Jordan Angle, PhD

Industry scientist in genomics & microbiology
Ph.D. - THE Ohio State University
he/him

[🍁KayElle N 95+ @KayElleTweets]

“It’s just allergies”
“Ive never had allergies before this!”
“New allergies”
“I keep breaking out in hives, I have no idea why!”
“I have asthma now 😓”
“Constant red bumps, not sure why” “my skin is so itchy”
“I can’t drink alcohol anymore….”

https://t.co/nInbm0RPpS

[Lindsay McAlpine MD @McAlpineLabYale]

Pleased to share our latest COVID Mind Study @ Yale publication: "Vascular inflammation in neuropsychiatric long COVID" Elevated markers of endothelial adhesion in LC correlates with lower verbal fluency and learning.
https://t.co/KeXUAnIhpD

[IntegralAnswers @IntegralAnswers]

1/ Long COVID is one of the most complex post-infectious syndromes ever studied.

A new review in Nature Communications Medicine attempts to unify the biology.

Here’s what’s established, what’s emerging, and what’s still speculative. 🧵

[Harry Spoelstra @HarrySpoelstra]

Genome-wide DNA methylation profiling in COVID-19 positive patients reveals alterations in pathways linked to neurological dysfunction

HOLY MACARONI!!

🚨FURTHER CONFIRMATION: SARS-CoV-2 doesn’t leave quietly, it permanently reprograms your genome toward Neurodegeneration!!!

➡️This new USA study performed whole-genome methylation sequencing (WGMS) on peripheral blood from 101 SARS-CoV-2-positive patients (asymptomatic to severe) versus 105 uninfected controls to map COVID-19-induced epigenetic changes and their links to neurological outcomes.

➡️Highlights:
• Widespread genome-wide DNA hypomethylation in infected individuals, markedly intensified in severe cases,

• Severity-stratified differentially methylated genes (DMGs): 19 in mild, 19 in moderate, and 35 in severe symptoms,

• DMGs overlapped both canonical immune-response pathways and genes tied to neurodegenerative diseases,

• Pathway enrichment (GSEA, g:Profiler, PANTHER, KEGG) strongly associated DMGs with Alzheimer’s disease, Parkinson’s disease, and neuropsychiatric conditions,

• Whole-genome methylation sequencing(WGMS) provided the first comprehensive severity-stratified map of these methylation shifts, implicating epigenetic reprogramming in acute immune dysregulation and potential long-term neurological sequelae, #Leonardi_effect

• “It is important to note that our study is not causative by nature and only indicates associations,"

• Study also supports the view that COVID-19 is a spectrum of distinct syndromes rather than a single disease entity.

‼️So, COVID-19 does not merely infect, it permanently rewires the human epigenome in patterns identical to Alzheimer’s and Parkinson’s, guaranteeing a future epidemic of neurological degeneration, 😧have a nice Saturday!
https://t.co/pXynKMAif3

[nature @Nature]

Imagine if a nasal spray could make you immune not only to the viruses that cause COVID-19 and influenza, but to all respiratory diseases

https://t.co/FwdOzf4WkS

[Jon Douglas @atranscendedman]

The NIH has this great project called LitCovid that gathers Long COVID research in one place.

It's kind of amazing to see the studies piling up and getting better.

Science takes its time, but it does show up.

https://t.co/l52R8VI1BM

[Jordan Angle, PhD @jordancangle]

@DrJ_surgeon @LeeKurtiss @michaelryan756 Then I would highly advise looking into the protections provided by the protein-based Novovax if that is a major concern for you given your unique health issues!

[Jordan Angle, PhD @jordancangle]

@LeeKurtiss @DrJ_surgeon @michaelryan756 No vaccines? None? That's.. practically Noone in the developed world.. 🤔

[Jordan Angle, PhD @jordancangle]

@Runningmansuzie @DrJ_surgeon @michaelryan756 To question is great! Science will always reveal the truth 💪 😎

[Jordan Angle, PhD @jordancangle]

@Runningmansuzie @DrJ_surgeon @michaelryan756 I am a scientist, wingnut lmao

[Jordan Angle, PhD @jordancangle]

@LeeKurtiss @DrJ_surgeon @michaelryan756 Great follow up for more clarity is here: https://t.co/gmQg7dpe5S

[Jordan Angle, PhD @jordancangle]

@Runningmansuzie @DrJ_surgeon @michaelryan756 Incorrect.

[Jordan Angle, PhD @jordancangle]

@LeeKurtiss @DrJ_surgeon @michaelryan756 Unfortunately covid itself causes it 8-10x the vaccine 🫠

[Jordan Angle, PhD @jordancangle]

@DrJ_surgeon @michaelryan756 Yes. This has been demonstrated to be false in the content of which you are using it.

[Jordan Angle, PhD @jordancangle]

@ckwrightphd @DeeWaynee94 No. Incorrect.

[Vipin M. Vashishtha @vipintukur]

New population-based data from Michigan shows that #LongCOVID is linked to persistent sleep problems—lasting up to 3 years after infection.

➡️ Compared with those without Long COVID, affected adults slept ~20 minutes less per night and were 2–3× more likely to sleep <6 hours, even years after infection. 1/

[Rolling Stone @RollingStone]

Long Covid Is Real — And It’s Changing an Entire Generation

Hundreds of thousands of kids in America are struggling with an illness that many doctors and schools refuse to recognize.e

Feature: https://t.co/q0QjHOh9Bq

[Douglas Yao @DouglasYaoDY]

CRISPR came from yogurt bacteria. GLP-1s came from Gila monster venom. Taq polymerase came from hot spring bacteria.

As much as we like to think that progress in biotech is driven by human design, our biggest breakthroughs over the years have all originated from nature.

[amykaufman @amykaufman84]

We have the choice to use the gift of our life to make the world a better place- or not to bother
- Jane Goodall
Thank you for bothering, Jane.

[The Spectator Index @spectatorindex]

BREAKING: Huntington's Disease, which is normally fatal within two decades, has been treated for the first time, according to researchers at the University College London and BBC report.