What's a pseudoligase?🧐
Well, it looks a lot like an #ubiquitin E3 ligase but (on its own) can't catalyse ubiquitination. In our new ✨preprint✨ we see 12% of TRIM protein RING domains are actually pseudoligases! Implications in #immunity#cancer#neurodegeneration#TPD +more!
Check out this awesome paper from my colleagues in @KatrinRittinger lab at @TheCrick, uncovering the functions and mechanisms of two very interesting TRIM proteins! Amazing work @ddeos 🔬🎉
@katmcphie and I wrote a review to answer all your burning questions about fragment based drug discovery in the ubiquitin system! @KatrinRittinger https://t.co/i23RW7OPu5
Check out the review that @cassandrak94 and I wrote, where we've discussed the current state of fragment-based drug discovery targeting the ubiquitin system! We're very excited to see it published 🎉 👩🔬
@KatrinRittinger@TheCrick
https://t.co/Fscw93IkLh
Was an absolute pleasure to present a poster on some of my PhD research at RSC Chemical Biology Meets Drug Discovery 2022 @TheCrick! Thanks to @RSC_CBBG for the opportunity and for organising such a great event!