The Moraga group studies cytokines and their central role in immune regulation. We combine protein engineering, structural biology & immunology in our research
Disease-associated variant in IL6ST gene encoding for gp130 led to increased flexibility including motion within the cytokine-binding core (IL-6 and IL-11) and increased distance between extracellular domains
https://t.co/nPepamjV5m
Excited to share our newest full collaboration with @BubeckLab. We provide structural insights that help explain how mutations in gp130 that do not disrupt cytokine binding cause signaling defects and immunodeficiencies in humans. https://t.co/EF0OrJcx76, @UoDCellSigImm
🚨2 Yr Postdoc Available🚨
Jointly supervised with @scienceadvocacy working on normal and pathological HSCs, cytokines, malignancy, clonal expansion. Come and join us at the newly-formed @CBR_UoY@YBRI_UoY
Apply here 👇👇👇https://t.co/5rVf8SYmmH
Pls retweet and DM!
Ever wonder why ancestral cytokine receptors, like Gp130, bind multiple JAKs, and whether the identity of the GP130-JAK complex instructs specific responses? Check our new work, in a full collaboration with the @PiehlerLab, for some answers
https://t.co/SvuaVihj0z
📜State-of-the-Art📜
Molecular and cellular factors determining the functional pleiotropy of cytokines
🖋️ By Alison McFarlane, Elizabeth Pohler and Ignacio Moraga from @dundeeuni
🔗 https://t.co/zW2BxM6b3x
#cytokinesignalling#endosomessignalling
Interested in interleukin-6 and how you can therapeutically block its pro-inflammatory activities? See our latest review, just published in @NatRevImmunol — great team work together with @Lab_Jenkins, Stefan Rose-John @kieluni and Jens Moll/Jürgen Scheller @HHU_de
@FranInesta ni sabia que habia esa conferencia, la primera noticia que tengo, a ver cuando me invitais? Salgo barato mi hermano esta en badajoz, asique no necesito alojamiento!
Join us for the ICIS-sponsored and organized session at Immunity 2023! Learn how both academic and industry members of ICIS are advancing our understanding of cytokine biology and developing future immunotherapeutics.
Going to AAI? Please join us for the ICIS Guest Symposium "Understanding and Modulating Cytokine Activity through Structural Knowledge" @DrJuanLMendoza Saturday, May 13; 10:15 AM – 12:15 PM Eastern Time in Room 102AB
https://t.co/bn6a2ZjVFI via @httpstwittercomCytokineSociety
NEW for 2023 on the @SciImmunology website is the dedicated CANCER IMMUNOLOGY block.
🔗➡️https://t.co/rpcxdGgLOz
Scroll down to it & check out 6 recent #cancerimmunology papers. More exciting new content is on the way to this space soon!
#Cancer
L’acidité des tumeurs nuit à l’efficacité des thérapies anticancéreuses, selon une nouvelle étude. Des résultats qui pourraient conduire à une nouvelle génération de traitements d’immunothérapie.
➡️https://t.co/59sFZaU3L7
SPOTLIGHT: After showing that tumor-derived lactic acid limited IL-2 signaling, STAT5 phosphorylation, and antitumor activity in the TME, @Inserm@at_Mitralab used directed evolution to identify a pH-selective IL-2 mutein that bound IL-2Rα with [...] 👉 https://t.co/qm9G2tiprU