Jim Vine

Data research @usociety, @iseressex, @Uni_of_Essex. Views are my own; RT does not imply endorsement.

[Jim Vine @jim_vine]

'Standardising Standards', in which I make the case for shared standards in the evidence sector, has now been published by @A4UEvidence https://t.co/H9oRxbZt49

[Jim Vine @jim_vine]

@kareem_carr Not a million miles from something Archie Cochrane did IRL. Compared early Coronary Care Units to home care, found home care was better... but pretended vice versa when first presenting findings to cardiologists. See pp12-13 of this by @bengoldacre https://t.co/JFhSbcuJ7b

[Jim Vine @jim_vine]

@jeanmadams There's a mnemonic if you remember the story of the Boy Who Cried Wolf! https://t.co/HcTANY85w7

[Justin Wolfers @JustinWolfers]

Never confuse Type I and Type II errors again, thanks to the boy who cried wolf.

[Jim Vine @jim_vine]

@DrNeilStone Again, it's not proof. It's not certainty. But it seems like it's some evidence that this might escape the vaccines' protections. 4/4

[Jim Vine @jim_vine]

@DrNeilStone And the experts in South Africa have described the large number of mutations in this variant, including related to the spike that the vaccines train our immune systems to look for. 3/

[Jim Vine @jim_vine]

@Work_Life_You @xandvt @SarahWaygood @DoctorChrisVT Their Operation Ouch! special on puberty is incredibly well done, if that's of any help. https://t.co/MR8fL9jalV

[Jim Vine @jim_vine]

@Bob_Wachter Great to see the mention of 'testing to be sure'. I've just done a thread crunching some numbers re the UK situation, where the schedule has been switched to 12wks between doses after @hildabast mentioned schedule randomisation. https://t.co/zmqBxH14tN

[Jim Vine @jim_vine]

@hildabast @AW50968253 Thinking about this some more, it seems to me like we could get really robust answers on this with about 1 week's worth of randomisation. I'll show my working, though my numbers are necessarily hand-wavey. 1/n

[Jim Vine @jim_vine]

@Cathari18465929 Hi from Essex!

[Jim Vine @jim_vine]

@Cathari18465929 @hildabast @AW50968253 There's a graph with some numbers that might answer your query, about 1/2 way down this article from a few weeks back:
https://t.co/jOcKa14xKX

[Jim Vine @jim_vine]

@hildabast @AW50968253 As I say, this is not my area of subject matter expertise so may be wrong in important ways. But it's interesting to crunch the numbers and get a sense that generating lots of evidence on the best schedule seems well within reach given large roll-outs imminently. 29/fin

[Jim Vine @jim_vine]

@hildabast @AW50968253 And people who opt to be randomised into different schedules (vs., presumably, non-consenting people having the JCVI 12 week default schedule) could be different in important behavioural ways, so would generate evidence that's less generalisable to population. 28/n