Ravi Bandaru

jeff med. i love plants and birds

[Journal of Clinical Investigation @jclinicalinvest]

@kyunkiwhynot @TMWiseDraper @yapingliu @NUFeinbergMed Behind the scenes: Cell-free DNA extraction by research associate Hailu Fu and computational analysis of cfDNA fragmentation led by first author Ravi Bandaru, a medical student.

[Journal of Clinical Investigation @jclinicalinvest]

@kyunkiwhynot @TMWiseDraper @yapingliu @NUFeinbergMed Genome-wide variation in cell-free DNA end motif entropy predicts immunotherapy response in head and neck cancer: https://t.co/RAHTOun7N5

[Journal of Clinical Investigation @jclinicalinvest]

A simple blood test may help predict which patients with head and neck cancer will benefit from immunotherapy: https://t.co/8zivPqkFaL

Ravi Bandaru @kyunkiwhynot Trisha Wise Draper @TMWiseDraper Yaping Liu @yapingliu & team @NUFeinbergMed develop a liquid biopsy that tracks fragmentation patterns of cell-free DNA across distinct genomic regions, representing a biologically meaningful, clinically actionable biomarker for the immunotherapy response in HNSCC.

The figure: cfDNA rMDS-based model predicts clinical outcomes in patients with HNSCC treated with pembrolizumab.
#HNSCC

[Shilatifard Lab @ShilatifardLab]

Congratulations to my colleague Dr. Yapig Liu @yapingliu for developing rMDS a cfDNA fragmentomics biomarker from whole-genome sequencing data that can predict response to perioperative pembrolizumab. This method outperformed PD-L1, tumor fraction, and other fragmentomic metrics and identified patients with improved disease-free survival. #HNSCC #LiquidBiopsy #CancerResearch @NU_BMG_SQE @NUFeinbergMed @NorthwesternU @jclinicalinvest https://t.co/jsurmCXD1J

[Northwestern Feinberg School of Medicine @NUFeinbergMed]

A Northwestern study suggests that a simple #BloodTest could help identify which patients with head and neck cancer are most likely to benefit from #Immunotherapy, per @jclinicalinvest. https://t.co/bLae8qPO5W

[Yaping Liu @yapingliu]

Thank you @GenomeWeb for covering our study: the variations of cfDNA end motif patterns may help predict immunotherapy response in head and neck cancer. https://t.co/w4lrfYX6yl
@NU_BMG_SQE
@NUFeinbergMed @jclinicalinvest

[Ravi Bandaru @kyunkiwhynot]

Very happy to share my first first-author paper in JCI. We show that cfDNA end motif entropy patterns can predict immunotherapy response in HNSCC.

Deeply grateful for @yapingliu and @TMWiseDraper for their years of mentorship and support. 🎉☺️

[Yaping Liu @yapingliu]

Our paper is out at JCI https://t.co/DM42jcqMKV. We found that the variations of cell-free DNA end motif entropy across genomic regions predict immunotherapy response in head and neck cancer. Great collaboration with @TMWiseDraper. Congrats to @kyunkiwhynot

[Waggoner Lab @LabWaggoner]

@medrxivpreprint Genome-Wide Variations of End Motif in Cell-Free DNA Fragments Distinguish Immunotherapy Responders from Non-Responders in Head and Neck Cancer @UCincyMedicine @CincyResearch @NorthwesternU @TMWiseDraper @Hildy46 @yapingliu

[Yaping Liu @yapingliu]

Our newest preprint for the pilot study of cell-free DNA methylation as the biomarker for multiple sclerosis to simultaneously classify MS subtypes, evaluate disability severity, and predict long-term progression. Collaboration work with
@phytoclover and Dr. Zongqi Xia!

[Yaping Liu @yapingliu]

Congratulations to my excellent trainee @r_bandaru_ who just received the runner up award from Science Olympiad Alumni Research (SOAR) foundation for the research work performed in my lab!!@NU_BMG_SQE https://t.co/oWQnmaAyVw

[Ravi Bandaru @kyunkiwhynot]

@yapingliu @HamesLee124 @NU_BMG_SQE Woohoo!

[Yaping Liu @yapingliu]

Want to extract fragmentation features from cfDNA WGS? Found existing code not runnable or not scalable to large dataset? Try our Finaletoolkit: extract more than ten different fragmentation features from a 100X WGS dataset (1 billion fragments) in 1.2 hours with multiple CPUs!