Stephan Köstlbacher

he/him
Postdoc w/ @Ettema_lab at @WUR looking into the past of microbes without a DeLorean
@stephkoe.bsky.social

[Stephan Köstlbacher @koestlste]

🚀 Identifying new eukaryotic signature proteins in Asgard archaea has been a fun, exciting, at times overwhelming (so many protein structures) but fulfilling ride so far with @Ettema_lab at @MIB_WUR

[Thijs J. G. Ettema 🦠🔬🇳🇱🇸🇪🇪🇺 @Ettema_lab]

Our latest: Using de novo protein structure prediction and sensitive sequence searches we found many new eukaryotic signature proteins in Asgard archaea, suggesting the archaeal ancestor of eukaryotes was more complex than previously assumed. @koestlste https://t.co/SoxnBM2Iu6

[Sara Cantera @SCantera1]

Interested in extremophiles, circular economy, novel genomic tools and biotechnology?🦠🏞️ looking for a lab to do a postdoc? 🤓 our lab invites applicants for the following call: #JuanDeLaCierva from @AgEInves https://t.co/Mf0FYQit3e. PM for more info.

[IMPRS-μLife @IMPRS_Mic]

📢We invite candidates strongly interested in 𝗶𝗻𝘁𝗲𝗿𝗱𝗶𝘀𝗰𝗶𝗽𝗹𝗶𝗻𝗮𝗿𝘆 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗶𝗻 𝗺𝗼𝗱𝗲𝗿𝗻 𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗼𝗹𝗼𝗴𝘆 to apply for 𝗳𝘂𝗹𝗹𝘆-𝗳𝘂𝗻𝗱𝗲𝗱 𝗣𝗵𝗗 𝗽𝗼𝘀𝗶𝘁𝗶𝗼𝗻𝘀.

Curious to learn more? See this 🧵 or visit
https://t.co/LK4HqAQ9My

[Fatima Pereira @microbetracker]

Our study on drug-gut microbiome interactions is out! 🦠💊 @NatureMicrobiol

We show that the #Parkinson's drug entacapone induces iron deficiency in microbes, leading to selective inhibition of microbial activity.

Check the full story here: https://t.co/xZAKK1dXBE

[Cameron Thrash @jcamthrash]

Microbial species and intraspecies units exist and are maintained by ecological cohesiveness coupled to high homologous recombination https://t.co/9KqoXukhrp

[Akos T. Kovacs @EvolvedBiofilm]

Genome dynamics across the evolutionary transition to endosymbiosis

@CurrentBiology by @sio_stef et al from Gregory Hurst @TheLadybirdman

with @acdarby, @kaylacking, Mike Brockhurst

https://t.co/I827PAtAAs

[Jon Hultqvist @jon_hultqvist]

How can a symbiont be located at the center of a host cell while still being an epibiont!?

Please read and be astonished about the symbiosis between Anaerameoba and sulfate-reducing bacteria!

Now out in Nature Communications!

https://t.co/kAds12xR0M

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[Universität Wien @univienna]

Ein @ERC_Research Synergy Grant, der mit 9,9 Millionen Euro dotiert ist, geht an ein internationales Team – 2,5 Millionen Euro davon erhält die Mikrobiologin Katharina Kitzinger von der Uni Wien.🎉
Mehr dazu: ⤵
https://t.co/hzx8Wh6h9z

[Thijs J. G. Ettema 🦠🔬🇳🇱🇸🇪🇪🇺 @Ettema_lab]

Three weeks left to apply for this exciting PhD position focusing on eukaryotic genome evolution! Come work with us at @MIB_WUR! Please RT #PhDposition #evolution @WUR 🦠🧬🧐

[Stephan Köstlbacher @koestlste]

🚨 New preprint alert! 🚨
Our latest work on Escherichia coli and the regulation of DNA replication initiation via DnaA titration on the chromosome, led by Lorenzo Olivi. Here’s a thread summarizing our findings. 🧵👇 @WUR @Ettema_lab @HohlbeinLab et al. https://t.co/A1qJ8aYShg

[Laboratory of Microbiology at WUR @MIB_WUR]

Now online the latest work of Lorenzo Olivi, @koestlste @NicoC_MicSynBio @Ettema_lab @HohlbeinLab et al.

https://t.co/pEEZS8Cjxd

[Nico Claassens @NicoC_MicSynBio]

New preprint out showing exciting insights on how genome replication is controlled in E. coli, also by titration!Great work led by the amazing Lorenzo Olivi and great bioinformatics by @koestlste @MIB_WUR . And great collaborations with @HohlbeinLab Pieter-Rein ten Wolde @_amolf

[Seki David @Sekifilipdavid]

New study in: https://t.co/ZFy5mC1JjQ Using nanopore sequencing, we identified microbial traits linked to severe brain injury in preterm infants. Enterobacteriaceae predominance ties to poor neurodevelopment, revealing potential therapeutic targets! 🧠 #Microbiome #Brain

[Thijs J. G. Ettema 🦠🔬🇳🇱🇸🇪🇪🇺 @Ettema_lab]

Great work by Lorenzo Olivi, @koestlste and other colleagues from @MIB_WUR, reporting experimental and computational evidence for titration-based replication control in E. coli!

[Stephan Köstlbacher @koestlste]

Our findings pave the way for further studies on how chromosomal organization and DnaA dynamics contribute to the control of DNA replication. Stay tuned for more! 📚
Read the full preprint here: https://t.co/A1qJ8aYShg
#DNAReplication #Ecoli #DnaA #Genomics #Preprint

[Stephan Köstlbacher @koestlste]

🚨 New preprint alert! 🚨
Our latest work on Escherichia coli and the regulation of DNA replication initiation via DnaA titration on the chromosome, led by Lorenzo Olivi. Here’s a thread summarizing our findings. 🧵👇 @WUR @Ettema_lab @HohlbeinLab et al. https://t.co/A1qJ8aYShg

[Stephan Köstlbacher @koestlste]

This study provides the first experimental evidence of DnaA titration on the chromosome in E. coli. This titration helps stabilize DNA replication initiation, especially in slow-growing cells, preventing premature re-initiation events. 🧬🔒