JulienKlimmt

Postdoc @PaquetLab using stem cells and genome editing to model Alzheimer's disease @ISD_research, LMU Munich, Germany

[JulienKlimmt @JulienKlimmt]

Big congratulations @janinakupke and thanks a lot for never giving up on the story, it turned out really great! 😊

[Janina Kupke @janinakupke]

Out in @npp_journal:
Dnmt3a1 regulates hippocampus-dependent memory via the downstream target Nrp1

Distinct Dnmt3a isoforms regulate memory through a unique transcriptional program.

Thanks to all the authors (@JulienKlimmt...&institutions @zi_mannheim)
https://t.co/rzniXQikQc

[Dominik Paquet @PaquetLab]

We have an open PhD position about generating a human #iPSC derived brain tissue model of Frontotemporal dementia #FTD with GRN mutations, fully funded by @alzassociation, in close collaboration with @Haass_Lab . Please apply via email and join us! Please RT - thanks!

[JulienKlimmt @JulienKlimmt]

Thank you very much @ISMND1 for giving me the opportunity to present our work done @PaquetLab! Great conference with great discussions!

[International Society for Molecular Neurodegen. @ISMND1]

Next up, @JulienKlimmt @LMU_Muenchen highlights their work on reproducible and controllable human #iPSC-derived cortical tissue models

#ISMNDNextGen

[JulienKlimmt @JulienKlimmt]

@IgorKhalins @BbCaen @ISD_Research Congratulations Igor, great to hear! 😊

[JulienKlimmt @JulienKlimmt]

@janinakupke Thank you @janinakupke and all co-authors for making this such a great story, I'm very excited to see it 😊

[Janina Kupke @janinakupke]

🚨🚨🚨 The first part of my PhD thesis 🎓 is now available as preprint!
If you want to know more about DNA methyltransferases in memory formation then check it out and read the thread below 🧵1/5
⬇️⬇️⬇️ #epigenetic #memory

[JulienKlimmt @JulienKlimmt]

Very excited and happy to see our cortical neuron differentiation protocol published! 🥳 We get highly pure and functional cultures that are stable long-term with minimal contamination by other cell types! Check out the thread below for more info ⬇️

[Dominik Paquet @PaquetLab]

Out @STARProtocols: our optimized protocol to reliably and reproducibly differentiate cortical neurons from human #iPSCs, developed @ISD_Research @LMU_Uniklinikum @LMU_Muenchen. Our highly pure neuron cultures are stable for over 1 year! https://t.co/4d3kfq0g06) Thread👇1/9

[JulienKlimmt @JulienKlimmt]

@SimonTSchafer @CellCellPress @CellPressNews @TU_Muenchen @salkinstitute Congrats Simon, great work! 😃

[JulienKlimmt @JulienKlimmt]

@evanhstanton @BaCell3D @PaquetLab @ISSCR Thanks Evan, I'll have a look!

[JulienKlimmt @JulienKlimmt]

I had a great time @BaCell3D presenting our work @PaquetLab, listening to great science, and meeting great people! Looking forward to coming back next year! 😊

[BaCell3D @BaCell3D]

Julian Klimmt from the @LMU_Muenchen presents iPSC derived cortical #organoid model for advancing research on Alzheimer’s disease

[Dominik Paquet @PaquetLab]

Want to hear more about our #iPSC based brain tissue models for #Alzheimer and #FTD just presented at #ADPD2021 ? Join us at posters 84 by @JulienKlimmt, 267 by @AngelikaDannert or 393 by @soph_robinson1 after the session or during lunch break today @adpdnet !

[Dominik Paquet @PaquetLab]

We are excited to be at #ADPD2022 in #Barcelona to present our work on #iPSC models of #neurodegeneration. Please see @AngelikaDannert at poster 267, @JulienKlimmt at poster 84, @soph_robinson1 at poster 393, or my talk on Thu 10.25am Room 113! @adpdnet @Haass_Lab

[JulienKlimmt @JulienKlimmt]

@EinarKrogsaeter @lysolabmunich @PaquetLab @lifescimunich @nclStiftung Congratulations Einar! 😀 well deserved! 🥳

[JulienKlimmt @JulienKlimmt]

Happy to present our work at #ADPD2021, poster P133! Email or DM me with any questions or to discuss!

[Dominik Paquet @PaquetLab]

Very happy to be at the virtual @adpdnet #ADPD2021! @JulienKlimmt and @AngelikaDannert from the lab are presenting posters describing our work on #CRISPR edited #iPSC based brain tissue models of #Alzheimer’s disease and #Tauopathies. Check them out if you are attending!

[Dominik Paquet @PaquetLab]

New @NatureProtocols from our lab @ISD_Research @LMU_Uniklinikum @LMU_Muenchen: https://t.co/OxxiHzeQSM. We recently described deleterious on-target effects after CRISPR editing in up to 40% of human #iPSCs and now present a simple and broadly applicable protocol for detection 👇

[JulienKlimmt @JulienKlimmt]

@davidvcbrito @FENSorg @SPNeurociencias @UniHeidelberg @IMMolecular @ChampalimaudF Great lab and great PI, can just recommend it!

[David Brito @davidvcbrito]

Please RT: Great opportunity-PhD Student position at the Heidelberg University, Germany in the field of Learning and Memory. @FENSorg @SPNeurociencias @UniHeidelberg @IMMolecular @ChampalimaudF

[Kübra Gülmez Karaca @kubikubicv]

Our new paper in #Neurobiology of #Aging shows that human aging is associated with increased #Gadd45g expression in the #hippocampus and modeling this in #mice leads to #memory impairments. Curious? Check:
https://t.co/JmCjpUtQBb

👏 @davidvcbrito @janinakupke @ELSneuroscience

[David Brito @davidvcbrito]

Our recent work on gene expression during human #aging and #cogitive decline is now available. Thanks to everyone involved especially to Ana Oliveira, @kubikubicv, @janinakupke and great collaboration with @luisavlopes
Read it here: https://t.co/oa2B7HX29r

[Dominik Paquet @PaquetLab]

Out today @CellReports : first #CRISPR paper from our lab @isd_research @LMU_Uniklinikum @LMU_Muenchen. We reveal frequent and deleterious on-target effects after CRISPR editing in human #iPSCs and describe broadly applicable detection methods. https://t.co/XIE9bJaoVt Thread 👇