John Robb 🌁

Product leader @salesforce Former @tenyx_ai @dropbox @elastic @vmware - Hawk Hill, skiing, new music and bad Chicago sports teams

[John Robb 🌁 @jrobb]

November in San Francisco

[Mann Made Cinema @Hotshot_Movie]

This is a Pratt ad. CNN spent the entire primary shitting on the ONE candidate trying to fix all this, then…after they successfully merked him out of the general election, they run this searing indictment of the 2 candidates they just shilled for. 🤡 🤡

[Jason Cohen 🇺🇸 @JasonJournoDC]

💥NEW: @chamath on LA Mayor Election: “I’m for mathematical and statistical literacy. And what happened here is mathematically and statistically IMPOSSIBLE … I can tell you the statistical odds that this would have happened — and it’s one in a trillion!”

[Peter Rutzler @peterrutzler]

Gustavo Alfaro, the Paraguay coach, puts defeat down to the "complexity" of the US approach. "They dominated tactically, technically and physically... they create a pentagon in midfield... they have a solution to every problem".

[Jerry Thornton @jerrythornton]

I had to watch this five times to be sure it’s not AI. Nope. It’s real. Just one of Boston’s Finest being ambassador to the world.

[USMNT Only @usmntonly]

JUST A REMINDER.

Paraguay beat Brazil and Argentina and had the best defensive record in South American World Cup qualifying.

They just lost 4-1 to the USMNT in their opening match at the 2026 World Cup final.

[USMNT Only @usmntonly]

The USMNT scored as many goals in the first half of their 2026 World Cup opening match against Paraguay (3) as they did in the ENTIRE 2022 World Cup campaign (3).

What a start 🇺🇸👏🔥

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. I've held dying hearts in my hands in the cath lab at 3 AM. And I need to tell you something that changes everything about how we prevent heart attacks.

For decades, the entire field was built on one target: lower LDL cholesterol. Statins save lives — that's settled science. But too many of my patients did everything right — took their statins, hit their numbers, lived clean — and still ended up on my table with a ruptured artery.

We were treating the smoke while the fire kept burning.
The fire is inflammation. And the evidence is now overwhelming.

The CANTOS trial proved it first — lowering inflammation independent of cholesterol reduced cardiac events. But the newer data is what keeps me up at night.

AI-enhanced CT angiography can now detect inflamed arteries by measuring changes in the fat surrounding your coronary vessels — the perivascular fat attenuation index. Higher inflammation in the fat around even one artery independently predicts cardiac death. When multiple arteries show inflammation, the risk multiplies dramatically — even in patients whose cholesterol looks perfect.

This isn't theoretical. This is measurable. Right now. On a scan you can get this month.

Low-dose colchicine — a drug that's been around for centuries for gout — is now FDA-approved specifically for reducing cardiovascular events. It works by quieting the inflammatory cascade that destabilizes the plaque sitting in your arteries. A pill that costs pennies is saving lives the statins couldn't reach.

And the next wave is already in Phase 3 trials. Ziltivekimab — an IL-6 inhibitor — targets the central inflammatory pathway driving atherosclerosis. Phase 2 data showed a 90% reduction in hsCRP. The ZEUS cardiovascular outcomes trial is enrolling now, with results expected late 2026 into 2027. If positive, anti-inflammatory therapy will become standard in managing heart disease alongside lipid-lowering. The era of inflammation-targeted cardiology is arriving.
But it goes deeper than drugs. AI is now predicting heart failure and cardiac events 5+ years before symptoms — integrating CT imaging, electronic health records, and genetic data with accuracy that jumps far beyond traditional risk calculators.

And polygenic risk scores — a simple genetic test that flags inherited cardiovascular risk — are now formally recognized as a risk-enhancing factor in the 2026 ACC/AHA guidelines. A single blood draw can reveal risk that's been silently building since birth. Decades before the first chest pain.

Here's what this means for you right now — today:
Ask your doctor for a high-sensitivity CRP test. It's cheap, routine, and measures the systemic inflammation that standard cholesterol panels completely miss. You can have perfect LDL and inflamed arteries that are quietly preparing to rupture.
If your hsCRP is elevated, discuss low-dose colchicine with your physician. It's FDA-approved for exactly this.
Push for a coronary CT angiography with AI plaque and inflammation analysis if you have risk factors. This isn't the stress test your parents got. This is 3D visualization of your actual arteries — with AI quantifying not just how much plaque you have, but what kind it is and whether the surrounding tissue is inflamed.
Consider polygenic risk score testing — especially with a family history of early heart disease. It's now guideline-supported.

And the foundation that never changes: move daily, eat real food, sleep 7-9 hours, manage stress, and know your numbers — ApoB, Lp(a), hsCRP, fasting insulin.
I left Iran as a child with nothing. I rebuilt everything in a country that gave me the freedom to become a physician. I've spent twenty years watching patients get second chances.

The ones who haunt me aren't the ones who died on my table. They're the ones who survived but never acted on what the science was telling them — years before the event that didn't have to happen.

You can have perfect cholesterol and still have a heart attack. Inflammation plus genetics can drive plaque rupture in arteries that look "fine" on a standard panel.
The myth that normal cholesterol means you're safe has cost more lives than I can count.

