Jörgen Kornfeld

Neuroscience, Connectomics & Connectome decoding, Machine learning, Research Group Leader @MRC_LMB @MPIforBI, co-founder of

[bioRxiv Neuroscience @biorxiv_neursci]

The songbird basal ganglia connectome https://t.co/YzswTw0wIO #biorxiv_neursci

[Jörgen Kornfeld @jmrko]

PRISM has the potential to solve the proofreading challenge of connectomics for good - fantastic collaboration with E11, MIT, and the Crick!

[Andrew Payne @Andrew_C_Payne]

@E11BIO is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. We discovered a new cell barcoding approach exceeding comparable methods by more than 750x. This is the heart of PRISM. We integrated this capability with microscopy and AI image analysis to automatically trace neurons at high resolution and annotate them with molecular features.

This is a key advance towards economically viable brain mapping - 95% of costs stem from neuron tracing. It is also an important step towards democratizing neuron tracing for everyday neuroscience. Solving these problems is critical for curing brain disorders, building safer and human-like AI, and even simulating brain function.

In our first pilot study, we acquired a unique dataset in mouse hippocampus. Barcodes improved the accuracy of tracing genetically labelled neurons by 8x – with a clear path to 100x or more. They also permit tracing across spatial gaps – essential for mitigating tissue section loss in whole-brain scaling. Using molecular annotation, we uncover an intriguing feature of synaptic organization, demonstrating how PRISM can be used for systematic discovery 🧵

[Jörgen Kornfeld @jmrko]

💀 Spent hours doing email archaeology? Same.
So I built NeuralMail 📨:
🔓 Open-source
🔑 IMAP (works w/ Gmail, Outlook, etc.)
🤖 Bring your own LLM
⚡ Digs thru 100k+ emails + attachments
https://t.co/Q7u1OTpqsh
#NoMoreEmailArchaeology

[Waggoner Lab @LabWaggoner]

Brain tissue artificially expanded to show how neurons wire together @Nature @JGDanzl @RTMojtaba
https://t.co/1EGufOuNnc
@NatureNV @jmrko
https://t.co/xPo3WMOYRe

[Convergent Research @Convergent_FROs]

🚀 Calling all visionary scientists and engineers! Announcing our call for Focused Research Organization proposals in the UK. 🔬Submit your concept paper by Feb 7 & full proposal by March 28. ⤵️

[Andrew Payne @Andrew_C_Payne]

E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains. 1/N 🧵

[David A. Markowitz @DavidAMarkowitz]

The $3B Human Genome Project was started under a Republican administration and later acknowledged by the Obama admin to have returned $141 to the economy for every $1 spent. Science has a higher ROI than any other category of government spending.

[Jörgen Kornfeld @jmrko]

Interested in working on a state-of-the-art connectomics pipeline at its birthplace as a postdoc? We’d love to hear from you! :)

https://t.co/RkhoxzuJqE

[Jörgen Kornfeld @jmrko]

Interested in working on a state-of-the-art connectomics pipeline at its birthplace as a postdoc? We’d love to hear from you! :)

https://t.co/RkhoxzuJqE

[Franz Rieger @rieger_fr]

🧠 In #connectomics, artificial neural networks analyze biological ones, but large-scale benchmarks have been lacking. We introduce NISB - the Neuron Instance Segmentation Benchmark, generated with novel 3D diffusion models!
1/2

[Greg Jefferis @gsxej]

Big day for neuroscience & the end of the beginning for whole brain connectomics. Shout out to @sdorkenw and Philipp Schlegel, first authors of the connectome papers, @MurthyLab @SebastianSeung for establishing #flywire to make this possible and @dddavi for birthing this dataset.

[Sven Dorkenwald @sdorkenw]

Incredibly proud and grateful to be part of the #FlyWire team that made this happen. This was an immensely collaborative project - on every level from early open data sharing, to tool building, to analysis - over many years, across many institutions. It's been a fantastic journey

[MPI for Biological Intelligence @MPIforBI]

🚨🎓 New application round: Join us in researching the multiple facets of biological intelligence and become a PhD student at our fully funded graduate school IMPRS-BI in the Munich area!

🔔 Application period: October 1 to November 10
🌐 Apply here: https://t.co/wdQLGzoLz3

[Max Planck Society @maxplanckpress]

Calling all emerging scientists - it’s time to send us an application! 😉😎 Lead your own #MaxPlanck Research Group w/ €2.7M in funding over 6 yrs, full independence & resources to hire staff. State-of-the-art infrastructure awaits you!🌟 Apply today➡️https://t.co/cHxPLyRj9x

[Jörgen Kornfeld @jmrko]

Fascinated by the idea of decoding memories from connectomes? Interested in working on a cutting-edge connectomics pipeline? Excited about high-throughput data acquisition or machine learning? We're hiring postdocs, PhD students, and technicians! Reach out :)

[Jörgen Kornfeld @jmrko]

@AdamMarblestone @CJHandmer This looks indeed like a problem the connectomics folks have solved.... @CJHandmer feel free to reach out!

[Srini Turaga @srinituraga]

Our collaboration with @GoogleDeepMind has borne fruit! Or rather, a fruit fly 🪰🙂
Simulated with #MuJoCo physics, trained with imitation learning, capable of realistic locomotion, both on the ground and in the air. 1/n
https://t.co/J8oB8zyezH
https://t.co/78OYE8K1en