Marlene Jara

Data Scientist | My main interests are #parasites, #microbiome and #metabolomics

[GutMicrobiota Health @GMFHx]

Gut microbiome screens could identify risk of Parkinson’s disease years before symptoms appear

A healthy diet was inversely associated with these alterations and might mitigate disease risk

@NatureMedicine 

https://t.co/lY5eWZ1w7B

[🔬 RicardoMontes @_MCRicardo_]

Natural polyphenols in the treatment of inflammatory bowel disease (IBD): pathological intervention activities & delivery system constructions

✅️ Natural polyphenols are bioactive compounds derived from plants, which have shown great potential in the treatment of IBD due to their powerful anti-inflammatory, antioxidant, & immunomodulatory properties.

Highlights:

▶️ Introduces the pathological intervention activities of natural polyphenols in the treatment of IBD.

▶️ Elaborates the applications of natural polyphenols in constructing innovative therapeutic systems for treating IBD.

▶️ Presents the challenges faced by natural polyphenols in drug delivery systems for treating IBD & summarizes the corresponding countermeasures.

https://t.co/YUTxnC04JW @HealthyFellow @_INPST @_atanas_ @DHPSP @drfherediaz @DrGrimaldesJ @LoriShemek @tatiann69922625 @NutrioSci @UsNdHealth

[GutMicrobiota Health @GMFHx]

Human gut microbiome composition shows life stage-specific trends, but develops along distinct trajectories influenced by multiple factors across the life course

This review updates implications for human physiology via @FEBS_Letters: 

https://t.co/A1O0eqhWKm

[🔬 RicardoMontes @_MCRicardo_]

Exercise and the Gut Microbiome: From Mechanisms to Clinical Applications

✅️ Exercise can modify gut microbiota composition and function independently of diet.

✅️ Exercise effects are intensity-dependent, transient, and reversible. Moderate-intensity continuous training reliably increases microbial diversity, enriches health-associated taxa (Akkermansia, Faecalibacterium, Roseburia), and enhances intestinal barrier function. High-intensity interval training acutely perturbs the ecosystem but, following adaptation, stimulates butyrate production through lactate cross-feeding.

https://t.co/LwAnjSGxIG @HealthyFellow
@tatiann69922625 @Mangan150 @_atanas_
Schematic representation of exercise-induced immunomodulation of the intestinal barrier.

Moderate-intensity exercise upregulates tight junction proteins (claudin-1, occludin, ZO-1), reduces pro-inflammatory cytokine expression (TNF-α, IL-1β, IL-6), & increases anti-inflammatory mediators (IL-10, TGF-β). These adaptations limit bacterial lipopolysaccharide (LPS) translocation & attenuate systemic metabolic endotoxemia.

[Digestive Disease Week @DDWMeeting]

Can diet influence Crohn’s disease patterns? 🔬🍬

Research presented at #DDW2026 analyzed a nearly 500 people across Australia and Asia and found that sweeteners - the key food additives studied - such as saccharin, were linked to gut bacteria changes associated with Crohn’s disease. @CUHKofficial

[Marlene Jara @Jara_M]

Impact of Bifidobacterium infantis supplementation on growth, health outcomes, and gut microbiome features in underweight infants from Pakistan.
Great collaboration between Gates Medical Research Institute, Al Shifa Research Centre, and CMbio 🦠🧬
https://t.co/v2BIHLvgG1

[Nature Microbiology @NatureMicrobiol]

Community context reshapes microbial proteomes and reduces functional overlap https://t.co/6Q2gQJ7X8b #MicroSky

[Harry Low’s Lab @thelowlab]

Most bacteria remain uncultured and don’t grow in the lab.. to address this am excited to share EDEN - an enhanced domestication method to grow uncultured bacteria & new diversity. Using EDEN we isolate a new species active against MDR pathogens..

https://t.co/LZ9F4B2aIZ

[Cell Host & Microbe @cellhostmicrobe]

Microbes as architects of colonic patterning

Highlight of @CellCellPress paper discovering regionalization of colonic epithelium depends on microbes, with proximal identity regulated by microbial nicotinic acid-induced PPARα activation in the epithelium.
https://t.co/AX4sPHgVw0

[Microbiome @MicrobiomeJ]

Engraftment of essential functions through multiple fecal microbiota transplants in chronic antibiotic-resistant pouchitis—a case study using metatranscriptomics https://t.co/Koq3toCadr

[DCRjournal @DCRjournal]

#DCRJournal visual abstract recap | Tryptophan Metabolites Improve Intestinal Mucosal Barrier via the Aryl Hydrocarbon Receptor–Interleukin-22 Pathway in Murine Dextran Sulfate Sodium–Induced Pouchitis: https://t.co/OFQGB15KBk

@TAMISYoda @Doc_Brown44 @juliomayol

[Microbiome @MicrobiomeJ]

In #Microbiome

🚨Uncommon bacteria may be a new source of treatments for drug-resistant infection

🔍Employing enrichment cultivation to access antimicrobial peptides encoded by low-abundance bacteria within a marine biofilm community

👉https://t.co/TGvXqol506

[Joana Faria @JoanaRCF]

(7/7) If you want to hear about the messy reality and the "Aha!" moments behind the work, read our Behind the Paper story https://t.co/NJjkaHraoR 
#Parasitology #RNAbiology

[Cell Host & Microbe @cellhostmicrobe]

Weekend read: Catalog of human oral microbiome

Human reference oral microbiome (HROM) comprises 72,641 genomes from 3,426 species, including 2,019 novel species. HROM reveals disease-assoc. species & ectopic oral species in gut predictive of disease
https://t.co/c7YXg3hnhz

[Quanta Magazine @QuantaMagazine]

Meet the ultimate gatekeeper of the nucleus. This molecular machine determines what compounds are welcome inside and which shall not pass. The mechanism behind its selectivity remains a mystery. https://t.co/NOfp9O5Aiu

[Joana Faria @JoanaRCF]

We’re hiring a PDRA and a research technician!
If you’re passionate about #parasites #genomes #condensates then this project is for you! Help us decode the role of nuclear architecture in gene expression regulation in #Leishmania alongside the Mottram Lab @YBRI_UoY @UniOfYork

[Cell Host & Microbe @cellhostmicrobe]

Determinants of FMT success
· cgMLST enables high-resolution strain tracking
· Intra-species dynamics, not species, drive FMT clinical efficacy across diseases
· Conserved ecological strategies govern colonization
· HSIM score predicts therapeutic outcomes
https://t.co/9Lh8YseGdG

[Kiseok (Keith) Lee | kiseokmicro.bsky.social @kiseokmicro]

I think this paper will become a game-changer for studying the microbiome. Matthew Schmitt and I found that a simple neural network, when trained on paired sequencing and functional data, can infer functional group structure directly from data. Preprint -> https://t.co/5gWEO0eKJC

[Cell Host & Microbe @cellhostmicrobe]

Virome regulates nutrient sensing

Enteric virome, dominated by bacteriophages, can autonomously activate host immune signaling to modulate intestinal metabolic responses and regulate carbohydrate digestion & absorption
https://t.co/Lri08t7oaT

[eLife - the journal @eLife]

🧬 A major data reanalysis in December's most-read Genetics paper uncovers thousands of previously hidden protein-coding regions in human and mouse genomes: https://t.co/CiRw4bRmPN