Sam Barritt

Runner-Scientist |
Dibble Lab @ HMS

[University of Vermont @uvmvermont]

UVM, partnering with @biolabs, will join an elite group of universities which currently house on-campus incubators, with the launch of a startup incubator for life science research at UVM’s Colchester facility. ⬇️
https://t.co/syjGBDGmYW

[Sam Barritt @SamBarrittYes]

@SarahPerlee @whitefishlab Congrats, Sarah!!

[The Arany lab @AranyLab]

We think this one is groundbreaking: Do you wonder how #SGLT2 inhibitors protect from heart failure? We show that #empagliflozen directly activates PANK1, rate-limiting for CoA synthesis, in human hearts. You read it here first! https://t.co/EAaKaI104X

[KayLee Steiner, PhD @steinerkaylee]

My first author paper from my thesis work has been uploaded to BioRxiv! We identified Mecr as important for T cell fitness in in vivo CRISPR screens. I have further worked with Mecr and am the first to show it regulates T cell function and metabolism.

https://t.co/AjHxEbLIlm

[Puigserver Lab @puigserver_lab]

New study from our lab and Hans Widlund in @CellReports mapping the metabolic routes of the sulfur amino acid cysteine establishing melanoma epigenetic states maintained by lysosome function, conferring resistance to ferroptosis and metastasis https://t.co/tqHXefuG5U

[Delgoffe Lab @DelgoffeLab]

New preprint from the lab is online! The product of a stellar collaboration with @Muir_Lab, we explore a chemically defined physiologic media formulation based of the metabolite of tumor interstitial fluid (TIF, or “tumor juice”) and its effects on T cell function! A brief 🧵1/

[Gerta Hoxhaj Lab @Gerta_Hoxhaj]

FOR THE LOVE OF PURINES: We are truly excited to share our latest work @CellPressNews on mapping the routes of purine nucleotide synthesis in vivo-De novo and Salvage Purine Synthesis Pathways Across Tissues and Tumors.https://t.co/SeBY4a11Op

[DeNicola Lab @LabDeNicola]

*New paper alert* I’m happy to share our latest study, out this week in @NatureComms. Led by former postdoc Nate Ward (who now leads his own lab at @MoffittNews), we asked how mitochondria cope with cystine starvation. https://t.co/saCLOT5uMe

[Greg Timblin @gtimblin]

Updated preprint up - direct supplementation with the metabolic cofactor Coenzyme A reverses macrophage immunosuppression + promotes pro-inflammatory & anti-microbial macrophage phenotypes via positive influence on CoA-dependent glucose metabolism (1/x) https://t.co/8HWXh9iczg

[Sam Barritt @SamBarrittYes]

@eclien Congrats Evan!

[Evan Lien @eclien]

Happy to share the first preprint from the lab! We describe how extracellular lipid availability regulates a polyunsaturated fatty acid trafficking pathway in cancer cells that influences ferroptosis sensitivity. Check it out! 👇
https://t.co/ZfvIyYRwuK

[Cantley Lab @CantleyLab]

We are delighted to share the #tyrosine @KinaseLibrary, now in @Nature: https://t.co/ZSwnymrBtb

Tyrosine predictions and enrichment analysis are now available: https://t.co/uPmrvbqD50

#TheKinaseLibrary #KL #part2

🧵

1/9

[Kathrin Lang @klanglab]

Genetically encoding negatively charged lysine PTMs succinylation/glutarylation and studying their funcional roles! Great team effort by first authors @ML_Jokisch and @Maria_Weyh! Congrats @Maria_Weyh @ML_Jokisch @MaxFottner and Anh! 🥳🤩🙌👨‍🔬🧑‍🔬 @klanglab
https://t.co/CKzQi1lavS

[Ben-Sahra Lab @bensahralab]

Excited to share our latest work revealing the requirements of pyrimidine nucleotides in the control of glucose oxidation and lipogenesis published in @ScienceMagazine. Huge congratulations to co-first authors Umakant Sahu and @VillaElodie! https://t.co/33FqVtSuiw

[Science Signaling @scisignal]

A second-generation degrader of the enzyme AKT—a key supporter of cancer cell proliferation and survival—can deplete AKT and halts breast cancer cell growth, especially in cells with basal JNK kinase activity. @alex_toker @BIDMChealth https://t.co/fROgwO6JC9

[Evan Noch @EvanNoch]

Excited to share our new paper out in @PNASNews https://t.co/Yqy1aFqBlY on cysteine susceptibility in #glioma. This was a long effort over years with @CantleyLab @Lnpalma @isaiah_yim Nayah Bullen @barnettd37 @JanKrumsiek @ElementoLab among others @WCMCNeurology @WCM_MeyerCancer

[Katherine Aird @airdlab]

Thrilled to share a new lab preprint spearheaded by superstar postdoc @ApoorvaUboveja in collaboration with @mzspectrum! We discovered something totally unexpected – aKG is important for histone acetylation! https://t.co/gxVY7t5iVt

[Sam Barritt @SamBarrittYes]

@KanarekNaama @KanarekLab @amaynard * @amaynard_

[Sam Barritt @SamBarrittYes]

@KanarekNaama @KanarekLab Congrats @amaynard and Naama!! I loved watching this story progress in our monthly "vita-meeting" ❤️

[Naama Kanarek @KanarekNaama]

***New Paper***** @KanarekLab: Is this early, aberrant erythroid differentiation induced by folate depletion part of a molecular mechanism of nutritional anemia?
check it out - Out today in Science Advances https://t.co/X2Y2WGRYmd