLKAResearch This is data from AT-IR (Advanced Therapy Inadequate Response), so patients who previously failed biologics, JAKi, or S1P modulators -> Toughest-to-treat pop with standard toolbox not working. Why would you even use maintenance dose on AT-IR? 25mg 50.8 % remission after week 44

[Honza @jan_modelar]

@ALLKAResearch investigators deemed all 3 non-NMSC cases "unrelated to treatment," NMSC average age 62 vs trial average 42, IDMC adjudication supported safety profile, zero deaths, lower discontinuation on drug than placebo.

[Honza @jan_modelar]

@ALLKAResearch 3/3 Meanwhile, Wk44 maintenance: 51.3% remission, 47.7% endoscopic remission (MES=0), 57.4% HEMI. Non-immunosuppressive. No JAK black box. NDA Q4 2026.

[Honza @jan_modelar]

@ALLKAResearch 2/4 Correct full-population obefazimod 50mg Wk8:
- Clinical remission: 21.7%/19.8% (pbo-adj 16.4% pooled)
- Endoscopic improvement: 33.3%/35.5%

Upadacitinib's own biologic-failure subgroup: ~17.9% clinical remission (Lancet 2022). Gap narrows when you match subgroups properly.

[Honza @jan_modelar]

@Kreuzmann13 Ofc, you should use for example claude code or opencode to help you create some python scripts for that analysis.

[Honza @jan_modelar]

@Kreuzmann13 In your case, try downloading whole fred database and do some statistical data processing on that.

[Honza @jan_modelar]

@CloisterRes No way, most certainly I did not liquidate my position in nktr and move it into abvx June 5th call options. I would most certainly not move it back to nktr on monday neither. 😉

[Honza @jan_modelar]

Anyone interested in trying Opencode Go? I need tokens for my sideprojects and you need them too. So lets both get 5$ for free: Referal: https://t.co/qiU1KcO46m

[Honza @jan_modelar]

@Dr_Moneyball @aggregategains @seedy19tron There was another announcement in the 8k last friday along the new CFO. They can now raise additional 150 milion $ by selling shares at the market price, therefore you as an investor have no incentive to buy until this sell pressure is over.

[Honza @jan_modelar]

@gone1324 $CYTK before 2 am ET

[Honza @jan_modelar]

@levelsio @Marco777Polo You are 20 years too late for that. Todays global average is 430 and in 20 years it will be 500.

[Honza @jan_modelar]

@levelsio @anduriltech if you can’t win the ground war, just program a version where the other side is permanently AFK. I assume next update includes some civilians, power grid and apartment blocks detruction for that authentic 'Special Military Operation' war crime fell.

[Honza @jan_modelar]

@AkciovyGURU Nevidím jednoduchou cestu pro shortaře jak z toho ven. Dva fondy vlastní oklikou přes 100 % akcií, takže záleží jen na nich a na SEC, jak vysoko to chtějí vytáhnout.

[Adam May @A_May_MD]

I mean, come on guys 😅 $NKTR

[Honza @jan_modelar]

@0xMaxFrancoeur Lol, I am not able to reproduce this from SEDI... Are all Canadian public services this cumbersome?

[Honza @jan_modelar]

@StefanWinterToo Wasn't it a bit overcrowded? Everyone I follow on Strava is now on Mallorca.

[Honza @jan_modelar]

@Uzocapital @AboveAvgOdds @HYcorps I smell something fishy. Did not find anything about their product and have not seen any developer/ML guy responsible for the development being mentioned anywhere...

[Jia-Bin Huang @jbhuang0604]

Finally got some time to read the DeepSeek Engram paper!

Idea: Replace repeated reconstruction with direct lookup of common knowledge.

It’s so intuitive that it feels strange this wasn’t part of the design from the start.

Video summary here: https://t.co/bVzOPomJbD