Jon Hacker

Building ultrasound neuromodulation

Mission: Liberate Human Consciousness.

[Jon Hacker @Jon_The_Hacker]

🧠ZenBud LIFU: 79% anxiety remission in 4 weeks! Peer-reviewed & published in JMIR Neurotechnology.

Non-invasive ultrasound vagus nerve modulation study dropped last night.

Dive in🧵 to see the future of mental health.

[Jon Hacker @Jon_The_Hacker]

From Grok Imagine.

Funny animal, turned into a video

It’s a spicy hamster

Had to share

[Marcus Kaiser @ConnectomeLab]

Are you a registered healthcare professional searching for a PhD position?

Using Zenbud #ultrasound #vagusnerve stimulation (see below), the PhD position with me and Ben Marson is about 'Reducing pain reactivity for children in Emergency Departments'

https://t.co/GZ1M6CcwDg

[NIHR BRC Nottingham @NottmBRC]

Researchers @NottmBRCMRI and @hearingnihr at our BRC are testing a wearable headset device to see if it's suitable to treat medical conditions including anxiety and tinnitus in future. More details here: https://t.co/D2wCX9eesf
@NottmBRCMRI @ConnectomeLab

[Jon Hacker @Jon_The_Hacker]

2am work vibes hit different.

A lot of space for deep work.

[Jon Hacker @Jon_The_Hacker]

@BasedPsychMD Worth checking out vagus nerve stim, I run a company that just released some clinical data in the Anxiety, PTSD, and Depression space

[Jon Hacker @Jon_The_Hacker]

@JellyfishDAO Anyone that’s incentivized (which to some degree we all are) and not burdened by regulations has the best chance.

[Robert Greene @RobertGreene]

If you are unsure of a course of action, do not attempt it. Your doubts and hesitations will infect your execution. Timidity is dangerous: Better to enter with boldness. Any mistakes you commit through audacity are easily corrected with more audacity. Everyone admires the bold; no one honors the timid.

[Jon Hacker @Jon_The_Hacker]

@operationdanish Link to the study?

[Jon Hacker @Jon_The_Hacker]

@thecammyc Founders

[Jon Hacker @Jon_The_Hacker]

@Hitchslap1 Let’s forward down for a moment

[Jon Hacker @Jon_The_Hacker]

@IterIntellectus Morning

[Jon Hacker @Jon_The_Hacker]

@IterIntellectus Danger coffee
ZenBud
Creatine
MCT oil

[Jon Hacker @Jon_The_Hacker]

May the 4th be with you.

[Jon Hacker @Jon_The_Hacker]

@Rainmaker1973 Let’s ensure we make it to 2116 and prove this wrong

[Jon Hacker @Jon_The_Hacker]

💬Let’s Talk
What questions do you have?
What would you like to see in future trials?
Researchers & biohackers your insights matter.
DMs open.

[Jon Hacker @Jon_The_Hacker]

🔬 Research Opportunities
LIFU VNS could help treat anxiety, depression, PTSD & more.
We’re looking for:
• Academic partners
• Neuroimaging collaborators
• Citizen scientists (with rigor)
�� Funders for ZenBud & clinical trials

[Jon Hacker @Jon_The_Hacker]

🤝Collaborate With Us
Want to help build the future of non-invasive neuromodulation?
We’re open to partnerships across disciplines.
Research convos:📩 [email protected]
Business convos:📩 [email protected]

[Jon Hacker @Jon_The_Hacker]

⚠️ Limitations
• Small sample (n=28)
• No control group
• 4-week duration
We need RCTs, longer follow-ups, and parametric tuning.

[Jon Hacker @Jon_The_Hacker]

🧠ZenBud LIFU: 79% anxiety remission in 4 weeks! Peer-reviewed & published in JMIR Neurotechnology.

Non-invasive ultrasound vagus nerve modulation study dropped last night.

Dive in🧵 to see the future of mental health.

[Jon Hacker @Jon_The_Hacker]

🧬 How It Works
The auricular vagus nerve modulates stress via the parasympathetic system.
LIFU may boost vagal tone → reduce anxiety.
Separately we’ve seen HRV gains of 10–27 pts.
Next step: fMRI, HRV, EEG, etc.

[Jon Hacker @Jon_The_Hacker]

🛡️ Safety & Usability
• 1 mild side effect (brief jitteriness)
• 89% rated device easy to use
• 79% said quality of life improved
Low risk, high usability ✅