Kimmo Aro

Research Collaborations @NgaleHealth Disease prevention enthusiast. Genetics and metabolomics.

[UK Biobank @uk_biobank]

There’s just 3️⃣ days to go until our annual Scientific Conference in London!

There’s still time to register to watch online, or if you’ve already registered, prepare for the day by viewing the agenda: https://t.co/km9mWMVoKI #UKBSC24

[Kimmo Aro @kihear]

Long awaited peer review finally completed!! Our paper comparing quantitative metabolomics disease risk prediction with PGS is accepted in Nature Comms!! ���🥳

https://t.co/vUI28vodSX

@NgaleHealth #riskprediction #metabolomics #nmr #genomics #polygenicscore

[Nightingale Health @NgaleHealth]

Are you coming to ESC Congress 2024 on August 30 - September 2? We'll have a talk and a poster by our Chief Scientific Officer @jcbarret. You can also meet Nightingale team at our booth G490.

Learn more: https://t.co/iNAMXJUnbq

[Kimmo Aro @kihear]

First day at #ESHG2024 beginning! Ready to demonstrate the power of metabolomics in genetic studies.
@NgaleHealth at booth 526 near the central coffee spot, so grab a coffee and let’s chat.

[Nightingale Health @NgaleHealth]

Are you coming to ESHG 2024 on June 1-4? We'll have a presentation by our Principal Scientist Luke Jostins-Dean and a poster by our Chief Scientific Officer Jeffrey Barrett. You can also meet Nightingale team at our booth 526.

[Prof M Ala-Korpela @mak_sysepi]

Some 7 years of work & some 90 co-authors. 33 populations; up to 136,000 people + confirmations in 120,000 (UKB). 233 blood biomarkers and +13M SNPs. Multiple novel metabolic findings + a pile of data and genetic instruments as a gift to others! Enjoy 🥳
https://t.co/7rjed5gc8C

[Kimmo Aro @kihear]

@timoaro @Ilmastosankari @HublinPatrick @MalinenPentti @MDIfriends Uskon että rataosuudella on merkittävää korjaus- ja huoltovelkaa, mutta omakohtaisen kokemuksen pohjalta 7 vuoden ajalta sanoisin yhteyden tällä hetkellä olevan erittäin luotettava. Monesti viivästykset johtuu Helsingin alueen teknisistä turvalaiteongelmista.

[Kimmo Aro @kihear]

@timoaro @HublinPatrick @MalinenPentti @Ilmastosankari @MDIfriends Matkustan väliä 4 kertaa viikossa. Ainoa mitä on ikävä on toimiva internet-yhteys. Monet kanssamatkustajat ovat täysin samaa mieltä, mutta ymmärrän kyllä että toisille 20 minuutin ajansäästö voi olla jopa kriittisempi asia. Radan puutteista huolimatta myöhästymisiä vain harvoin.

[Nightingale Health @NgaleHealth]

Welcome to our webinar Understanding disease risk and progression from the complete metabolomic profiling of the UK Biobank cohort on 7th February at 2 p.m. GMT!

In this webinar, you will learn about Nightingale Health’s effort to create metabolomic blood profiles for half a million individuals in the UK Biobank by our Principal Scientist @lukejostins.

Learn more about the webinar and sign up: https://t.co/eEQ6sYEobH

We will also send a recording to all participants after the webinar.

[Nightingale Health @NgaleHealth]

📣 We have reached a significant milestone by completing the analysis of all 500,000 @uk_biobank samples. This accomplishment creates the world's largest blood biomarker database, advancing research and prevention of chronic diseases.

Renowned for its vast and continuously growing dataset of biological, health, and lifestyle data, the UK Biobank is an invaluable resource for over 30,000 researchers from over 90 countries. By making the analysis results from 500,000 samples available via the UK Biobank, we further solidify our role as the leading source of blood biomarker data for scientific research.

The broad scientific use of Nightingale Health's biomarkers has also facilitated the use of our technology in clinical settings. This is demonstrated in our collaborations with @Terveystalo in Finland and Innoquest Diagnostics and Pathology Asia in Southeast Asia, marking a new era in preventative healthcare.

Read the full press release: https://t.co/AHLHcDmdGw

[Nightingale Health @NgaleHealth]

Are you attending the @NutritionSoc 's Winter Conference 2023 next week (December 5-6, 2023)?

Healthcare systems face a cost crisis as they try to provide an increasingly wide range of transformative but expensive treatments to the older, sicker populations. Better prevention, to complement new treatments, is essential to provide healthier lives and sustainable healthcare.

Breakfast symposium supported by Nightingale Health (details below) will feature two speakers describing how large-scale multi-omics can be used to understand who is at highest risk for future diseases, and how factors like diet, lifestyle, and response to stress can influence and reduce that risk:

Breakfast symposiums: Using large-scale multi-omics to understand, predict, and prevent chronic disease

Date and time: 6 December 2023 at 8:00 a.m.

