Jay Lu, DPhil

Cardiac Electrophysiology | @MappingLab_EP
#opticalmapping #microelectrodearray #Langendorff
#calcium #actionpotential #heart #AF

[Jay Lu, DPhil @jayjay_lu]

A quick overview of Optical Mapping System for cardiac electrophysiology research.

Effortlessly record cardiac membrane potential and calcium transient.

#opticalmapping #cardiotwitter #Cardiology #arrhythmia #heart @MappingLab_EP

[Jay Lu, DPhil @jayjay_lu]

We are now exhibiting at @ISHR_NAS. Feel free to visit our booth if you re around.

[MappingLab @MappingLab_EP]

A new study shows that inherited arrhythmias like CPVT are not driven by cardiomyocytes (CM) alone.

Using hiPSC-derived neuro-cardiac models, the team found dysfunctional sympathetic neurons can trigger #arrhythmia in otherwise healthy CM.
#electrophysiology #cardiology #mapping

[Jay Lu, DPhil @jayjay_lu]

❤❤❤

[MappingLab @MappingLab_EP]

We are excited to announce the successful installation of our optical mapping system in the laboratory of Prof. Nipavan Chiamvimonvat at the University of Arizona. The system is now fully operational and provides high-resolution, synchronized mapping of cardiac AP and Ca signals.

[MappingLab @MappingLab_EP]

One of the simplest ways to record field potentials and ECG in a Langendorff heart preparation.

Simply apply microelectrode arrays and ECG electrodes directly to the heart.

#CardioTwitter #Electrophysiology #ElectricalMapping #DrugScreening #Cardiotoxicity #iPSC #Heart

[Jay Lu, DPhil @jayjay_lu]

@niels_voigt Great work! 🥂🥂

[Jay Lu, DPhil @jayjay_lu]

Great news! Definitely worth a read. Congratulations!

#mapping #electrophysiology #heart #science

[Jay Lu, DPhil @jayjay_lu]

Great news! Definitely worth a read. Congratulations!

#mapping #electrophysiology #heart #science

[Olu Ajijola MD PhD @OluAjijola]

Thrilled to share our new preclinical paper: low-dose (nonablative) cardiac radiation reduces VT/VF in NICM — associated with improved ventricular conduction and sympathetic nerve distribution.
Grateful for our stellar team: @alicardsdoc @carmenbergom @drlpedersen @doctorphillep @rentschlerlab and first author Devaki Abhyankar.
🔗 https://t.co/9DRC8M9muc
#Electrophysiology #VT #CardioOncology #TranslationalScience @uclahealthnews @jaccjournals

[MappingLab @MappingLab_EP]

The first gene-edited miniature pig model of LQT2 is here.

By combining ECG telemetry, electrical mapping, and optical mapping, this study delivers a truly translational view of hERG-related arrhythmias in a large-animal heart.

Short version:
https://t.co/IHscHiHlvN

[Jay Lu, DPhil @jayjay_lu]

Calcium and Contractility Mapping System: An Integrated Solution for Cardiac Research

https://t.co/r5w1MsZqzu

#Cardiology #cardiomyocytes #ipsc #mapping #calciumimaging #opticalmapping

[MappingLab @MappingLab_EP]

Yu et al. (2025) showed that an Andr-loaded atrial patch prevents POAF by reducing inflammation, oxidative stress, and calcium imbalance. In a rat model, it lowered Afib incidence from 90% to 20% and protected heart cells, highlighting a promising targeted therapy for POAF.

[MappingLab @MappingLab_EP]

Unlock the mysteries of cardiac arrhythmias with our advanced Electrical Mapping System! High precision data acquisition and MEA provide unparalleled insights into electrical activity at the tissue level. Perfect for anti-arrhythmic drug screening and toxicity testing.

[Jay Lu, DPhil @jayjay_lu]

Calcium and Contractility Mapping System: An Integrated Solution for Cardiac Research

https://t.co/r5w1MsZqzu

#Cardiology #cardiomyocytes #ipsc #mapping #calciumimaging #opticalmapping

[Jay Lu, DPhil @jayjay_lu]

Our electrical mapping workflow offers a fast and accessible way to measure epicardial field potentials — ideal for quick assessments in drug testing and disease models. ⚡❤️

#activationmap #electrophysiology #Langendorff #drugscreening #cardiotwitter #Cardiology

[Jay Lu, DPhil @jayjay_lu]

@jerome_montnach @institut_thorax So excited to see more mappers joining the cardiac electrophysiology field. Well done! 🥂🥂

[MappingLab @MappingLab_EP]

Come to join us for exchanging ideas and networking with colleagues and friends.

[Jay Lu, DPhil @jayjay_lu]

@AmandaTong2013 @UTSWMedCenter Great opportunity!

[Jay Lu, DPhil @jayjay_lu]

Excited to share the Langendorff technique for heart cannulation—an excellent method for advancing functional studies 😎

#CardioTwitter #MedTwitter #Langendorff #electrophysiology #heart #Cardiology #opticalmapping #electricalmapping #MEA

[Jay Lu, DPhil @jayjay_lu]

#CalciumImaging #Electrophysiology #OpticalMapping #Contractility #drugscreening #ipsc #cardiomyocyte

[Jay Lu, DPhil @jayjay_lu]

Features:
◉ Precise analysis of Ca waves, transients, E–C coupling, and sarcomere length
◉ >3000 FPS CMOS imaging with 95% QE and <1 e⁻ noise
◉ All-in-one system with dual-dye recording across 400–800 nm.
◉ High-throughput Ca imaging in 10+ cells simultaneously

[MappingLab @MappingLab_EP]

A new video showcasing our Calcium and Contractility Mapping System on iPSC-CMs. It enables simultaneous, high-res measurement of Ca transients and contractility with advanced mapping features.

#cardiomyocyte #singlecell #mapping #calcium #electrophysiology #cardiology #ipsc

[Jay Lu, DPhil @jayjay_lu]

◉ Precise sarcomere length measurement in single cells for detailed analysis of contractile function.