Jason C Kwan

Associate Professor of Drug Discovery at the University of Wisconsin-Madison studying marine natural products, biosynthesis and metagenomics. He/him

[Jason C Kwan @kwan_lab]

Just voted in my first presidential election since becoming a US citizen! FYI if you are in Wisconsin you can vote early from today.

[Jason C Kwan @kwan_lab]

7/7 Our interactive BGC atlas is now online (https://t.co/F4jojUPJ7e), featuring searches of >27,000 genomes associated with strains available from culture collections. Explore similar BGCs to each of the 2,502 BGCs in MIBiG! 🌐🔎 #GenomeMining #DrugDiscovery

[Jason C Kwan @kwan_lab]

6/7 We've precomputed SocialGene databases of various sizes based on RefSeq, including one with over 2 million antiSMASH 7.0 predicted BGCs - one of the largest public BGC compendia to date! 📚🦠

[Jason C Kwan @kwan_lab]

5/7 SocialGene is free, open-source, MIT-licensed, and designed for adaptability and extension. Check it out at https://t.co/wngTchueg3 🖥️🔓

[Jason C Kwan @kwan_lab]

2/7 We introduce SocialGene, a comprehensive software suite designed to collect, analyze, and organize multi-omics data into structured knowledge graphs. It can handle projects from small-scale to repository-scale analyses. 🧮📊

[Jason C Kwan @kwan_lab]

4/7 Key applications include targeted genome mining for drug discovery, accelerated searches for similar and distantly related biosynthetic gene clusters, and integration of chemical and analytical data. 💊🔬

[Jason C Kwan @kwan_lab]

3/7 SocialGene streamlines data ingestion, manipulation, aggregation, and analysis using Python and Nextflow libraries, culminating in a custom Neo4j database. It facilitates genomic synteny exploration and integrates diverse datasets. 🐍🔗

[Jason C Kwan @kwan_lab]

1/7 Excited to announce our new preprint on bioRxiv showcasing @ChasingMicrobes' SocialGene: https://t.co/j7TEHQNgZm

[Jason C Kwan @kwan_lab]

Muthusubramanian Venkateshwaran and Christopher Baker from @uwplatteville and Yari Johnson from the US Army Corps of Engineers.

[Jason C Kwan @kwan_lab]

Excited to share our latest study on the traits controlling soil bacterial community reconstruction after prescribed burns! 🔥🦠 Check it out on BioRxiv: https://t.co/FkqUKUJBBR #Microbiome #SoilHealth #PrescribedBurns

[Jason C Kwan @kwan_lab]

Big thanks to my co-authors and everyone who contributed to this research. 👏🎉 #TeamScience #ResearchCommunity @SiddUppal @JamieWoolet @TheaWhitman, Ashley Tung and Charlie Yu from @MemVerge as well as ...

[Jason C Kwan @kwan_lab]

After calling all the pharmacies I could think of this morning. Was told by one pharmacist that quartz do not consider it a nationwide shortage so aren’t granting exemptions. @UWMadison I don’t think you are getting good value for money with this plan which wastes worker’s time.

[Jason C Kwan @kwan_lab]

Big thanks to @QuartzBenefits for forcing me to switch to a different insulin, which is now almost impossible to get hold of presumably because lots of other people were also switched. Eventually found one vial in an out of network pharmacy…

[Tim Fallon, PhD @photocyte]

Is everything bigger in #Texas?? Me & @BradMoore_SIO are stoked to unveil the “PKZILLAs”: Genes for the new largest known enzymes and proteins in #biology, from the Texan fish-killing alga Prymnesium parvum. PKZILLAs make their giant 90-carbon polyketide toxin, prymnesin! 🧵1/n