Junayd

Ecom Founder. Gooner. New Yorker. Berliner. Fintech bro. Ex Dem Pol. Likes ≠ Endorsements.

[Junayd @JunaydFM]

Research like this gets me so excited for the future. Longevity and human health will accelerate massively in the coming years. Great time to be a biotech investor/early-adopter. https://t.co/zALlxkP4uU

[Avi Roy @agingroy]

If you sleep 8 hours a night, you'll spend roughly 26 years of your life asleep. People with rare short-sleeper mutations (DEC2, ADRB1) need only 4-6 hours, with no health penalty. They get back 7-13 years of waking life.

The molecule that controls this is orexin. Your brain's wakefulness switch. Block it, you sleep better (3 drugs already do this). Activate it, you need less sleep. Pharma is racing to build that activator: @EliLillyandCo paid $6.3B, @TakedaPharma expects @US_FDA approval this year.

Now @paulkhls and @BioProtocol designed a selective orexin activator using AI in 24 hours, for $500 in lab costs. Instead of targeting narcolepsy like everyone else, they're going after ADHD. Nobody in the pipeline is doing that.

Early stage, real obstacles (peptide half-life, brain delivery), but the speed of this is remarkable.

@paulkhls curious about your delivery strategy for getting a peptide past the blood-brain barrier?