Speakers:

Dr. Luke Jostins-Dean will present nuclear magnetic resonance metabolomics from half a million blood samples from three national biobanks. He will show how metabolomic risk scores can identify individuals at high risk of 12 diseases that cause the most morbidity, and compare to genetic risk scores for the same diseases. For seven diseases (heart attack, stroke, lung cancer, type 2 diabetes, COPD, alcoholic liver disease, and liver cirrhosis) this high risk group has > 3-fold increased risk of disease (ranging up to 10-fold for diabetes and liver disease), and there are existing medical and lifestyle interventions available to reduce future risk.

Dr. Kate Bermingham will present results from the PREDICT-1 study of 1000 individuals, exploring anthropometric measurements, diet and gut microbiome data, and fasting and postprandial cardiometabolic blood measurements among different population groups (e.g. post-menopausal women), and how they react in response to diet.

Read more: https://t.co/r2ILcTPPeO

[Nightingale Health @NgaleHealth]

Nightingale Health for Research: Which disease risks can be detected with Nightingale Health biomarkers?

Nightingale Health Biobank Collaborative Group’s recent pre-print (link below) shows how metabolomic risk scores can be used to identify individuals at high risk of nearly any of the 12 leading causes of disability-adjusted life years (DALY) in Europe. The study included blood samples from almost half a million individuals across three national biobanks (UK Biobank, Estonian Biobank, Finnish THL Biobank) and is the world's largest study combining blood biomarkers and genetics. 

The picture illustrates that for nearly all diseases studied, if an individual’s metabolomic risk score was in the top 10% of risk (shaded in red), they were considerably more likely to be diagnosed with that disease in the following 4 years. These results show that Nightingale Health biomarkers excellently predict common chronic diseases such as type 2 diabetes and heart diseases as well as liver disease and lung cancer. 

Access these and many other interesting results from Nightingale Health Biobank Collaborative Group’s pre-print here: https://t.co/do3XUsfByi

Picture: Nightingale Health Biobank Collaborative Group, 2023, Metabolomic and genomic prediction of common diseases in 477,706 participants in three national biobanks, Fig.1

[Nightingale Health @NgaleHealth]

What's the connection between Nightingale's biomarkers, smoking, and lung cancer?

In our recent research blog post, we discover what blood reveals about smoking status. From the UK Biobank data, we learned how our blood biomarkers predict lung cancer compared to pack-years of smoking. Learn more from our blog post: https://t.co/Resx2cAp7F

[Kimmo Aro @kihear]

Novel research potential incoming for MGB affiliates! Extremely excited about this collaboration!!

[Nightingale Health @NgaleHealth]

Nightingale Health has entered into an agreement in which Mass General Brigham orders analysis services for blood samples from Nightingale Health.

Mass General Brigham’s institutions are known for their research-infused care, and the agreement will make critical biomarker data available to researchers as they work to bring scientific findings to the healthcare setting in an effort to improve patient outcomes.

“The Mass General Brigham Biobank is a research resource at Mass General Brigham that has provided hundreds of researchers throughout our system with samples and genomic information,” said Elizabeth Karlson, MD, principal investigator of the Mass General Brigham Biobank. “The addition of these biomarker data will further support many teams that are investigating critical disease areas.”

Read the full release: https://t.co/iT7fBenlbe

[Kimmo Aro @kihear]

@Reijo_RD_FIN Löytyy varmastikin koko artikkelista, mutta mikä persentiili oli määritetty korkean riskin kategoriaan PRS:lla?

[Kimmo Aro @kihear]

@saarijuh @VesaHeikkila Tämä!! Kyseisellä pätkällä usein matkaavana koen että edes ajoittain toimiva nettiyhteys parantaisi työmatkaliikenteen toimivuutta huomattavasti enemmän kuin 15 minuutin ajansäästö per suunta.

[Kimmo Aro @kihear]

See you at @EASCongress next week in Mannheim, Germany!

[Nightingale Health @NgaleHealth]

Join us @EASCongress 2023 to explore the new gold standard for clinical biomarkers in research, with risk markers for cardiometabolic diseases and beyond!

Discuss replicating & publishing research with 450+ publications from @uk_biobank and other cohorts.

#EASCongress2023

[Kimmo Aro @kihear]

@RitaTainola @Finnair @qatarairways Bisnes on makuuasentoon taittuva jakkara ja lounge access. Välipalalla pärjää kivasti kentältä ulos. Eihän kukaan tuonne koneeseen ruokailemaan mene, vai meneekö? Arvostan Finskin korkealle kaluston ja 1. rivin henksun ansiosta, vaikka Qatarissa on enemmän blingiä ja luksusta.

[Nightingale Health @NgaleHealth]

Greetings from ESC Preventive Cardiology Congress in Malaga!

If you are at the event, come meet our team at booth #A7 to hear about our next-generation clinical chemistry offering and our new remote blood collection kit for medical research and clinical trials.

[Kimmo Aro @kihear]

@Okahkonen @VesaHeikkila Viitisen vuotta väliä sahanneena, nykyinen yhteys toimii hyvin ja kulkee pääsääntöisesti ajallaan. Lyhyempi matka-aika olisi luksusta, muttei mitenkään välttämätöntä. Parempi nettiyhteys tai työappien priorisointi verkossa toisi suuremman suhteellisen hyödyn.