MappingLab

We develop advanced #opticalmapping and #electricalmapping systems to to pinpoint the exact areas of diseased tissue/cells with abnormal electrical conductivity

[MappingLab @MappingLab_EP]

Here is a quick overview of Optical Mapping System for cardiac electrophysiology research.

Effortlessly record cardiac membrane potential and calcium transient.

#opticalmapping #cardiotwitter #Cardiology #arrhythmia #heart
@NikkiPosnack @WenbinLiang2 @brianzahn31 @li_yatong

[Jay Lu, DPhil @jayjay_lu]

Beyond reducing arrhythmias, can a therapy restore cardiac electrical conduction? MEA electrical mapping provides the answer by directly measuring conduction velocity, activation patterns, and electrical heterogeneity.

[MappingLab @MappingLab_EP]

Combining MEA electrical mapping and optical mapping enabled high-resolution analysis of conduction, field potentials, and calcium dynamics in 2D/3D tissues.

[MappingLab @MappingLab_EP]

A new study shows that inherited arrhythmias like CPVT are not driven by cardiomyocytes (CM) alone.

Using hiPSC-derived neuro-cardiac models, the team found dysfunctional sympathetic neurons can trigger #arrhythmia in otherwise healthy CM.
#electrophysiology #cardiology #mapping

[MappingLab @MappingLab_EP]

One of the simplest ways to record field potentials and ECG in a Langendorff heart preparation.

Simply apply microelectrode arrays and ECG electrodes directly to the heart.

#CardioTwitter #Electrophysiology #ElectricalMapping #DrugScreening #Cardiotoxicity #iPSC #Heart

[MappingLab @MappingLab_EP]

It will support precise functional studies in cardiac electrophysiology, enabling detailed investigation of conduction, repolarization, arrhythmia mechanisms, and drug responses.
@jayjay_lu
#Epeeps #electrophysiology #arrhythmias #actionpotential #calcium #Langendorff #Cardiology

[MappingLab @MappingLab_EP]

We are excited to announce the successful installation of our optical mapping system in the laboratory of Prof. Nipavan Chiamvimonvat at the University of Arizona. The system is now fully operational and provides high-resolution, synchronized mapping of cardiac AP and Ca signals.

[The Nobel Prize @NobelPrize]

"I have a very strong belief that we need to keep investing in basic research because of just the nature of science, everything builds on everything else. I think you can't always see the value of something at the time that you're investing in it and working on it."

During our interview with 2025 medicine laureate Mary Brunkow in December, she spoke about the importance of basic research. Stay tuned as her official Nobel Prize interview will be available soon.

Brunkow was awarded the 2025 medicine prize for work concerning peripheral immune tolerance.

[Olu Ajijola MD PhD @OluAjijola]

Thrilled to share our new preclinical paper: low-dose (nonablative) cardiac radiation reduces VT/VF in NICM — associated with improved ventricular conduction and sympathetic nerve distribution.
Grateful for our stellar team: @alicardsdoc @carmenbergom @drlpedersen @doctorphillep @rentschlerlab and first author Devaki Abhyankar.
🔗 https://t.co/9DRC8M9muc
#Electrophysiology #VT #CardioOncology #TranslationalScience @uclahealthnews @jaccjournals

[MappingLab @MappingLab_EP]

Read more: https://t.co/c4onxdQRjv

#cardiotwitter #arrhythmia #electrophysiology #opticalmapping #electricalmapping #MEA #heart #calcium #actionpotential #Cardiology

[MappingLab @MappingLab_EP]

The first gene-edited miniature pig model of LQT2 is here.

By combining ECG telemetry, electrical mapping, and optical mapping, this study delivers a truly translational view of hERG-related arrhythmias in a large-animal heart.

Short version:
https://t.co/IHscHiHlvN

[MappingLab @MappingLab_EP]

#cardiotwitter #Cardiology #arrhythmia #opticalmapping #electricalmapping #MEA

[MappingLab @MappingLab_EP]

In RyR2-R420Q CPVT hearts, subthreshold delayed afterdepolarizations prolonged local repolarization and delayed subsequent activations, increasing ventricular activation dispersion. Optical mapping analyses suggest this mechanism contributes to re-entrant arrhythmia formation.

[MappingLab @MappingLab_EP]

The optical mapping system was used to record calcium transient. The corresponding isochronal maps generated were further translated into key EP parameters by OMapScope, such asconduction velocity, amplitude, and maximum upstroke velocity.

#electrophysiology #cardiology #heart

[MappingLab @MappingLab_EP]

Cai et. al. (2025) developed a human engineered heart tissue model to mimic lipotoxic diabetic cardiomyopathy and found that empagliflozin effectively protects cardiomyocytes by reducing mitochondrial damage, endoplasmic reticulum stress, and apoptosis.

#cardiotwitter

[MappingLab @MappingLab_EP]

Our electrical mapping workflow offers a fast and accessible way to measure epicardial field potentials — ideal for quick assessments in drug testing and disease models. ⚡📷

#activationmap #electrophysiology #Langendorff #drugscreening #cardiotwitter #Cardiology

[MappingLab @MappingLab_EP]

#cardiotwitter #mapping #electrophysiology #Cardiology #microelectrodearray #cardiotoxicity #Langendorff #AtrialFibrillation #science

[MappingLab @MappingLab_EP]

Unlock the mysteries of cardiac arrhythmias with our advanced Electrical Mapping System! High precision data acquisition and MEA provide unparalleled insights into electrical activity at the tissue level. Perfect for anti-arrhythmic drug screening and toxicity testing.

[Jay Lu, DPhil @jayjay_lu]

Calcium and Contractility Mapping System: An Integrated Solution for Cardiac Research

https://t.co/r5w1MsZqzu

#Cardiology #cardiomyocytes #ipsc #mapping #calciumimaging #opticalmapping

[MappingLab @MappingLab_EP]

The optical mapping system was used to record action potential and calcium transient. The corresponding isochronal maps generated were further translated into key EP parameters by OMapScope, such as conduction time, conduction velocity, APD, CTD.
#arrhythmia #electrophysiology

[MappingLab @MappingLab_EP]

Yu et al. (2025) showed that an Andr-loaded atrial patch prevents POAF by reducing inflammation, oxidative stress, and calcium imbalance. In a rat model, it lowered Afib incidence from 90% to 20% and protected heart cells, highlighting a promising targeted therapy for POAF.