Mark Long

Assistant Professor of Oncology
Biostatistics & Bioinformatics
Roswell Park Comprehensive Cancer Center

[Journal for ImmunoTherapy of Cancer @jitcancer]

New #JITC short report: Divergent transcriptional states and kinetics of circulating tumor-infiltrating lymphocyte repertoires with highly homologous T-cell receptor sequences in a patient during immunotherapy https://t.co/p7uihdWuf5 @MarkLong_PhD @dkmlv1 @lab_ito

[Mark Long @MarkLong_PhD]

@brandoncor22 @EvanRantzaklis I accept any challengers

[Mark Long @MarkLong_PhD]

@HubertJeras We named the dog Indiana (Sean Connery voice)

[Mark Long @MarkLong_PhD]

@misterdooling @lab_ito 😆

[Mark Long @MarkLong_PhD]

Reporting another impactful study in collaboration with the fantastic @lab_ito. Using single-cell reference mapping we reveal the heterogeneity of iPSC derived DCs. Improving functional cDC generation from iPSCs could be a major boost for autologous DC based immunotherapy.

[Journal for ImmunoTherapy of Cancer @jitcancer]

New #JITC article: Generation of cDC-like cells from human induced pluripotent stem cells via Notch signaling https://t.co/BqPTEojnbn @lab_ito

[Mark Long @MarkLong_PhD]

I take solace in knowing deep down that the @BuffaloBills would have lost the super bowl on a last second 75 yard field goal that bounced off a defenders head in the end zone anyways.

[Adriana D. Benavides, Ph.D. - Cuz Immunology Rocks @Adri_CIR]

@CIR_AACR #OnlineFirst: Tumor-associated self-antigens show limited efficacy as therapeutic anticancer vaccines. A new method to systemically ID short CD8+ #Tcell #mimitopes that better inhibit tumor growth vs. the native epitope is presented. @MarkLong_PhD @jflovell 🧵🧵👇👇

[Mark Long @MarkLong_PhD]

@MorayCampbell @SmiragliaLab Shout out to the ever impressive @JacobiJustine for providing the final push to make this a reality. @CellReports

[Mark Long @MarkLong_PhD]

Proud of this one, contributions spanning my pre-doc, post-doc and junior faculty appointments, a true representation of my journey through this thing called academia. Bench, mouse, bioinformatics. Incredible mentorship from @MorayCampbell and @SmiragliaLab along the way.

[Cell Reports @CellReports]

Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer https://t.co/RjmV9UI8Ju

[Mark Long @MarkLong_PhD]

Product of a continuing collaboration with my postdoc mentor @SmiragliaLab (and remnants of my days at the bench!) linking DNA methylation dynamics in normal prostate epithelial cells to regions of aberrant hypermethylation in prostate cancer.

[Dominic Smiraglia @SmiragliaLab]

Read our latest #research on #DNAmethylation, published with @SpringerNature in @SciReports. Dynamic patterns of DNA methylation in the normal prostate epithelial differentiation program are targets of aberrant methylation in prostate cancer. https://t.co/xhle9TUdhR

[Stephen Turner 🦋 @stephenturner.us @strnr]

tidyseurat: Interfacing Seurat with the #Rstats tidyverse https://t.co/84TM9ZqpQ8
https://t.co/RAJwBGh6K5
https://t.co/jBK0co8tAm

[Yi Xing @YiXing77]

Our review on #RNA dysregulation as source of cancer #immunotherapy targets is out @TrendsinPharma! This work was supported by NCI @IOTNmoonshot @parkerici, with colleagues @CHOP_Research @UCLAstemcell @RoswellPark. Cover art by @robwang_916 of @UPennGCB! https://t.co/tHdaMDxvCx

[Mark Long @MarkLong_PhD]

I was falling asleep at orientation when @MorayCampbell walked in and asked if anyone wanted to go to @uni_lu and @VUamsterdam to study something called 'systems biology'. Truly a life changing experience, I could not have imagined where #CanSys and @RoswellPark would take me!

[Mark Long @MarkLong_PhD]

Wonderful study led by Shabnam Shalapour and Michael Karin, revealing epigenetic regulation of MHC-I AgPP augmented by low-dose chemotherapy. Honored to be a part of this exciting work, a collaboration fostered by @IOTNmoonshot. @RoswellPark @UCSDMedSchool
https://t.co/IF3dZ8RBSS

[Mara Averick @dataandme]

🤣 Wait for it...
TT @bri_xu https://t.co/FXAfpwBOPz #datascience ht @kierisi

[Rahul Satija @satijalab]

As part of @_hubmap we're excited to release a web app to automatically map scRNA-seq datasets to four organs, with more to come!

Just upload a gene expression matrix and hit 'Map cells to reference'

Check it out, run a demo, and map your own datasets: https://t.co/6Cvnej2zaP

[Rahul Satija @satijalab]

Interested in single cell genomics but need help getting started? Check out my lab's Single Cell Genomics Day on March 26. Talks will feature recent exciting computational and experimental advances and will be livestreamed at https://t.co/zG98gkckMU. Please RT/spread the word!

[Devang Mehta 🌱👨🏽‍🔬🧬 @drdevangm]

As promised, here's the recording of @mbeisen's fantastic talk at @MolCellSys last week.

But here's the deal: you have to promise to watch this the next time you're deciding where to submit your paper, and whether you'll @biorxivpreprint it, okay?

https://t.co/ziagK5DZ7W

[David Gfeller @GfellerD]

Prediction of neo-epitope immunogenicity reveals TCR recognition determinants and provides insight into immunoediting: Cell Reports Medicine https://t.co/AFnhDbcorI

[Rahul Satija @satijalab]

Seurat v4 is now available on CRAN! V4 includes tools for single-cell analysis of multimodal, spatial, and pooled CRISPR screen datasets. We also have an updated website with new vignettes, improved docs, and tips for analyzing and integrating many cells: https://t.co/7BMGF7wtHn