Jan Kössl

[Jan Kössl @JanKossl]

@zacinajicifyzik A clovek se jeste docka vyhruzek nasilim, kontaktovani zamestnavatele nebo obtezovani rodiny. Nedavno jsem si uzil.

[Jan Kössl @JanKossl]

@MiroslavPuza @mestaprolidi @MercuryBarbora Tak můžete dát děti k nám do ČTU, tam to záleží na jednotlivých oddílech. Náš stále na odkazu Setona dost stoji.

[Maxim Artyomov @maxim_artyomov]

Very happy to see cover on Nov 11 @ImmunityCP issue highlighting our review on Human Immune Aging (https://t.co/vCU0OTzID6). One of key visuals highlights major finding made by Terekhova et al in Immunity, 2023 - systematic shift toward type 2 (Th2/Tc2) immunity in healthy aging!

(https://t.co/MnefUu7v6W)

[Alexey Sergushichev @assaron]

I'm happy to present our new web-tool CORESH https://t.co/r1bswFuZXo for searching public gene expression datasets using gene signature as a query, developed by @vd_sukhov, which was just published in @NAR_open https://t.co/PdDMgQz56a 1/n

[Maxim Artyomov @maxim_artyomov]

Just out - our major review piece @ImmunityCP , summarizing couple of decades of the research on human immune aging and providing highlights of the latest advances in the field. Led by Marina Terekhova, truly encyclopedic depth (327 references)
https://t.co/4SenJ8VTOj

[Maxim Artyomov @maxim_artyomov]

#aging #immune_aging
NEW PREPRINT FROM Artyomov&Randolph labs:
How mouse age-associated GZMK+ CD8 Taa cells develop and what are correct surface markers for them
https://t.co/hO0ErccQ51

Among other things we
- Using OT1-Rag2ko mice explicitly show the TCR dependence and yet non-lymphoid origin of these cells(!)
- introduce new genetic model of chronic very low level inflammation that shows the accelerated immune aging in CD8 T cells (dedicated TNFdelta69 deletion generated in Gwen’s Randolph lab).
- find surface marker of the GZMK+ CD8 T cells using newly generated scRNA-seq dataset – in fact these Taa cells are PD1+CD226- CD8 T cells
- find that adipose tissue is one of the key peripheral sites of expansion of Taa cells
- use heterochronic organ transplant of lungs and adipose tissues to prove that it is adipose tissues that drive this development

Read it now, and send us your comments, we are happy to expand and collaborate on these!

[Maxim Artyomov @maxim_artyomov]

latest from our lab:
ITACONATE MECHANISM SOLVED!!

Tom Paulenda @tompaulenda solved molecular mechanism of immunoregulatory action of itaconate in macrophages:
https://t.co/efeSAW4ZTA

Previously, our lab has discovered two major immunoregulatory phenotypes of itaconate in macrophages - enhancement of type I interferon signaling and inhibition of late inflammasome activation (Swain et al, 2020 and Bambouskova et al, 2021). Yet the mechanism of immunoregulation itaconate has been elusive even though we (and others) have previously shown its ability to inhibit Sdh and its mild electrophilic properties.

In the latest work, we believe we have finally cracked that puzzle!!
We show that both immunoregulatory phenotypes are driven by the ability of itaconate to modulate ROS through non-covalent inhibition of the peroxiredoxin 5, mitochondrial peroxide-detoxifying enzyme.
We describe major new phenotypes for the pro-interferon action of itaconate in vitro and in vivo and show that Prdx5 inhibiton is sufficient for immunoregulatory action of itaconate and does not require neither Sdh inhibition nor its mild
electrophilicity.

(1/2)

[Immunity @ImmunityCP]

New issue online! This beautiful cover depicts work from @maxim_artyomov, Pavla Bohacova, Marina Terekhova &co identifying CD38 expression as a marker of recent thymic emigrants. Image credit: Fishy Frog https://t.co/NUVythuEcf

[Jan Kössl @JanKossl]

@JiriParkes1 @D4V1DD0U83K @dostalondrej @DVTVcz To nevyděláte ani stipendiem na PhD “studiu”.

[Jan Kössl @JanKossl]

@njuordr @MSlimakova @eicul @MercuryBarbora Az pujdete nachcipana k lekari, nebo mezi lidi a do mhd, tak si prosim tu rousku nebo lepe respirator vezmete. Diky, nebudte sobec.

[Jan Kössl @JanKossl]

@ricar_marek @Cenazaklid @RomanKratochvl1 @JMagdonova @JaynaKaras Pro vstup do mnoha zemí očkování potřebujete. Pro nástup do zaměstnání (mnoha) také. Bude super to mít konečně digitálně a jednotně.

[Forbes Česko @ForbesCesko]

Na nudu ve vědě zapomeňte. Novým trendem jsou úspěšní kreativci, kteří se orientují ve více oborech. Dokážou se přizpůsobit novým způsobům práce, můžou pak být spokojenější a také lépe placení. #brandvoice #spoluprace
https://t.co/SGMihRXdTz

[Jan Kössl @JanKossl]

@LukasPrajzler @eicul Školil jste někdy někoho? Jakože opravdu, i s tou zodpovědností…

[eLife - the journal @eLife]

A new species of multicellular bacteria found in a cave is giving us clues about how multicellular organisms arise. https://t.co/YV2UIU5xr3

[Jan Kössl @JanKossl]

@Jelinek_K_JUDr @PoliceZPolice @Bikina45073784 @RadanKubant Jojo, protoze za zobacek u cisel je ta buzerace nejsnazsi :) ...

[Jan Kössl @JanKossl]

@ZdenekVrozina @obradam Jsem si ten rozhovor s pani profesorkou musel najit a tahle veta tam zazni v uplne jinem smyslu. Navic, ehm. Prave ta rouska vam treba prave zajisti mensi davku na tu vasi vytouzenou stimulaci a ne rovnou onemocneni ;) Navic IS je stimulovam neustale. Porad. I ted.