Sunada Khadka

MD Anderson Cancer Center
Scientist @ Loxo@Lilly

[Sunada Khadka @KhadkaSunada]

Annapurna Base Camp (4130 m)!! #ABCtrek #Nepal

[Sunada Khadka @KhadkaSunada]

@PatrickHwuMD @deb_silverman @MDAndersonNews Rest in peace, Deb 🕊

Deb truly inspired so many of us at
@MDA_UTHGrad GSBS and beyond! Indeed a huge loss.

[Nepal Mission to the UN @NepalUNNY]

🇳🇵#Nepal’s position on Ukraine is clear.

Principles of #sovereignty, territorial integrity, political independence & non-aggression as enshrined in the #UN Charter are inviolable, said @amritrai555 in explanation of vote at 11th Emergency Special Session today.
@MofaNepal

[Sunada Khadka @KhadkaSunada]

Great work, Yohei, @YYoshihama! Congratulations!

[Muller Lab @Muller_Lab]

https://t.co/7pKg9wVI8x

A high-quality collateral-lethality drug target validation study and description of a novel PTDSS1 inhibitor by Scientists from @DaiichiSankyoJP

1) Validation of response in isogenic null/WT human cancer cells in culture/CDX

2) Mouse syngeneic

[Muller Lab @Muller_Lab]

@KhadkaSunada @mzspectrum Underlying assumption is that toxins and selection markers used to maintain genetic alterations (shRNA) are neutral with respects to the experimental effects under study, but this is a nice example where this is not the case.

Probably happens more often than Biologists realize

[Sunada Khadka @KhadkaSunada]

@Muller_Lab @RonDePinho

[Sunada Khadka @KhadkaSunada]

If puromycin is your favorite selection antibiotic, this may be relevant!
Genetic depletion of de novo coenzyme A biosynthesis exacerbates puromycin toxicity

A fun collaboration with @mzspectrum and team!

https://t.co/CdKNN4jg7H

[Sunada Khadka @KhadkaSunada]

This is a preliminary report, but puromycin remains a staple selection antibiotic, and our findings warrant caution in the use of puromycin, especially in studies that impinge on CoA/acylCoA metabolism.

[Sunada Khadka @KhadkaSunada]

Congrats Sam, Christian and the team!
@SamBarrittYes @DibbleLab

[Sam Barritt @SamBarrittYes]

My PhD work in @DibbleLab and @alex_toker lab on Coenzyme A metabolism and PI3K signaling is published! Honored to be a part of this team and I've learned so much. Full tweetorial from Christian to come, so I'll do a fun one. Welcome to CoAchella 🧵1/8: https://t.co/DYONKV4mca

[Sunada Khadka @KhadkaSunada]

@FBetull You got this, friend. Rooting for you.

[Sunada Khadka @KhadkaSunada]

@AlexisSMobley Thank you, Alexis!! Can’t believe we all started together 6 years ago, and here we are. Congrats to all of us.

[Sunada Khadka @KhadkaSunada]

Eternally grateful!! #PhDone

[Sunada Khadka @KhadkaSunada]

@MelindaYatesPhD @em_a_thompson I’m sad I missed this. Thank you, Dr. Yates for your guidance and continuous support.

[UT MD Anderson UTHealth Houston Graduate School @MDA_UTHGrad]

Upcoming defense with hyperlink correction from The Essential:
PhD Public Seminar: Sunada Khadka
Wednesday, April 20, 1:30 p.m.
https://t.co/zmxMWucKHs

[Sunada Khadka @KhadkaSunada]

@MelindaYatesPhD @MDA_UTHGrad @em_a_thompson Indeed it was so nice to see you Dr. Yates. Hope you enjoyed the conference

[Sunada Khadka @KhadkaSunada]

Presenting my poster @ #AACR2022. Poster:3208, section 14, April 12 from 1:30-5pm. I’ll be presenting my work on the convergence of angiogenesis inhibition and tumor metabolism, and how we can leverage it for anti-tumor effect. See you all there!

[Muller Lab @Muller_Lab]

#AACR22 : my former student @KhadkaSunada is presenting her poster.
#3208 Tuesday, April 12, 2022, 1:30 PM-5:00 PM
She's presenting an intriguing story on how the long-hoped for efficacy of Angiogenesis inhibition may finally be realized (hint: gots to do with metabolism)

[Muller Lab @Muller_Lab]

#AACR22 : my former student @KhadkaSunada is presenting her poster.
#3208 Tuesday, April 12, 2022, 1:30 PM-5:00 PM
She's presenting an intriguing story on how the long-hoped for efficacy of Angiogenesis inhibition may finally be realized (hint: gots to do with metabolism)

[Sunada Khadka @KhadkaSunada]

The rate-limiting step of my PhD project. But glad that we now have a monoclonal antibody that can detect endogenous PANK3 protein.

[bioRxiv @biorxivpreprint]

Generation and validation of an anti-human PANK3 mouse monoclonal antibody https://t.co/cUbCBHhbKs #bioRxiv

[Dr. Holly Walters @Manigarm]

It's Kukur Tihar today in Nepal! My absolute favorite festival on the second day of Diwali. During #KukurTihar, we thank the dogs in our lives for their love and companionship with pujas, celebrations, and, of course, lots of treats!

(Photos by Sunil Sharma and Kathmandu Post)

[Erick Strauss @ErickStrauss_ZA]

So you think you know how that favorite tool cmpd/probe of yours works? Our paper just published in @ChemicalBiology shows that the enzyme thought to be the target of HoPan—a go-to molecule for modulating CoA levels—is actually its metabolic activator! https://t.co/csyYzY4Qq2