k64m

[k64m @k64m1]

@MichaelSandstro @amcalber Late, but - in the final version of that paper (https://t.co/r0t8pEiABP) the discussion notes why that probably wouldn't work.

Key here is that when IL-4/TNF are blocked from the start, IgG4 skewing doesn't develop, so it seems those are necessary for IgG4 class switching.

[k64m @k64m1]

@m_a_n_u______ @Jikkyleaks @shezbanga @paul_wilson_nz @FnqSilver @Topaz20211 @PeterHotez I made this to check out the attention a colleague's paper was getting. Was surprised to see the authors praised for digging into the IgG4 trend but called pharma shills at the same time, for supposedly promoting the drugs studied in the paper as a general fix (they did not).

[k64m @k64m1]

@paul_wilson_nz @FnqSilver @DrSusanOliver1 @VaccineMole @Johnincarlisle @Jikkyleaks There's certainly something very odd about grabbing onto a paper's one finding corroborating the IgG4 trend, but discrediting the authors as pharma shills in the same breath. It's one article, do you trust it or not?

[k64m @k64m1]

@paul_wilson_nz @FnqSilver @DrSusanOliver1 @VaccineMole @Johnincarlisle @Jikkyleaks Oh, all I got was a quiet block.
:(

[k64m @k64m1]

@paul_wilson_nz @FnqSilver @DrSusanOliver1 @VaccineMole @Johnincarlisle @Jikkyleaks It's unfortunate seeing clown emojis thrown around over something the article doesn't actually say, but ultimately these people aren't the target audience. If the paper gets reviewed and properly published, and does its part towards better understanding, it's all fine by us.

[k64m @k64m1]

@paul_wilson_nz @FnqSilver @DrSusanOliver1 @VaccineMole @Johnincarlisle @Jikkyleaks Oh, that's fair. One of my colleagues helped write that paper, and they were very excited to see it get a lot of attention right off the bat. Wanted to look for myself, but it's disheartening seeing people misrepresent it like this. It just doesn't say these things they claim.

[k64m @k64m1]

@paul_wilson_nz @FnqSilver @DrSusanOliver1 @VaccineMole @Johnincarlisle @Jikkyleaks Maybe there's a little bit of Xeno in all of us.

Also, I'm flattered for the follow but I meant not intending to stick around. I made this account off of a 10 minute mail address; the second I log off, it'll be lost to the ether. Really not a fan of twitter.

[k64m @k64m1]

@paul_wilson_nz @FnqSilver @DrSusanOliver1 @VaccineMole @Johnincarlisle @Jikkyleaks Good morning, and good evening from western Europe :)

[k64m @k64m1]

@FnqSilver @paul_wilson_nz @DrSusanOliver1 @VaccineMole @Johnincarlisle @Jikkyleaks Gotta scroll further down.

Good luck with the things!

[k64m @k64m1]

@FnqSilver @paul_wilson_nz @DrSusanOliver1 @VaccineMole @Johnincarlisle @Jikkyleaks Go for it. It wasn't my first reply on this account; I did that yesterday.
Either way, I'm just going to give up now. You insist that paper says something, but you won't say where no matter what. @paul_wilson_nz congrats on getting to live in this person's head rent free though.

[k64m @k64m1]

@FnqSilver @paul_wilson_nz @DrSusanOliver1 @VaccineMole @Johnincarlisle @Jikkyleaks 5 seconds to google, and "_nz" in his username + the flag in his display, respectively.

Fourth time asking for a straight answer -- where does it say to start prescribing these drugs to people just to prevent IgG4 induction?

[k64m @k64m1]

@FnqSilver @paul_wilson_nz @DrSusanOliver1 @VaccineMole @Johnincarlisle @Jikkyleaks Yesterday, actually. But also, the guy's NZ. It's 7am there now. He stopped replying 5h ago. You can put the pieces together here, right?
Still waiting to hear where the article says to start giving people these drugs, by the way.

[k64m @k64m1]

@FnqSilver @paul_wilson_nz @DrSusanOliver1 @VaccineMole @Johnincarlisle @Jikkyleaks Your back and forth with him was at the top of the medrxiv page for a while. But again: where does this paper say they recommend these drugs as fixes to IgG4 induction? If it were such a key conclusion, it should be clearly written in the abstract, introduction and discussion.

[k64m @k64m1]

@FnqSilver @Fishyfish666 @kpvsmom @CommunityNotes Autoimmune patients take drugs that blocks specific signals. They get more or less equal total IgG but less % IgG4. Useful hints about what these signals do for IgG4 switching in general.
That's the message of this paper. What are you trying to say with a screenshot of its title?

[k64m @k64m1]

@FnqSilver @paul_wilson_nz @DrSusanOliver1 @VaccineMole @Johnincarlisle @Jikkyleaks Not every new account is a sockpuppet, but I'm sure the other guy is flattered. I just made a throwaway because I don't intend to spend much time on this awful site.
Either way, if you've read it, please point out where they suggest these drugs as "solutions" to IgG4 switching.

[k64m @k64m1]

@Fishyfish666 @kpvsmom @CommunityNotes The article isn't suggesting to use immunosuppressants like that, at all. They only tested people already using them to learn more about exactly what drives IgG4 switch.
Besides, high affinity IgG4 still neutralizes like any other subclass, and more inflammation =/= better.

[k64m @k64m1]

@FnqSilver @paul_wilson_nz @DrSusanOliver1 @VaccineMole @Johnincarlisle @Jikkyleaks This paper is not studying or suggesting immunosuppressants as ways to stop IgG4 induction. They tested people already using those drugs to learn more about what makes IgG4 switching happen in general; useful fundamental knowledge.

[k64m @k64m1]

@chances4u @Jikkyleaks If that sounds weird, it's because it's a misrepresentation. The article doesn't suggest these drugs as ways to fix IgG4. They only tested people already taking them for autoimmune diseases, to see how it affects IgG4 switch and learn more about what makes it happen in general.

[k64m @k64m1]

@MikeDonio @Jikkyleaks Have you read the paper? That isn't what the authors are suggesting at all. They only looked to what degree IgG4 switch happened in people *already* taking these drugs, for actual autoimmune diseases, to learn more about what factors drive IgG4 switch in general.

[k64m @k64m1]

@balls_pepper @exponengrowth @medrxivpreprint @Covid19Critical IgG4 isn't really a clear-cut problem. It drives less inflammation, but inflammation is not strictly good. The authors also note this; people ending up in ICU with severe disease, especially young/healthy, usually suffer *too much* inflammation. Cytokine storm etc.