John Muirhead-Gould

Husband & Father. Solution Architect for HID Global PKIaaS. Founder, Nodes Bio. Maritime OSINT + biotech. Tracking ships is interesting. Proud American. 🇺🇸📡

[John Muirhead-Gould @JonIsGold]

Your DNA breaks 10,000 times a day. You're fine because one protein runs a repair crew that stitches it back perfectly using your backup copy.

When that protein is mutated? Duct tape and prayers.

That's BRCA1. That's the 70% lifetime risk.

[Nodes Bio, Inc. @NodesBio]

Prompt: 'BRCA1 DNA repair pathway'

MedMap generated this in 3 seconds. DSB sensing → ATM/ATR checkpoint activation → BRCA1 phosphorylation → RAD51 loading → homologous recombination. All edges labeled, all interactions typed.

[John Muirhead-Gould @JonIsGold]

Your body has a self-destruct button for broken cells. One protein decides: kill it before it becomes cancer.

Most cancers don't disable the button - they gag the guy whose finger is on it.

That's p53 and MDM2. That's why it's mutated in >50% of all human cancers.

[Nodes Bio, Inc. @NodesBio]

Prompt: "How does p53 regulate apoptosis?"

MedMap generated this in seconds. Both extrinsic (FAS/FADD/CASP8) and intrinsic (BAX/Cytochrome C/Apoptosome) arms, MDM2 feedback loop, BH3-only protein regulation.

https://t.co/D8cObkaUiV

[John Muirhead-Gould @JonIsGold]

The American Dream is alive and well, you just have to work for it! #America250

[John Muirhead-Gould @JonIsGold]

@NFX @omri_drory It's grape seed extract

[John Muirhead-Gould @JonIsGold]

@NFX @omri_drory There's actually a practical answer to this that an acquaintance and I discovered 😀

[John Muirhead-Gould @JonIsGold]

Spent a little time today with my buddy John Finizio optimizing 3D print schedules using a quantum conflict solver on QuEra Aquila, after he kindly printed me a Socrates bust. So cool!

The output is a dodecahedron, a twisted vase, a helix spring, and a torus - and a maximum-weight independent set that tells you which two to print together.

How it arrives at that answer is left as an exercise for the reader. Enjoy!

https://t.co/FJoTDz6IKT

[John Muirhead-Gould @JonIsGold]

For the record...

There are probably only a few thousand people on Earth who know how to invoke applied quantum computing.

Turns out I am one of them 👻!

Someone might care one day.

#QuantumComputing #RareClub

[John Muirhead-Gould @JonIsGold]

Spotted earlier, the future is here!

#drones

[John Muirhead-Gould @JonIsGold]

The airspeed of an unladen European swallow, a reasonable estimate is about 11 m/s, or roughly 24–25 mph / 39–40 km/h.

African swallows are less precisely defined because multiple species could qualify, but comparable species may cruise in a similar broad range, roughly 20–30 mph depending on species and conditions.

[John Muirhead-Gould @JonIsGold]

@OmicsOmicsBlog I mean food science is indeed primed (excuse the pun) for a revolution.... 🤔

[John Muirhead-Gould @JonIsGold]

The cheese snobbery is earned. But what they're actually describing is a 12-year coupled optimization - tune melt, break flavor; fix flavor, lose texture.

Thousands of iterations to hit three specs simultaneously on a living substrate.

Sound like any biochemical optimization problems you know? 😉

[John Muirhead-Gould @JonIsGold]

Wasn't planning to be at the Hilton Downtown Columbus today. Schedule opened up - the @OhioAG's 34th annual Two Days in May Conference on Victim Assistance is here. Grateful for @HIDGlobal's flexibility to show up where it matters. #TwoDaysInMay

[John Muirhead-Gould @JonIsGold]

Full source: https://t.co/YXClrIqJS9

Based on xai-org/x-algorithm (Apache 2.0, released May 15, 2026).

The predictor is a starting point — PRs welcome if you find better weight estimates from empirical testing.

What signal surprised you most?

[John Muirhead-Gould @JonIsGold]

xAI open-sourced their recommendation algorithm 3 days ago.

I read the Rust source code. Here's how your posts actually get ranked now — and a tool to predict your score.

🧵

[John Muirhead-Gould @JonIsGold]

What this means for your posts:

1. First line is everything — not_dwelled kills
2. Questions drive replies (high weight)
3. DM-worthy > likeable
4. Images boost dwell + photo_expand
5. Short promo posts score NEGATIVE
6. Data/numbers boost shares
7. Don't spam — diversity decay is exponential