Koutmos Lab

Protein and RNA crystallography research lab at the University of Michigan | Student-run account

[Koutmos Lab @KoutmosLab]

We are the Koutmos lab at @MichiganChem. We use x-ray crystallography to investigate protein and RNA structure in many contexts, including metalloenzyme chemistry, RNA processing, and ribozyme function/dynamics. We're excited to share research news with our colleagues on Twitter!

[Koutmos Lab @KoutmosLab]

Johnny Mendoza successfully defended his thesis this past November! All his hard work really paid off! Congratulations Johnny! We are excited to see what you do next! 🥳🎂🎊

[Koutmos Lab @KoutmosLab]

SPOTTED: the Koutmos Lab at the Rustbelt RNA Meeting

Congratulations to everyone who gave a poster/presentation! Looking forward to the next meeting @RRM_RNA

[Koutmos Lab @KoutmosLab]

5 years of growth in the Koutmos Lab! 💪

[Koutmos Lab @KoutmosLab]

Markos' tenure talk is today! Join us at 4pm in CHEM 1640 to learn about the variety of projects in the lab - from B12/metalloenzymes to RNA modifications to riboswitches!

[Shah Lab @YatrikShahLab]

Extremely proud of @SDeangelo95, a Ph. D student in @YatrikShahLab and @KoutmosLab for successfully defending and giving an awesome dissertation presentation.

Congrats Dr. DeAngelo 🎉🎉🎉!

[Koutmos Lab @KoutmosLab]

Congratulations, Dr. Stephen DeAngelo! Steve just defended his thesis on the role of the selenoproteome in colorectal cancer. He has been such a wealth of knowledge in our lab, and we can't wait to see his future work!

[Koutmos Lab @KoutmosLab]

Congratulations, Dr. Elizabeth Tidwell and Dr. Catherine Wilhelm!

[Koutmos Lab @KoutmosLab]

Congratulations to Jacqui (left), Matt (right), and Bella (not pictured) for their awards from the @MichiganChem Department! We are so fortunate to be working with such dedicated and enthusiastic undergraduate researchers. Thanks for being awesome!

[Koutmos Lab @KoutmosLab]

Congratulations to Dr. Catherine Wilhelm for defending her thesis in Chemistry in March! We have been so lucky to have her for the past several years! Go Cat!!! 🥳

[Koutmos Lab @KoutmosLab]

You can also check out Bella's poster showcasing her work making and characterizing mitochondrial tRNAs at the @URSymposium in the @MichiganChem atrium!

[Koutmos Lab @KoutmosLab]

Check out Matt's poster covering his work on the tRNA methyltransferase TRMT1 at the @URSymposium in the @MichiganChem atrium!

[Koutmos Lab @KoutmosLab]

We are thrilled to announce our latest review article about PRORPs in @WIREs_Reviews: "The protein-only RNase Ps, endonucleases that cleave pre-tRNA...". You can read more about it at the link below! 😄
https://t.co/wF2beg4OPE

[Koutmos Lab @KoutmosLab]

Congrats, Steve! 🥳 Steve has done a great job tying together both cancer biology (@YatrikShahLab) and protein biochemistry (our lab), and he has given our lab a big appreciation how RNA mods play a role in cancer. This work has been a long time in the making!

[Steve DeAngelo @SDeangelo95]

Thrilled to share that my thesis work on #ferroptosis is now live on @biorxivpreprint!

Here in the @YatrikShahLab we show that RSL3 is a non-selective inhibitor of the Selenoproteome, revealing new therapeutic opportunities in #colorectalcancer

https://t.co/6xuxGlTDvM

[Koutmos Lab @KoutmosLab]

Markos visited UPenn this week and met up with not one, but *two* lab alumni! 🤩 Leena (left) is now a research scientist in the @SgourakisLab, and Shayna (right) is now a grad student at @BMBGGUPENN!

[Koutmos Lab @KoutmosLab]

Congratulations to Dr. Liz Tidwell for defending her thesis in Biophysics in November!
You can read about it in @IJMS_MDPI: Fluorescent Ligand Equilibrium Displacement: A High-Throughput Method for Identification of FMN Riboswitch-Binding Small Molecules.
https://t.co/tojnaEZKVj

[Koutmos Lab @KoutmosLab]

This weekend marked yet another successful Rustbelt RNA Meeting (@RRM_RNA)! Congratulations to Catherine Wilhelm and Liz Tidwell for their talk and poster awards! Keep an eye out for news about the 2024 Rustbelt RNA Meeting, which Markos will help co-chair 😄

[Koutmos Lab @KoutmosLab]

A lot of hard work is coming to fruition recently!
Here's our recent @NatureComms article on Methionine Synthase (MS) using a thermophilic model to understand how it orchestrates large multi-domain rearrangements.
https://t.co/eSqYosF4v4

[Koutmos Lab @KoutmosLab]

We're excited to announce our newest paper in @jbiolchem: Bacterial RNA-free RNase P: structural and functional characterization of multiple oligomeric forms of a minimal protein-only ribonuclease P. Learn more about this beauty in the pre-proof version:
https://t.co/wJKu3fGKzj

[Michigan Chemistry @MichiganChem]

Many #MichiganChem labs celebrate the end of a great summer with a group picnic! ☀️

To highlight a few, here are some photos from the Walter, Sanford, Koutmos, and Shultz labs!

@NilsWalterLab @KoutmosLab @Sanford_Lab @ShultzGroupCER

[Koutmos Lab @KoutmosLab]

We had a fantastic time kayaking down the river to celebrate the end of summer, along with welcoming our newest rotation student Alice Youle! 🛶☀️