The Ito Lab

for Translational Tumor Immunology, Cancer Immunotherapy and Stem Cell/Developmental Biology Research at USC

[The Ito Lab @lab_ito]

A privilege to welcome Dr. Jennifer Wargo (@JenWargoMD) to @USCNorrisCC for Grand Rounds today. Dr. Wargo's pioneering work on the microbiome and immunotherapy has transformed the field and influenced how we treat patients. Thank you for an outstanding presentation and discussion

[The Ito Lab @lab_ito]

My lab members and I had a wonderful time at the ImmunologyLA Conference today. Congratulations to Hisashi and Steve for their outstanding presentations. A special congratulations to Steve for receiving the Young Investigator Award, sponsored by AAI. Well deserved!

[The Ito Lab @lab_ito]

Harnessing the Immune System In Situ: A Novel Approach to Broad-Spectrum Tumor Immunotherapy  https://t.co/RvrSzVNZfV
I appreciate my colleagues in medical/radiation/surgical oncology, staff at Norris, and patients and family members who have participated in this clinical study.

[The Ito Lab @lab_ito]

Great to see my lab members, Steven Luong, Joshua Ni and Dr. Hisashi Kanemaru presenting at #AACRIO26! @uscnorris @KeckMedicineUSC @KeckSchool_USC

[The Ito Lab @lab_ito]

We are happy to announce that Flow Cytometry and Immune Monitoring Core @uscnorris installed a cell sorter, Cytek Aurora CS, and will starting an assisted-sorting service from this week. Huge thanks to the support of Norris Foundation. We will have a seminar tomorrow (in-person).

[Cancer Research Communications @CRC_AACR]

#ICYMI: Impact of #Glucocorticoids on #ImmuneCheckpointInhibitor Efficacy and Circulating Biomarkers in #NonSmallCellLungCancer Patients https://t.co/f9AqLp61Yu
@lab_ito @md_hsu @nievamd @uscnorris @RoswellPark #NSCLC #OpenAccess

[The Ito Lab @lab_ito]

It is great to see that our article was selected in the Editors’ Picks from the August issues of the AACR’s 10 peer-reviewed journals. Thank you very much! @AACR @CRC_AACR

[Cancer Research Communications @CRC_AACR]

Check out this month's Editors' Pick:

Impact of Glucocorticoids on Immune Checkpoint Inhibitor Efficacy and Circulating Biomarkers in Non–Small Cell Lung Cancer Patients https://t.co/LTuW0rbrnE

[Keck Medicine of USC @KeckMedicineUSC]

Did you know the 💉 steroids used to ease cancer symptoms might interfere with immunotherapy?

A new Keck Medicine study shows that high-dose corticosteroids may block cancer-fighting T-cells — making treatment less effective for some lung cancer patients.

Dive into the research: https://t.co/cPSyGhho1u
#CancerResearch

[The Ito Lab @lab_ito]

Our newest article just came out @CRC_AACR! Congratulations on outstanding medical students, Lauren Polyakov and Angelina Lim for your excellent work showing the impact of steroids on ICI therapy and circulating biomarkers in NSCLC patients.

[Keck School of Medicine of USC @KECKSchool_USC]

Steroids Linked to Immunotherapy Failure

New research from @KeckMedicineUSC reveals that corticosteroids, often used to ease cancer-related symptoms in non-small cell lung cancer patients, may reduce the effectiveness of certain immunotherapies.
https://t.co/dgAOHsdAyi

[The Ito Lab @lab_ito]

Very proud of my former trainee, Dr. Kajihara presenting his work at the #AAI2025! In collaboration with ⁦@MarkLong_PhD⁩ and colleagues at Roswell Park, we looked at the evolution of genomic signatures in circulating TIL-TCR clones in a patient treated with ICI therapy.

[The Ito Lab @lab_ito]

Congratulations to Angelina Lim and Lexi Meyer on their first poster presentations at #AACR2025 !!

So proud of all ⁦@uscnorris⁩ ⁦@KeckMedicineUSC⁩ trainees for their outstanding work and collaborative spirit.

[OncoDaily @oncodaily]

@jitcancer @MarkLong_PhD @dkmlv1 @lab_ito We would like to inform you that your post has been published on https://t.co/igx4msE1Ge. Thank you for sharing such valuable content.
https://t.co/BoWKotejw8

[Journal for ImmunoTherapy of Cancer @jitcancer]

New #JITC short report: Divergent transcriptional states and kinetics of circulating tumor-infiltrating lymphocyte repertoires with highly homologous T-cell receptor sequences in a patient during immunotherapy https://t.co/p7uihdWuf5 @MarkLong_PhD @dkmlv1 @lab_ito

[The Ito Lab @lab_ito]

New publication from the Ito lab @uscnorris ! Circulating TIL-TCRs with highly homologous TCR sequences may respond differently to immunotherapy, and show distinct transcriptional signatures that are uniquely distinguished by the expression of GZMK. https://t.co/mRlCkn8Uzu

[The Ito Lab @lab_ito]

I'm pleased to share our new study published in Cancer Research Communications. I appreciate the hard work by Drs. Ishigaki, Yamauchi, Long, Hoki, Yamamoto and Oba.

[Cancer Research Communications @CRC_AACR]

Recently published:
Generation, transcriptomic states, and clinical relevance of CX3CR1+ CD8 T cells in #melanoma, by Hirohito Ishigaki et al.
https://t.co/CVjdhgadg2
#openaccess

[The Ito Lab @lab_ito]

I’m honored to serve as a director of the Flow Cytometry and Immune Monitoring Core and look forward to working with scientists and clinicians inside and outside of the USC.

[USC Norris Comprehensive Cancer Center @uscnorris]

Congrats to Dr. Fumito Ito who has been appointed as the new leader of the USC Norris Flow Cytometry and Immune Monitoring Core. Dr. Ito's experience and scientific expertise perfectly align with the responsibilities of this position.

[The Ito Lab @lab_ito]

I would like to congratulate Manali Begur, MS, a medical student @KECKSchool_USC on receiving an ASH Abstract Achievement Award #ash2023!  @USCStemCell @uscnorris

[The Ito Lab @lab_ito]

Ito lab member Lauren Polyakov presented her project evaluating the impact of steroids on anti-PD-1 therapy and T-cell differentiation in NSCLC patients. Lauren is an outstanding 1st year student and Saban Summer Research Fellowship recipient @KECKSchool_USC. #SITC2023 @uscnorris

[The Ito Lab @lab_ito]

We are actively #hiring a Technical Director of Flow Cytometry and Immune Monitoring Core at the USC Norris Comprehensive Cancer Center. Please let us know if you are interested!
Research Lab Manager https://t.co/l8Q9wgpyNy

[USC Norris Comprehensive Cancer Center @uscnorris]

Published in Cancer Research Communications, Dr. Fumito Ito and his team have identified a biomarker that indicates which patients with non-small cell lung cancer will respond well to chemoimmunotherapy. Read more about this discovery here:
https://t.co/NB7oFpIqKv