We now have the tools to detect the fire — not just the smoke. AI to see it. Genetics to predict it. Drugs to quiet it. And the ancient basics — movement, real food, sleep, purpose — to prevent it from starting.

Prevention is the new cure. And the science to make it real is no longer coming.
It's here.

[John Robb 🌁 @jrobb]

https://t.co/TnIm6q4WM0

[Rod Wong, MD @docrodwong]

a standing ovation for daraxonrasib at asco. over 40k oncologists, entrepreneurs, investors, and patient advocates together celebrating revmed's breakthru in the fight against pancreatic cancer. u never forget these moments. it's what innovation is all about.

[John Robb 🌁 @jrobb]

I am proud to get up every day and know I am part of this tech community

[Derek Thompson @DKThomp]

This has quietly been a miracle month in medicine.

In the last 5 weeks we’ve got news on:

- retatrutide, the triple agonist GLP-1 from Lilly, basically melting fat and body-wide inflammation at record levels
- RevMed’s new pancreatic cancer drug showing unprecedented abilities to extend life
- small trial of a one-and-done PCSK9 gene editing therapy for slashing LDL cholesterol
- Mayo’s AI-assisted radiology showing vastly improved cancer detection
- this new therapy for metastatic solid tumors

This stuff is at varying levels of evidence. Retatrutide is ~100% on its way, other stuff needs more clinical trial data. But put it together and we’re maybe on the verge of majorly reducing the mortality of heart disease and cancer, the two leading causes of death in America.

[Derek Thompson @DKThomp]

This has quietly been a miracle month in medicine.

In the last 5 weeks we’ve got news on:

- retatrutide, the triple agonist GLP-1 from Lilly, basically melting fat and body-wide inflammation at record levels
- RevMed’s new pancreatic cancer drug showing unprecedented abilities to extend life
- small trial of a one-and-done PCSK9 gene editing therapy for slashing LDL cholesterol
- Mayo’s AI-assisted radiology showing vastly improved cancer detection
- this new therapy for metastatic solid tumors

This stuff is at varying levels of evidence. Retatrutide is ~100% on its way, other stuff needs more clinical trial data. But put it together and we’re maybe on the verge of majorly reducing the mortality of heart disease and cancer, the two leading causes of death in America.

[Visegrád 24 @visegrad24]

50 000 Poles showed up at the main square in Kraków’s Old Town last week to celebrate the promotion of their team Wisla Krakow to the first league.

They cleaned up the square before going home, leaving no garbage behind.

0 arrests, 0 violence, 0 looting

[NUCLR GOLF @NUCLRGOLF]

🚨🗣️🤖 #NEW — Bryson DeChambeau says he turned to Google’s Gemini (AI) to try and help fix his swing after the 3rd round. He fired a 5-under (65) on Sunday in Korea on route to a team victory for his Crushers GC.

“I was slamming the club in the ground trying to figure out what to do. I was frustrated. Been trying everything in my body. I didn't actually figure it out on the range…”

“I went back and started talking to Gemini and trying to figure out just what it could be to passively make the club turn over. Hands just felt like they were moving forward like this and I couldn't get the club to turn over. Even if I tried to stop it here, it still wouldn't turn over.”

Thoughts on Bryson’s game? @BrysonLegion

[Crémieux @cremieuxrecueil]

Eli Lilly has done it.

They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol.

That means they'll be able to effectively prevent most heart disease with a single infusion!

[David Sacks @DavidSacks]

Q: How are job postings for software engineers rising rapidly despite AI agents automating coding?

A: Because there’s far more code to manage than ever before. We’re already seeing a 14x YoY increase in GitHub commits, and it’s accelerating.

AI has dramatically lowered the cost of writing code, so it’s now being used across far more businesses, applications, and use cases.

We’re at the beginning of a massive productivity boom driven by the proliferation of bespoke software throughout the entire economy.

Coding has been AI’s breakout use case this year. The fact that it’s increased demand for software engineers — rather than decreased it — should call into question the entire “AI will cause mass job loss” narrative.

[Chris Casquejo @ChrisCasquejo]

Rebuild Martin Stadium out of brick and steel and make it permanent.
Rename it Kelly Amonte Hiller Stadium.

[West Lot Pirates @westlotpirates]

Honestly: it felt like more.

There wasn't any kind of "wine & cheese crowd clear-out" in the South Endzone at halftime. This place was packed, in EVERY section, from start to finish💯

[Daily NU Sports @DailyNU_Sports]

Northwestern defeated North Carolina 14-11 to regain its first NCAA National Championship since 2023. Freshman attacker Gabriella McCollester led the Wildcats’ scoring, with a career-high four goals.
—
Reported by @charlie_perlman and @IsaiahStei27

https://t.co/fFSSVNZLKD

[Northwestern Lacrosse @NULax]

NATIONAL CHAMPIONS! 🏆 #CATSWIN

[Nick shirley @nickshirleyy]

🚨The Minnesota fraud empire is falling:
Yesterday 15 fraudsters were charged and $90 million was busted. The MSM tried to cover for the fraudsters. @GovTimWalz called it "white supremacy" to expose it and @IlhanMN is completely SILENT.

Independent journalism defeated an entire fraud network upheld by billions of dollars with support from corrupt politicians who allowed this fraud and the MSM who failed to report it.

Major win for America and hardworking law-abiding taxpaying citizens. This is just the beginning.
Arrest them all.