Jeffrey Noel

Biophysicist interested in all things protein. How fast can you fold a protein?

[Jeffrey Noel @jknoel]

Our work on how the dynamin machine constricts membrane tubes is out in PNAS: https://t.co/VkYNh4UEfK. Great collaboration with @hofmann_hagen .

[George Heath @George_R_Heath]

🎉Delighted to share our work out in @Nature today 🎉 using Super-Resolution Localization methods to increase #AFM resolution beyond the limits set by tip radius, reaching at least 4Å resolution. Huge thanks and brilliant working with @ScheuringLab 🙏
https://t.co/bq3djMG0UY

[Jeffrey Noel @jknoel]

@cmatthaeus2 I love that the gif continues until the ball hits ceres, very satisfying

[Jeffrey Noel @jknoel]

@cmatthaeus2 Thanks Claudia! It is a lot of fun so far. On the train to Amsterdam right now 🙂...😷

[Jeffrey Noel @jknoel]

I recently switched my day job from academia to a small modeling company https://t.co/hbBl7oDuyg and we are searching for another molecular modeler: https://t.co/pkhdyoA1ck

[Jiwei Liu @Jiwei_Liu_lab]

Our bacterial ESCRT-III paper is online (https://t.co/jgWAjyJZ6b)! Congratulations and big thanks to @thelowlab @lab_baum @BaumBuzz @Matteo_tassina @souvik_naskar @diorge_souza @jknoel and all authors!

[Jeffrey Noel @jknoel]

@cmatthaeus2 Very beautiful Claudia! Do you think you can ever see dynamin, or will it always be obscured by the clathrin coated vesicle??

[The Royal Society @royalsociety]

#OnThisDay in 1977, NASA launched the Voyager 1 probe on its journey to study the outer solar system. After 42 years of operation, the probe is still transmitting data, and at over 13.9 billion miles from Earth, is the most distant man-made object from work. #SpaceExploration

[Jeffrey Noel @jknoel]

@RouxLab I agree, the 2016 review nicely laid out the open questions. It is important to say that our work isn't simply a visualization, but rather a demonstration based on a quantitative framework containing the ligand kinetics, motor forces and membrane elasticity

[Jeffrey Noel @jknoel]

I am excited to share our new @biorxivpreprint on the function of the dynamin motor, a helical-filament-forming GTPase that catalyzes membrane scission in endocytosis. We show how the collective behavior of the individual motors leads to constriction: https://t.co/wEfxI9X5xC

[Hagen Hofmann 🎗️🇮🇱 @hofmann_hagen]

REMINDER: The PROTEIN FOLDING AND DYNAMICS webinar is back online tomorrow Mo. 15:00 UTC with Taekjip Ha! Don’t miss it! Zoom link: https://t.co/QlPzDPfbuL

[Jeffrey Noel @jknoel]

Finally, a cool result explaining why scission is observed at the ends of long dynamin filaments. In addition to the membrane curvature effects described by @RouxLab (Morlot et al. 2012 Cell), constriction is only efficient at the ends, where the motor forces are unbalanced.

9/9

[Jeffrey Noel @jknoel]

In many scenarios the constriction produced by motor activity is already enough to enable spontaneous hemifusion. An important parameter is the motor duty ratio: the fraction of time each motor module spends in a force-producing dimer.

8/N

[Diorge Souza @diorge_souza]

Happy to share our preprint on the structure of Vipp1 and why we believe Vipp1/PspA/Im30 proteins are ESCRT-III homologues, based on primary, secondary, tertiary and quaternary structural similarities. And my first scientific thread! https://t.co/krQX1xyOQq