John

Fintech, Bioscience Active Listener

[Ricardo @Ric_RTP]

This AI just exposed the BIGGEST legal insider trading operation in America.

A platform called GovGreed built a seven-layer machine learning system that cross-references every stock trade disclosed by every sitting politician against the bills their committees control, the campaign donations they receive, and the companies their votes directly impact.

It scored all 540 politicians currently in Congress. And the numbers are crazy:

56% of every stock purchase made by Congress in the last 16 months was on a stock directly affected by a bill the buyer later voted on. That is 6,170 out of 11,016 total purchases.

More than HALF of all congressional stock buys are on companies whose fate that same politician is about to decide.

343 of 540 Congress members actively trade stocks while holding access to nonpublic legislative information.

That is 63.8% of the entire legislature making market bets with an informational edge that would put any hedge fund manager in prison.

The AI identified 752 active "Triple Signals" in the current Congress. A Triple Signal fires when three conditions line up at once:

The politician sits on the committee controlling a bill, they traded stock in a company affected by that bill, AND they received campaign contributions from that same industry.

Bills carrying these insider indicators pass at 5.4 TIMES the normal rate.

Now look at the individual leaderboard:

- Nancy Pelosi's estimated portfolio sits at $194 million with a Greediness score of 98.1 out of 100
- Ro Khanna made 13,231 trades across 800+ different tickers
- Michael McCaul made 32,302 trades and filed 6,670 of them late
- Thomas Suozzi filed 86.4% of his trades late with an average delay of 396 days, meaning his disclosures landed over a YEAR after he made the trade

And then there is Lisa McClain, the fourth-ranking Republican in the House. She has made 1,443 trades in three years, more than 98% of all politicians tracked.

She violated the STOCK Act twice in a single year, disclosing up to $900,000 in trades months after the legal deadline. Her husband bought up to $250,000 in Elon Musk's xAI, which quietly converted into SpaceX equity before last Friday's $2 trillion IPO.

The penalty for all of this? A $200 fine.

The number of Congress members ever prosecuted under the STOCK Act since it passed in 2012? Zero.

And the cruelest part is this:

A bill to ban congressional stock trading was introduced in January 2026. It has bipartisan support. Over 80% of American voters want it passed.

But Congress is sitting on it, because the people who would have to vote yes are the same people making millions from the system staying exactly the way it is.

They write the insider trading laws, they exempt themselves from enforcement, they trade on the information those laws generate, and when they get caught, they pay a fine that is basically nothing.

The AI didn't discover anything Congress was hiding. It just organized what was already public into a pattern so obvious that nobody can pretend it isn't there anymore.

[John @jbatch4]

@MapleStax Superb strat maple

[BeccaAmilee @BeccaAmilee]

I hope its obvious that by writing, I can process many of my own emotions. I have written 4 equally lengthy posts over the last 2 months that I never felt the need to publish. In retrospect, I think whether I choose to hit publish may be due to whether I need the boost of outreach from you all, or not.

I can't imagine going through this without everyone's words and gestures and flowers and kindness and prayers. It would be pure despair. Thank you for all the energy you spare me, in any form. It keeps me going from day to day.

Back to the war, today. Let's get it.

[Yair Einhorn @yaireinhorn]

@PrimeMedicine If you found my🧵interesting please share, retweet or Bookmark it so that those on @X who are interested in Gene editing, CRISPR, BioTech and Genomics will be able to access this resource and as always I would be more than happy to read your thoughts. $XBI $PRME

[Michael Saylor @saylor]

I think https://t.co/meaZhpFNq9 needs even more green dots.

