Kusal Samarasinghe

Postdoc @Yale 🇱🇰 🇺🇸

[Nature Chemical Biology @nchembio]

A new Review highlights the mechanisms of molecules that disrupt translation in an amino acid or mRNA sequence-dependent manner

https://t.co/2fcySo7LoI

[nature @Nature]

Mark Chen, chief research officer at OpenAI, sat down with Nature to discuss how AI will affect science, along with the firm’s pivot towards safety

https://t.co/vHwYyEgod4

[Daniel Gerlach @gerlach_d]

Selective Inhibition of KRASG13C Reveals an Increased Dependence on Wild-type RAS Isoforms in Codon 13 RAS-Mutant Cancers https://t.co/Bj269tYKbk

[Nature Rev Immunol @NatRevImmunol]

The next big questions in immunology https://t.co/JPTwmdi9Ej

[Waggoner Lab @LabWaggoner]

Targeting ZMYND8 unleashes IL-2 signalling to override T cell exhaustion @Nature @hongbo_chi @StJudeResearch
https://t.co/dXr5JSOC9c

[ShorterLab @ShorterLab]

A design approach for bitopic kinase inhibitors: https://t.co/ArsBxYDMpR

[Jonathan Kagan @jkagan1]

Today, the Toll-like Receptors reveal a new mechanism of signal transduction: Receptor-Free Signal Transduction.
https://t.co/AqzQvvMLRs

[St. Jude Research @StJudeResearch]

St. Jude scientists identified ZMYND8 as a major regulator of CD8+ T-cell exhaustion. Targeting the gene improved immune function and enhanced immunotherapy, offering a potential new strategy to strengthen anti-tumor responses in solid tumors. https://t.co/IcGyfQADmN

[Jeffrey Millman @JeffreyRMillman]

Excited to share our new paper! We used CRISPR-edited, T1D patient-derived stem cell islets to uncover how a protective IFIH1/MDA5 variant alters the human islet response to inflammatory and viral stress, reducing stress & death while preserving function https://t.co/2MLpWBo8d6

[Sek Kathiresan MD @skathire]

Nice sights 👌🏽

[ShorterLab @ShorterLab]

Protein expression is amplified by stabilizing mRNA using gene-specific antisense oligonucleotides: https://t.co/Qllj0anwEC

[Cell Chemical Biology @CellChemBiol]

GLP-1R and GIPR crosstalk modulates insulinotropic signaling pathways https://t.co/2HkJHLCsFt

[Anthropic @AnthropicAI]

Biologists use specialized open-source models for tasks like modeling the structure of molecular systems, designing drug-like molecules, and predicting the effects of genetic mutations. But these models are often expensive to run, potentially limiting their impact.

In our latest Science Blog, we share how Claude was able to optimize inference for more than 30 open-source models, making them 4x faster on average, partly by writing custom software for GPUs. We’re open sourcing all of the optimization code.

Read more: https://t.co/qiuN1jpgpA

[Cell Chemical Biology @CellChemBiol]

Mechanistic dissection of SMARCA2/4 molecular glues reveals programmable switching between DCAF16 and FBXO22 https://t.co/d7K4umPPWA

[Cell Chemical Biology @CellChemBiol]

Signaling of glycoRNAs to Siglec-11 protects neurons by suppressing NF-κB https://t.co/EoY2hJnFUX

[Cell Chemical Biology @CellChemBiol]

Dual-function PROTAC suppresses ferroptosis and restores neuronal function via brain-targeted delivery https://t.co/2NFuy0VJJB

[ShorterLab @ShorterLab]

Quality control of glycogen through direct ubiquitylation by RNF213: https://t.co/KaQUE5EVaG

[Josh Sommer @sommerjo]

Exciting moment in our long running quest to drug chordoma’s defining feature and key vulnerability brachyury, and great outcome of our drug discovery competition, the TBXT challenge. For the first time the main barrier to developing drugs that eliminate brachyury from cells has been overcome with the discovery of a compound that binds potently to the brachyury protein. Lots of possibilities now unlocked, and lots of work ahead to bring them to fruition. Very grateful to everyone who helped us over many years to reach this critical milestone.

[Kevin A. Scott, PhD @Sculpturatus]

multiplexed MS platform for molecular glue discovery immobilizes E3 ligases and identifies neosubstrates

https://t.co/1G9EOBW7iE

[David M. Sabatini @DMSabatini]

Very careful and interesting dissection of the roles of insulin/glucose vs amino acids in the activation of mTORC1 in the liver in response to feeding.
https://t.co/vop1XbBRbe