Kwanho Kim

Associate Computational Biologist at the Broad Institute of MIT and Harvard

[Kwanho Kim @kwanho_k]

1/ How do structural variants regulate gene expression across brain cell types in Parkinson's disease? We are pleased to share our preprint suggesting large SVs exert potent regulatory effects both in specific cell types and shared across multiple cell types.
#ParkinsonsDisease

[Kwanho Kim @kwanho_k]

6/ A huge thank you to all my co-authors and collaborators who made this work possible, including @jzlevin , @seankenneths, ASAP Team Scherzer and Broad Institute!

[Kwanho Kim @kwanho_k]

1/ How do structural variants regulate gene expression across brain cell types in Parkinson's disease? We are pleased to share our preprint suggesting large SVs exert potent regulatory effects both in specific cell types and shared across multiple cell types.
#ParkinsonsDisease

[Kwanho Kim @kwanho_k]

5/ While cohort size restricts our statistical power to evaluate rare SVs, we hope this framework demonstrates the value of uniting long-read sequencing with single-cell transcriptomics. We welcome your feedback!

[Sean Simmons @seankenneths]

Excited to see this out after so many years! A big team effort to help understand allele-specific expression (ASE) in single-nucleus RNA-seq data, both from the experimental and computational sides. Thread: 1/n

[Arlotta Lab @ArlottaLab]

Thrilled to announce the latest @Arlottalab publication @Nature, led by @jeff_stogsdill and @Kwanhoya415. Congrats to the autors and to our collaborators Joshua Levin and Sami Farhi @broadInstitute. https://t.co/3zD1QqH5Xv