[industry s5 awards campaign manager 🍉 @itweetabttv]

LMAOO TIMOTHEE CHALAMET ACTUALLY SHOWED UP TO THE TIMOTHEE CHALAMET LOOKALIKE CONTEST IN WASHINGTON SQUARE PARK

[Austin Campbell @austincampbell]

I know this will not be a popular statement for the crypto community, but right now the potential benefits of this are purely theoretical. As someone who helped clean up the financial crisis of 2008 (and, hilariously, was in a recruiting event for Lehman the week before they went bankrupt - true story!), there are elements of what blockchain can bring that would help:

Transparency
Elimination of counterparty credit risk for spot trades
Reduced influence of intermediaries and custodians

However, most (all?) of those benefits remain theoretical. If we look at what blockchain has actually done so far:

Created far more opaque and centralized entities than anything that exists in traditional finance (CEXs, which combine the exchange, custodian, and clearing agent role into a single object with the informational density of a black hole, leading to things like FTX)

Introduced massive amounts of credit risk through the opacity of most protocols, which has caused a proliferation of scams, hacks, and just basic failures that could have been avoided

Been completely unusable and not understandable to the average user, increasing the power of some forms of intermediaries

None of this is good! It's like a bunch of angry toddlers ran off to build their own financial system in response to 2008 sometimes. Now the room is covered in pasta, there are lego blocks all over the floor, and there's a lot of crying and throwing things. This is not an improvement.

I am still very long the technology and the potential to build things with it, but the supermajority of what has been built so far is not usable, and the industry needs to greatly, greatly, greatly improve its risk management, transparency, and operational practices before it can or should be taken seriously by anyone as a real option.

[Kevin W. @Brink_Thinker]

This is Stancy Cardwell. He stormed the beaches of Normandy carrying a 60mm Mortar. He’s 101 years old and deserves endless retweets 🇺🇸

[Andrew Beggs @adbeggs]

Well here is the EGFR:c.2235_2249del,p.Glu746_Ala750del mutation present at **2%** in this sample - as you can see it is there in the super accuracy called sample, but clear as day in the duplex sample

[Justin Donnelly ⌬ @drjdon]

@CarolynBertozzi serving science queen sparkle realness at the Nobel ceremony. An elegant but elevated look befitting Chemistry’s first queer laureate - absolute 🔥. 10/10.

[Ashraf Saad, bridging Glycobiology and Oncology! @AsAshraf123321]

#glycotime
As abnormally glycosylated glycoproteins are specific to tumor cells, they offer unique targets for CAR T therapy!
Excellent review on CAR T cells for solid tumors by Zoe Raglow,Mary Kathryn McKenna,Malcolm K. Brenner,David M. Markovitz &others.
https://t.co/rUoAJqROL8

[Bruce Booth @LifeSciVC]

Another lentiviral gene therapy delivering strikingly positive data in rare diseases... $RCKT's LAD-1 data... Despite sentiment against gene therapy these days, lentiviral Rx remain a powerful modality for delivering durable potential cures $RCKT
https://t.co/HdWi7lEXQd

[Hui Jing @huijing_1]

Congratulations to the 2022 Wolf Prize Chemistry Laureates @WolfPrize_ Prof. Benjamin Cravatt, Prof. Bonnie Bassler and Prof. Carolyn Bertozzi @CarolynBertozzi !

[Mia Huang 黃雪兒 @HuangMia]

Congratulations to the 2022 Wolf Prize in Chemistry recipients! #bonniebasler @CarolynBertozzi #bencravatt

[Bloomberg Opinion @opinion]

Most banks have the wrong strategy, the wrong structure and usually too much legacy baggage to develop new technology https://t.co/Wl96GrSVPn

[J. Am. Chem. Soc. @J_A_C_S]

O-Glycosylation Induces Amyloid-β To Form New Fibril Polymorphs Vulnerable for Degradation @Amyloid @Polymorphs https://t.co/KGwhHQiLes

[Will Barr @will_barrcode]

Was curious what AlphaFold would predict about the #Omicron RBD. The top ranked structure was within 1-3 Å of deposited alpha RBDs and within resolution of a @bjorkmanlab @NussenzweigL structure (6XCM) bound to a human mAb

[Dr. Carolyn Cummins @CarolynLCummins]

An absolute pleasure to hear @CarolynBertozzi present her lab’s work on sialoglycans and contrast with checkpoint inhibitors. It was SO easy to follow- outstanding job. 🙏👩‍🏫#PRiME2021

[Jens Nordvig @jnordvig]

Is it a coincidence that bitcoin has broken $50K at the same time as the news media is full of stories about a potential US default as a function of failure to raise the debt ceiling in October?

The chart shows that $BTC (white) spiked exactly as US T-bill yields (yellow) spiked