Kshitiz Lab

Dr. Kshitiz Gupta Cancer Research Lab at the University of Connecticut Health Center. We focus on Cell-Cell Communication with a focus on Tumor Microenvironment

[Kshitiz Lab @KshitizLab]

Our continued research connecting pregnancy and metastatic cancer was recently covered by Scientific American Magazine.
@sciam

#research #cancer #CancerResearch #biology #medicine #MedTwitter #biotech #STEM #StemEducation #ScienceTwitter

https://t.co/3ZPXOQ9kX9

[Stem Cell Podcast @stemcellpodcast]

These #cardiomyocytes are mature for their age!

The @KshitizLab at @UConn used cardiac mimetic matrix to generate cardiomyocytes with adult-like characteristics and model pathological #hypertrophy. 🫀

@CellReports paper: https://t.co/qRRhtz5KXA
Episode: https://t.co/8LTIiAaPPH

[Arun Sharma @ArunSharmaPhD]

And in the roundup:
1) Modeling polycystic kidney disease 🫘
@TTdevbio @USCStemCell

2) Generating mature myocytes ♥️
@KshitizLab @JunaidAfzal_etc

3) Tracking T cells in organoids 🔍
@_Hubrecht @NatureBiotech

4) MSCs in the aorta 🧫
@UNSWMedicine

[Kshitiz Lab @KshitizLab]

@sciam Congratulations to @KshitizKz, Gunter Wagner, @YasirSuhail7, and the rest of the team members for such groundbreaking work and recognition.

#research #cancer #CancerResearch #biology #medicine #MedTwitter #biotech #STEM #StemEducation #ScienceTwitter

[Kshitiz Lab @KshitizLab]

Our continued research connecting pregnancy and metastatic cancer was recently covered by Scientific American Magazine.
@sciam

#research #cancer #CancerResearch #biology #medicine #MedTwitter #biotech #STEM #StemEducation #ScienceTwitter

https://t.co/3ZPXOQ9kX9

[Kshitiz Lab @KshitizLab]

Our paper from July 2022 presents "rapid iPSC-CM maturation on surfaces mimicking native cardiac microenvironment" and "concurrent metabolic and redox maturation on cardiac mimetic matrix (CMM)"
@JunaidAfzal_etc

#research #medicine #biology #STEM #cells
https://t.co/JsExLEBYU1

[Kshitiz Lab @KshitizLab]

The cow in your body. The more cow (or if you prefer horses) like we are inside, the more it prevents cancer spread.
#Cancer #CancerResearch #animalscience #animals #metastasis #research #Biology #MedTwitter #MedEd #medicine #nature #cow #horse #science

https://t.co/etglGvmhwq

[Kshitiz Lab @KshitizLab]

@Sarah_E_Pierce @JeffreyGranja @WJGreenleaf @LabWinslow @RuiTang16 @HowardYChang This work elegantly demonstrates how the downstream effects of an individual driver mutation can change throughout #cancer development, with implications for stage-specific therapeutic resistance mechanisms and the gene regulatory underpinnings of metastatic evolution. #health

[Kshitiz Lab @KshitizLab]

Metastasis is the leading cause of cancer-related deaths and enables cancer cells to compromise organ function by expanding in secondary sites.
@Sarah_E_Pierce @JeffreyGranja @WJGreenleaf @LabWinslow @RuiTang16 @HowardYChang

#cancer #research
Source: https://t.co/AlN1RQfcnX

[Kshitiz Lab @KshitizLab]

@Sarah_E_Pierce @JeffreyGranja @WJGreenleaf @LabWinslow @RuiTang16 @HowardYChang Scientists found that the tumor suppressor gene LKB1 is frequently inactivated and identify LKB1 as a master regulator of chromatin accessibility and pro-metastasis factor.

#ScienceTwitter #CancerResearch #MedTwitter #educational #stem #regeneration #health #laboratory #biotech

[Kshitiz Lab @KshitizLab]

Developed LATS inhibitors that effectively suppress the expression of ESR1, providing new potential therapeutic targets for ER+ breast cancer, particularly those with hormone therapy-resistant ESR1 mutations.

#research #cancer #biology #science #STEM #STEMeducation #education

[Kshitiz Lab @KshitizLab]

Drugs targeting advanced breast cancers associated with mutant ERα represent a major unmet medical need.
@SilvioGutkind

#stroma #tumor #evolutionarymedicine #systemsbiology #cancer #medicine #MedTwitter #researchpaper #science #health #data

source: https://t.co/KTdXLtea2g

[Kshitiz Lab @KshitizLab]

@SilvioGutkind The authors delineated the mechanism of ESR1 transcriptional repression by the LATS-YAP-TEAD-VGLL3 axis.

#ScienceTwitter #CancerResearch #MedTwitter #educational #facts #study #stem #regeneration #health #laboratory #biotech #cancer #fibroblast #biology #nature #breastcancer

[Kshitiz Lab @KshitizLab]

So an organ can be predisposed to get cancer by inflammation, or bad repair.

#ScienceTwitter #CancerResearch #MedTwitter #educational #facts #study #stem #regeneration #health #laboratory #evolutionarymedicine #cancer #fibroblast #inflammation #repair #tissuerepair

[Kshitiz Lab @KshitizLab]

Tissue repair and cancer are linked.
@thecrick @IMalanchi @ScienceDaily

#stroma #fibroblast #cancerenvironment #tumor #evolutionarymedicine #systemsbiology #inflammation #cancer #medicine #MedTwitter #researchpaper #science #health #data
Source: https://t.co/lu4Mq3bCa2

[Kshitiz Lab @KshitizLab]

Scientists at Francis and Crick Institute found that the relationship between immune response and cancer is very complex. And it is their communication that can make cancer spread.
@thecrick @IMalanchi @ScienceDaily

#cancer #biology #technology #healthcare #ScienceTwitter

[Kshitiz Lab @KshitizLab]

Cancer is not merely mutations getting accumulated. They can arise because of the "wrong repair" of healthy tissue. Finally, fibroblasts and inflammation are playing a central role in cancer.

#stroma #fibroblast #cancer #tumor #medicine #biology #research

[Kshitiz Lab @KshitizLab]

Our paper connecting pregnancy to cancer malignancy is out in PNAS.
The paper details how pregnancy has evolved in mammals with direct effect on cancer metastasis in humans.
https://t.co/EOuVxNGm1p