Abhi

Consultant Microbiologist/infection specialist at Sandwell and West Birmingham NHS Trust supporting Black Country Pathology Service ( BCPS)

[Abhi @kumar_drabhi]

@ABsteward @NEJMEvidence @DrToddLee @BradSpellberg I think we need a head to head study comparing
1. Standard vancomycin first line vs Fidaxomicin TP
2 Van TP vs fidaxomicin TP

[Abhi @kumar_drabhi]

@AngryMacarons @alejodiaz81 @ABsteward Can you please help me with the access Thanks

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕️⚡️🔥State of the Art Review article @CIDJournal
🌟s @SandyNelsonMD @DrAntoniaChen @PinkneyJodian
@MDTande
Periprosthetic Joint Infection: Current Clinical Challenges
Excellent figures🎯
cc @Cortes_Penfield @aurdinh
#IDTwitter #orthotwitter #PJIs https://t.co/w8AOLJbn11

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕️⚡️🔥 @CIDJournal @ErinMcCreary
Antibiotic Myths for the Infectious Diseases Clinician
With 🌟s @tmjones6 @IDPharmacist @JGPharmD
@aprildyerid @The_Real_LDA @ShaeferSpires #IDTwitter
https://t.co/UXXXtUSAoN

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

If you don't have full access to the article, follow me, like and RT the post below, DM me, and I'll send you the link #IDTwitter

[Abhi @kumar_drabhi]

Very well said Prashant . AMR is the silent pandemic and a real challenge which is still overlooked and under appreciated . Newer antibiotics pipeline is virtually dry so preserving reserve antibiotics is even more important than ever !!

[Prashant Mehta @Prasshmehta]

We need to discuss with ID physicians and microbiologists before prescribing reserve antibiotics, please pick up that phone and talk. No hospital is complete without good ID physicians. These are very important people to save the world from super-bugs , listen to them everyday

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

The first daptomycin physiologically based pharmacokinetic (PBPK) /pharmacodynamic model for bone and joint infection, confirmed that a higher daptomycin dosage(≥12 mg/kg) is needed to optimize exposure in bone tissue #IDTwitter #TwitteRx #MedEd
https://t.co/yCX4XCE4kR

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

Super interesting💥
🆕💥Case report @CIDJournal @IDSAInfo
Emergence of dalbavancin, vancomycin, and daptomycin non-susceptible Staphylococcus aureus in a patient treated with dalbavancin #IDTwitter #MedEd #TwitteRx
Wow first time ever to use @CIDJournal https://t.co/o69mvYntS0

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕💥💥Systematic Review & Meta-Analysis @CMIJournal @tonybai16 @DrToddLee
Staphylococcus aureus bacteremia mortality
SAB mortality has decreased over the last 3 decades. However, more than 1 in 4 patients will die within 3 months😱
MRSA > MSSA #IDTwitter
https://t.co/TuGn2wM23A

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕💥Cohort study @Crit_Care , Dexamethasone therapy was associated with a significant three times increase in the risk of COVID-19-associated pulmonary aspergillosis (CAPA) in intensive care patients #IDTwitter #medtwitter #TwitteRx #MedEd
https://t.co/PJGazdSiLu

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕💥Small retrospective study @InfectDis_Ther
Treatment of patients with #COVID19 with tocilizumab does not increase the risk of bacteremia. Tocilizumab suppresses C-reactive protein levels but not fever. https://t.co/ASNGz7vred

[Brad Spellberg @BradSpellberg]

Another short course CAP RCT, for kids! That's 14 short course CAP trials now--all showing the same thing!

Updated table and link below:
https://t.co/1oaAT6koX3

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

Is there an association between invasive dental procedures (IDP) and late PJIs in patients who did not receive antibiotic prophylaxis prior to IDP?
This 🆕💥💥 study @jamanetworkopen might provide the answer #IDTwitter https://t.co/XasKlMLJuz

[FungalDoc: moved to bluesky @FungalDoc]

Do you die with Candida or from Candida? Turns out mostly from Candida. Attributable mortality from candida is higher than total mortality for Staph aureus.

A study from @WU_Mycoses with @PBMazi . A thread

https://t.co/KOB2MUu0dX

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

NIH UPDATE💥💥
Outpatient treatment Options (in order of preference):
Paxlovid orally twice daily for 5 days
Sotrovimab 500 mg IV single dose
Remdesivir 200 mg IV on Day 1, then 100 mg IV on D2 & 3
Molnupiravir 800 mg twice daily orally for 5d
NO fluvox
https://t.co/H88pHmGly6

[Jonathan Ryder, MD @JonathanRyderMD]

Paxlovid (nirmatrelvir/ritonavir) contains ritonavir, a "booster" which has multiple drug-drug interactions. This is a great chart for determining which medications are absolute and relative contraindications to this regimen!

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

@IDstewardship @PharmacyPosts @KisgenUF @CarlosdelRio7 @Dr_Mike_Stevens @khalideljaaly @luckytran @trvrb @BogochIsaac @PeterHotez Excellent table my friend, but would add efficacy data if not already there
Pfizer's Paxlovid has 88% efficacy in preventing COVID-19 hospitalisations and deaths in high-risk patients.
Merck's Molnupiravir was markedly reduced 30%.

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

Antibiotics should be given to patients with exacerbations of COPD who have 3 cardinal symptoms:⬆️dyspnea,sputum volume& sputum purulence,
have 2 of cardinal symptoms, if ⬆️ purulence of sputum is 1 of the 2 symptoms;or require mech vent
Oral is preferred💥
Duration :5-7 days 😱

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

Sotrovimab Vs Omicron preprint
All therapeutic antibodies tested, significant neutralization was only observed for Sotrovimab, with other monoclonals unable to neutralize Omicron #IDTwitter #medtwitter #TwitteRx #MedEd
https://t.co/DG1raWH0ae

[Abhi @kumar_drabhi]

@GKangInd My parents had both doses of Covishield 6 months ago , are they eligible to participate ? Thanks