Mitos, plastids, endosymbiosis, gene transfer, origins of life, tRNAs and all things wonky in mol. evolution 🧬 Postdoc in McCutcheon lab. HG fellow @HHMINEWS
Treasure your exceptions, but also your contaminants? The sequencing of “resident” spider mites confirms bizarre mitochondrial tRNA structure (some armless!) but also the novel discovery of transcription of tRNA genes in both directions~Mirrored tRNAs 🧬🪞 https://t.co/P4jEv7Sm9R
@staal1978 @SynBio1 Certainly fun to think about ☺️ lots of opportunity for exciting discussions online. Also important to have a critical perspective from people in the field 💚
Check out our new preprint on plant🌱mitoribosome! We captured it in action, translating mRNA, and combining cryo-EM and Nanopore sequencing, identified key rRNA modifications. Plus we delve into a late-stage maturation step of the small subunit.
📖:https://t.co/1a1Zjb28SW
Collaborative work of @slavicaPD, @Hashemyaser4, Jovanovic Lab and @DjuranovicLab - a new method to isolate ribosomes and translational material in minutes. We show multiple usage of our RAPPL method in biochemical and structural assays with ribosomes. Please be free to contact us for further instructions if needed. @IsraelF96135088 you'll like this one.
A rapid, facile, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies https://t.co/qqJA6y2ysU
A new fascinating symbiosis in plankton unveiled by imaging and physiology: Hijacking and Integration of Algal Plastids and Mitochondria in a Polar Planktonic Host. New preprint of the team led by @Kedige98 with @dudin_o@e_hehenberger@florianjug groups
https://t.co/HBccgmexGO
Check out our paper! We identify a population of retinal progenitors that are maintained late in human retinal development, and give rise to both first- and last-born cell types in the retina, condensing 100 days of retinal development into a small region at the retinal margin!
Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳
Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!
https://t.co/cxHl1j20CJ
@DNAprymer@SloanEvoLab@ThePlantCell Nothing to do with being PC. Like the instruction states, a trait can be ancestral, not an extant species. People are describing “directionally” on a tree that doesn’t exist.
Excited to see our work out in preprint form! Not all mitochondria carry mtDNA in plants- so we asked: is there a link between dynamics, intermitochondrial connectivity and presence/absence of DNA- and we show- yes! 🤓🌱
4) The scientific method also applies to computational results: proper controls and negating all alternative hypotheses are just as important in computational biology as in bench experiments.
My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses.
(👇 I recommend sound ON for the video 🎹)
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The mitochondrial protein synthesis machinery in 4D (gorgeous 3D structure plus motion over time)
This is how mitochondria synthesize parts of the life-giving electron transport chain
The Hagler lab is hiring a research technician/assistant!!! Please consider applying if you are interested in RNA structure, RNA-protein interactions, and drug discovery. https://t.co/58BR0GiIrV