🏋️♂️🏃📢 Can physical fitness buffer the effect of age on the brain?
In 920 older adults at elevated dementia risk (CITA GO-ON trial), faster gait speed, stronger grip and greater leg power were associated with a weaker age–executive function link, independent of SES, depression, BMI and cardiometabolic factors. Gait speed was the most consistent marker.
Cross-sectional, and the Johnson-Neyman thresholds are sample-specific, not clinical cut-offs. Longitudinal studies are needed.
📄 Open access in #JCSM: https://t.co/1qPTjeumUJ
#Ageing #Dementia #ExecutiveFunction #GaitSpeed #Sarcopenia #ExerciseIsMedicine @DementiaUK@DementiaAus@raulmarcus@CIBER_ISCIII@EricTopol
Meta-analysis of 21 randomized trials of exercise interventions in adults with cancer showed significant association with OS, DFS, cancer-specific and all-cause mortality. More benefit seen with higher adherence, aerobic exercise, early-stage disease.
https://t.co/HYHgV2Fcf4
A massive new meta-analysis @Nature of 67 datasets and over 8,000 people found that moving 🏃🏾♀️more in daily life is consistently linked to feeling more energetic, positive, and generally good.
Interestingly, #physicalactivity was tied to feeling more energetic and positive but less calm, while it showed no reliable link to negative emotions like sadness or anxiety.
The effects were comparable to other daily activities like listening to music, and they varied between people with older adults and those with higher BMI showing weaker positive emotional responses to activity.
Movement and #mood appear to reinforce each other in everyday life, and understanding this loop could help shape more personalized health strategies.
https://t.co/MjrsuI52rN
🚨 Different daily step count and stepping pace combos may all lower risk of early death 🚶♂️ 👣
This brand new original research article is a #MustRead 📄 ✅
Link ➡️ https://t.co/jpryJMa2Mp
Intensity matters. 🚶♂️🚴♂️🏃♂️
~510 min/week light, 150 min moderate, or just ~12 min vigorous activity showed similar associations with lower mortality.
More intensity = more health per minute. Observational ≠ causal.
https://t.co/BjOBGr0p4Z
Effects of Resistance Training Sets on Cognition and Brain-Derived Neurotrophic Factor in Cognitively Impaired Individuals: A Quasi-Experimental Study https://t.co/mecwgJwHQ7 @DrGustavoDuque#Vivifrail
Among cognitively unimpaired older adults, very high plasma #PTau217 levels were associated with a 38% risk of progression to #CognitiveImpairment within five years.
https://t.co/Z8hvfQAknZ