Journal of Cell Biology

The Journal of Cell Biology (JCB) publishes peer-reviewed research on all aspects of cellular structure and function. Est. 1955 - @RockUPress

[Journal of Cell Biology @JCellBiol]

Endo, Saeki, Komada et al. demonstrate that USP8 is a gatekeeper of misdirected #ubiquitin signals to prevent immune and stress responses. https://t.co/fd7ywbiKO8

📕 In #Lysosomes 2026: https://t.co/svh5PGFfHb

[Journal of Cell Biology @JCellBiol]

Hämälistö, Del Valle Batalla, @LabYuseff, and @mattilalab review how #BCells have adopted specialized ways to use endolysosomal vesicles to promote adaptive immune responses. https://t.co/utTYS8Vxut

📕 In #Lysosomes 2026: https://t.co/cmsYzG94ON

[Journal of Cell Biology @JCellBiol]

.@Rachid_Thiam and Carpentier review seipin's role in directing lipid fate, proposing it as a multinode rheostat that manages PA, ceramide, and Ca²⁺ flux at organelle contact sites to control metabolic branchpoints. https://t.co/Kfa2pTJejb

#LipidDroplets #LipidMetabolism

[Journal of Cell Biology @JCellBiol]

J Winter, @jclandoni, @SulianaManley, @eKoslover, Holt et al. reveal that perinuclear #mitochondria form a source population, w/ biased anterograde transport spreading material to maintain network connectivity & balanced mitochondrial mass across the cell. https://t.co/0V4FgA8opx

[Journal of Cell Biology @JCellBiol]

Excessive STAU1 condensate drives #mTOR translation and #autophagy dysfunction in #neurodegeneration. From Ruiqian Zhao, Wenyu Wen and colleagues: https://t.co/678C5AtEbJ

📕 In #Lysosomes 2026: https://t.co/vzFhPO7w6A

[Suhong Xu @SuhongXu_ZJU]

It is unexpected for us to find this protein, MAI-1, which turns out to be important in sensing and detecting mitochondrial membrane damage.

[Journal of Cell Biology @JCellBiol]

Shi, Manzi, Grater, Kopparapu, Ohler, de Jesus, & Dickinson show that in polarizing epithelial spheroids from mouse embryonic #StemCells, ZO-1 clusters are transported by cortical #actin flows to establish the apical junction. https://t.co/PyIDHpFhUk

#Myosin #Cytoskeleton

[Journal of Cell Biology @JCellBiol]

Fujimoto & Tamura show that glucose starvation remodels the yeast nucleus–vacuole junction via Ypf1 and INSIG homologs, Nsg1 and Nsg2, pointing to a role for fatty acid elongation-linked membrane remodeling in the spatial control of ergosterol biosynthesis https://t.co/XcNPqJgakH

[Journal of Cell Biology @JCellBiol]

How do cells recognize catastrophically damaged #mitochondria? Gao et al. identified MAI-1, the first genetically encoded reporter of severe mitochondrial membrane damage. This cytosolic protein translocates to damaged mitochondria within milliseconds. https://t.co/BwWtlgDepD

[Journal of Cell Biology @JCellBiol]

The endolysosomal system in conventional and unconventional protein #secretion. A Perspective by Eloïse Néel, Marioara Chiritoiu-Butnaru, Julien Villeneuve and colleagues: https://t.co/OmCv5mrh8U

📕 In #Lysosomes 2026: https://t.co/VwVf6D229R

[Journal of Cell Biology @JCellBiol]

Kristina Sakers, @c_eroglu et al. report that astrocytic neuroligins are functionally diverse proteins with unique intracellular protein–protein interactions. In vivo, ubiquitination of NL2 by Nedd4l is critical for #astrocyte #morphogenesis. https://t.co/vJBZfGlDfn
#Neuroscience

[Journal of Cell Biology @JCellBiol]

Heterogeneity of late #endosome/#lysosomes shown by multiplexed DNA-PAINT imaging. Quantitative pipeline developed by Charles Bond, Melike Lakadamyali @melikel.bsky.social and colleagues: https://t.co/faWYw7ywXu

📕 In #Lysosomes 2026: https://t.co/upA8Bh2oHE

[Journal of Cell Biology @JCellBiol]

Our June issue is here! https://t.co/nbgzWZhbce
The cover shows a maximum intensity projection from a confocal image stack showing an angiogenic sprout emerging from an engineered microvessel. From Lakyn Mayo, Matthew Kutys et al.: https://t.co/F3312MT83B

[Journal of Cell Biology @JCellBiol]

Wu and Hegde annotate & analyze the topology of 4,863 human endoplasmic reticulum–inserted membrane proteins & their 20,546 transmembrane domains, showing transmembrane domains inserted by different pathways can tolerate different biophysical properties https://t.co/PUO8qu4UWu

[Journal of Cell Biology @JCellBiol]

PINK1 controls RTN3L-mediated ER #autophagy by regulating peripheral tubule junctions. From Ravi Chidambaram, Kamal Kumar, Susan Ferro-Novick and colleagues: https://t.co/olJDGIkrvp

📕 In #Lysosomes 2026: https://t.co/fykRThXAgY

[Journal of Cell Biology @JCellBiol]

Any1 is a #phospholipid scramblase involved in #endosome biogenesis. From Jieqiong Gao, Christian Ungermann and colleagues: https://t.co/nBhHMI0Ihi

📕 In #Lysosomes 2026: https://t.co/4ANhoABM3P

[Journal of Cell Biology @JCellBiol]

Hayase et al. show that E-cadherin promotes bile canaliculus elongation via RhoA activation and oriented cell division, while N-cadherin maintains hepatic #polarity by attenuating RhoA, defining distinct roles of dual #cadherin expression in #hepatocytes. https://t.co/82NZAa00Do

[Journal of Cell Biology @JCellBiol]

Sorting nexin 10 regulates lysosomal ionic homeostasis via ClC-7 by controlling PI(3,5)P2. From Jing Ze Wu, Sergio Grinstein, Spencer Freeman @spencerfreeman.bsky.social and colleagues: https://t.co/4CZY4tWFyx

📕 In #Lysosomes 2026: https://t.co/eOju8D3Ts8

[Journal of Cell Biology @JCellBiol]

Read An interkinetic envelope surrounds chromosomes between #meiosis I and II in #Celegans oocytes https://t.co/DQJfEYlm6j

[Journal of Cell Biology @JCellBiol]

“Thank you, JCB, for upholding such high standards!” — Julien Dumont. Share your breakthroughs with a global audience. Learn more. https://t.co/X3lCqrzD11