Yaping Liu

Assistant Professor in epigenomics and liquid biopsy, Northwestern University-Feinberg School of Medicine. Husband and a father of two kids.

[Journal of Clinical Investigation @jclinicalinvest]

@kyunkiwhynot @TMWiseDraper @yapingliu @NUFeinbergMed Genome-wide variation in cell-free DNA end motif entropy predicts immunotherapy response in head and neck cancer: https://t.co/RAHTOun7N5

[Journal of Clinical Investigation @jclinicalinvest]

@kyunkiwhynot @TMWiseDraper @yapingliu @NUFeinbergMed Behind the scenes: Cell-free DNA extraction by research associate Hailu Fu and computational analysis of cfDNA fragmentation led by first author Ravi Bandaru, a medical student.

[Shilatifard Lab @ShilatifardLab]

Congratulations to my colleague Dr. Yapig Liu @yapingliu for developing rMDS a cfDNA fragmentomics biomarker from whole-genome sequencing data that can predict response to perioperative pembrolizumab. This method outperformed PD-L1, tumor fraction, and other fragmentomic metrics and identified patients with improved disease-free survival. #HNSCC #LiquidBiopsy #CancerResearch @NU_BMG_SQE @NUFeinbergMed @NorthwesternU @jclinicalinvest https://t.co/jsurmCXD1J

[Lurie Cancer Center @LurieCancer]

A new @NorthwesternMed study suggests that a simple blood test could help identify which patients with head and neck cancer will be most likely to benefit from #immunotherapy, according to a study published in @jclininvest.

The advancement could help spare patients from ineffective treatment, said Yaping Liu, PhD (@yapingliu), who was senior author of the study. Read more: https://t.co/aSGxd11XeI

[Yaping Liu @yapingliu]

Thanks for the report to our recent cfDNA work! @NU_BMG_SQE
@NUFeinbergMed https://t.co/e4S3LstE3s

[Yaping Liu @yapingliu]

Thank you @GenomeWeb for covering our study: the variations of cfDNA end motif patterns may help predict immunotherapy response in head and neck cancer. https://t.co/w4lrfYX6yl
@NU_BMG_SQE
@NUFeinbergMed @jclinicalinvest

[Yaping Liu @yapingliu]

@mingxiangteng @TMWiseDraper @kyunkiwhynot Thank for your help to the project!

[Yaping Liu @yapingliu]

Our paper is out at JCI https://t.co/DM42jcqMKV. We found that the variations of cell-free DNA end motif entropy across genomic regions predict immunotherapy response in head and neck cancer. Great collaboration with @TMWiseDraper. Congrats to @kyunkiwhynot

[Waggoner Lab @LabWaggoner]

@medrxivpreprint Genome-Wide Variations of End Motif in Cell-Free DNA Fragments Distinguish Immunotherapy Responders from Non-Responders in Head and Neck Cancer @UCincyMedicine @CincyResearch @NorthwesternU @TMWiseDraper @Hildy46 @yapingliu

[Stephen Turner 🦋 @stephenturner.us @strnr]

New NIH Highlighted Topic: Technology Development for Genomics https://t.co/epnxN4PJ6D

[Northwestern BMG and SQE @NU_BMG_SQE]

Join us today for the BMG Seminar Speaker Dr. Viktor Adalsteinsson! Hosted by Dr. Yaping Liu @yapingliu #epigenetics #TumorDNA #DNA @NUFeinbergMed @NorthwesternMed @broadinstitute

[Ruslan Rust @rust_ruslan]

PlotGDP: an AI Agent for Bioinformatics Plotting

https://t.co/qHwasBWiVf

[Denis Wirtz @deniswirtz]

Federal funding for US biomedical research is moribund.

Since October 1 2025, NIH is -80% in new grants and -70% in values (total dollars).

Labs are closing down and researchers are leaving science.

To what end?

[Denis Wirtz @deniswirtz]

NIH is not issuing awards. You may think that it's because they it is coming up with new directions of research...The apposite is true.

Here is a graph showing how many fewer new funding opportunities that NIH has posted over time.

-91%, a trend that started on Jan 2025.

[Peter W. Laird (@peterwlaird.bsky.social) @peterwlaird]

Our paper on deep single-cell DNA methylation analysis is out in Nature Communications https://t.co/jpwk36NbR3. Super elegant work by Nathan Spix describing replication dynamics, X-inactivation, and cell lineage identification.

[Ajay Labade @ajaylabade31]

Thrilled to announce that our work on Expansion In Situ Genome Sequencing (ExIGS) is now published in @ScienceMagazine!
ExIGS allows us to sequence DNA and image proteins with super-resolution directly within single cells.
https://t.co/CEIsZdFrPU

[Jian Ma @jmuiuc]

We introduce EYKTHYR, a computational method that integrates gene expression and chromatin accessibility in a spatially aware model to identify transcription factors shaping spatial gene programs. Led by Lane Fellow @SpencerKrieger #spatialtranscriptomics https://t.co/rzLEgaBh4S

[Michael 英泉 Eisen @mbeisen]

The vast majority over discoveries are low hanging fruit when they are made. The key to scientific progress is progressively making more fruit low-hanging. One of the deep problems we have in science is that we reward the people who pick the fruit rather than the ones who lower the branches.

[Yaping Liu @yapingliu]

@lenghan_bioinfo @aimbe @IUIndianapolis @IUCancerCenter Congratulations!

[Yaping Liu @yapingliu]

@yuefeng_1 @aimbe @NU_BMG_SQE @NUFeinbergMed Congratulations!!