Kaijun Jiang

[Kaijun Jiang @kaijun_jiang]

We would love to use AI to design vaccine or therapeutic antibodies. Maybe it’s more practical until the AI could predict the viral evolution precisely. Then we also need to consider the selective pressure on the evolution from these relatively conservative antibodies.

[Kaijun Jiang @kaijun_jiang]

@Minderpal3 @lufthansa @Lufthansa_USA Hope your wife and you still have the job.

[Kaijun Jiang @kaijun_jiang]

Twice a day on NHP, but maybe around 4 times a day in humans. In terms of the paper, better to modify the antibody to increase the half life. Also, we would see the 9114 escape mutants, if this was approved.

[SARS‑CoV‑2 (COVID-19) @COVID19_disease]

https://t.co/Ld578NdCC5

[Kaijun Jiang @kaijun_jiang]

The trouble shooting comes from my gut feeling.

[Kaijun Jiang @kaijun_jiang]

Great and efficient team work. Meet our amazing collaborators from Rockefeller University!

[Casanova Lab @casanova_lab]

1/ A year ago, a 71-year-old Louisiana man died from H5N1, marking the first avian flu death in the US. Now we report in @JExpMed that the cause of his death is rogue autoantibodies neutralizing type I IFN (AutoAb-IFN). https://t.co/L3COz2taJR

[Kaijun Jiang @kaijun_jiang]

@CDCFlu @florian_krammer No pig kissing

[Kaijun Jiang @kaijun_jiang]

@PicturesFoIder You need a wiper

[Kaijun Jiang @kaijun_jiang]

US reports first outbreak of deadly H7N9 bird flu since 2017 | Reuters https://t.co/1jX1rqrZLw

[Kaijun Jiang @kaijun_jiang]

@DrEricDing Could be wild bird

[Kaijun Jiang @kaijun_jiang]

Hopefully, the vaccine is good enough to eliminate the virus. Otherwise, it will circulate and keep evolving. https://t.co/uwQuud1VM7

[Kaijun Jiang @kaijun_jiang]

After drying with low temperature, the orange peel can be made as snack and medicine.

[Nature is Amazing ☘️ @AMAZlNGNATURE]

They clearly know something we don't

[Kaijun Jiang @kaijun_jiang]

A woman was discharged after two months hospitalization. She was infected by H10N3, the fourth case globally. She was in ICU and received ECMO. Had contact with chickens and birds in market.

[Kaijun Jiang @kaijun_jiang]

@DrEricDing What you are seeing in the ER in China happens every year even before the pandemic. Please check the genotype of the H5N1s in U.S., some segments traces back to the influenza viruses from Europe. One epidemiology paper might be online to tell where the H5N1s in U.S. come from.

[Kaijun Jiang @kaijun_jiang]

Is it possible to stop sharing milk equipments? It’s good to take the regulation in the poultry farms.

[Kaijun Jiang @kaijun_jiang]

Try to avoid hunting in the wild during the winter at least this winter season

[CDC @CDCgov]

CDC confirms first severe case of H5N1 Bird Flu in the U.S. While an investigation into the source of the infection is ongoing, it has been determined that the patient had exposure to sick and dead birds in backyard flocks.

No person-to-person spread of H5 bird flu has been detected. This case does not change CDC’s overall assessment of the immediate risk to the public’s health from H5N1 bird flu, which remains low.

Read full statement: https://t.co/a3XJb9zc31

[Kaijun Jiang @kaijun_jiang]

@HNimanFC Yes, I did that, which exactly shows the mixture. Just wonder if any other resources mentioned this so far.
Also, thanks for tracking the H5N1. I’m a PhD student in Mount Sinai, working on H5N1. Your work is a huge help.

[Kaijun Jiang @kaijun_jiang]

Are we?
1. We have 2,3 sialic acid in the lower respiratory, which H5N1 binds
2. This is the HA protein level, not the virus.
3. The virus has 8 segments. Receptor binding preference is important. However, for disease spreading, the virus needs to replicate efficiently.

[Danielle Beckman @DaniBeckman]

Paper just out in Science. We are one mutation away from Human-to-Human transmission of #H5N1 #BirdFlu
We are so screwed...
https://t.co/KkPGj3dSQl

[Kaijun Jiang @kaijun_jiang]

I need my mind back.