MD. Clinical Geneticist. MSc Precision Cancer Medicine | Clinical Bioinfomatics (on the way) Precision and Personalized Medicine | Research & Innovation
Artificial intelligence-assisted statistical analysis and statistical review: evidence (2023-2025) and implications for internal medicine
https://t.co/DlbliUbz5L
Systematic review asks: What works?
Scoping review asks: What exists?
Many researchers confuse the two!
---------------------------------------
Learn in more detail in this accredited course:
🔗 https://t.co/6FSSgwm0M3
----------------------------------------
Here's when a scoping review makes sense:
— You're exploring an emerging area
— You want to identify what research methods people are using
— You need to clarify how a concept is being defined
— You want to spot where the research gaps are
Stick with systematic reviews when:
— You have a focused question
— You need to inform policy or practice decisions
— You want to compare interventions
— Critical appraisal matters for your question
---
1/6
Does extreme age inherently mean poor health?
New researchanalyzed the biological profile of a supercentenarian and found a fascinating paradox: canonical markers of #aging (like telomere attrition) coexisted with powerful protective mechanisms. This suggests #longevity isn't about escaping aging, but about maintaining remarkable resilience against age-associated diseases.
The pillars of this resilience include:
🧬 Protective genetics: advantageous alleles for #cardiovascular/brain health and a notable absence of damaging mutations.
🔬 Efficient #metabolism and low inflammation: favorable lipidomic profile and low #inflammation markers (like IL-6).
🥛 Rejuvenated gut #microbiome: linked to dietary habits like yogurt intake, potentially supported by probiotics (e.g., Bifidobacterium).
🥑 Favorable lifestyle synergy: echoing lessons from Blue Zones (Okinawa, Sardinia, etc.): plant-based diets, integrated #physicalactivity, and strong social bonds.
This study moves ubeyond the quest to simply "slow aging." It frames exceptional longevity as the coexistence of senescence and sustained functional safeguards - a balance of resilience, plasticity, and preserved molecular integrity.
https://t.co/aMPKdVWtaL
🚨BREAKING: Google just dropped another hit!
It's called PaperBanana and it generates publication-ready academic illustrations from just your methodology text.
No Figma. No manual design. No illustration skills needed.
Here's how it works:
A team of AI agents runs behind the scenes
→ One finds good diagram examples
→ One plans the structure
→ One styles the layout
→ One generates the image
→ One critiques and improves it
Here's the wildest part:
Random reference examples work nearly as well as perfectly matched ones. What matters is showing the model what good diagrams look like, not finding the topically perfect reference.
In blind evaluations, humans preferred PaperBanana outputs 75% of the time.
This is the recursion we've been waiting for AI systems that can fully document themselves visually.
Waitlist’s open, Link in the first comment.
Reporting of molecular test results from cell-free DNA analyses: expert consensus recommendations from the 2023 European Liquid Biopsy Society ctDNA Workshop - eBioMedicine https://t.co/3wpUQIBZfz
No other class of anticancer drug comes close to the number of cures that can be attributed to chemotherapy.
Yet, our understanding of how it truly works is extremely limited.
This perspective on the topic is a must read.
Including for ADC enthusiasts.
https://t.co/WJ99Er8aV9
Disrupted sleep and circadian rhythms are deeply intertwined with mental health.
They don’t just reflect mental illness—they can drive it. And psychiatric symptoms further disrupt sleep.
Restoring circadian health could be a powerful treatment 🧵 1/12
The Rare Therapies Launchpad: a pilot program for individualized medicines in the UK. Correspondence from Daniel O’Connor, Julia Vitarello and colleagues
@GenomicsEngland@UniofOxford@BostonChildrens Mila’s Miracle Foundation
https://t.co/rApT4ctgvh