Moraga Lab

The Moraga group studies cytokines and their central role in immune regulation. We combine protein engineering, structural biology & immunology in our research

[Moraga Lab @LabMoraga]

@Dushek Congrat! Really well deserved!

[Bubeck Lab @BubeckLab]

After a hard year, I’m glad to see this finally over the line. A real team effort from ⁦@YiboJin ⁦@scott_d_gardner⁩ ⁦@TomasVoisin and others from ⁦@LabMoraga. As always, amazing data collection support ⁦@eBIC_Diamond⁩ #cryoem ⁦ https://t.co/8N0xttuxec

[Waggoner Lab @LabWaggoner]

Disease-associated variant in IL6ST gene encoding for gp130 led to increased flexibility including motion within the cytokine-binding core (IL-6 and IL-11) and increased distance between extracellular domains
https://t.co/nPepamjV5m

[Moraga Lab @LabMoraga]

Excited to share our newest full collaboration with @BubeckLab. We provide structural insights that help explain how mutations in gp130 that do not disrupt cytokine binding cause signaling defects and immunodeficiencies in humans. https://t.co/EF0OrJcx76, @UoDCellSigImm

[ICIS 🦋 @cytokinesociety.bsky.social @CytokineSociety]

#Cytokines2023 Metabollix and friends, thanks so much @laoneill111

[Moraga Lab @LabMoraga]

@BubeckLab @CR_UK @ERC_Research @wellcometrust @ImperialSci @imperialcollege Congrats! Great news!

[Hitchcock Lab @hitchcock_lab]

🚨2 Yr Postdoc Available🚨
Jointly supervised with @scienceadvocacy working on normal and pathological HSCs, cytokines, malignancy, clonal expansion. Come and join us at the newly-formed @CBR_UoY @YBRI_UoY
Apply here 👇👇👇https://t.co/5rVf8SYmmH
Pls retweet and DM!

[bioRxiv @biorxivpreprint]

Differential functional coupling in Gp130-JAK complexes expands the plasticity of the interleukin-6 signaling axis https://t.co/uWuBLVt5Iu #bioRxiv

[Moraga Lab @LabMoraga]

Ever wonder why ancestral cytokine receptors, like Gp130, bind multiple JAKs, and whether the identity of the GP130-JAK complex instructs specific responses? Check our new work, in a full collaboration with the @PiehlerLab, for some answers
https://t.co/SvuaVihj0z

[The FEBS Journal @FEBSJournal]

📜State-of-the-Art📜

Molecular and cellular factors determining the functional pleiotropy of cytokines

🖋️ By Alison McFarlane, Elizabeth Pohler and Ignacio Moraga from @dundeeuni
🔗 https://t.co/zW2BxM6b3x
#cytokinesignalling #endosomessignalling

[Juan L. Mendoza @DrJuanLMendoza]

So excited for this session, I couldn’t sleep! Cytokines, engineering, structures, and therapies.

Not a session to miss!

10:15 AM-12:15 PM room 102AB

[Moraga Lab @LabMoraga]

@DrJuanLMendoza Congrats Sir! Really well deserved.

[C. Garbers @c_garbers]

Interested in interleukin-6 and how you can therapeutically block its pro-inflammatory activities? See our latest review, just published in @NatRevImmunol — great team work together with @Lab_Jenkins, Stefan Rose-John @kieluni and Jens Moll/Jürgen Scheller @HHU_de

[Moraga Lab @LabMoraga]

@FranInesta ni sabia que habia esa conferencia, la primera noticia que tengo, a ver cuando me invitais? Salgo barato mi hermano esta en badajoz, asique no necesito alojamiento!

[Juan L. Mendoza @DrJuanLMendoza]

Join us for the ICIS-sponsored and organized session at Immunity 2023! Learn how both academic and industry members of ICIS are advancing our understanding of cytokine biology and developing future immunotherapeutics.

[ICIS 🦋 @cytokinesociety.bsky.social @CytokineSociety]

Going to AAI? Please join us for the ICIS Guest Symposium "Understanding and Modulating Cytokine Activity through Structural Knowledge" @DrJuanLMendoza Saturday, May 13; 10:15 AM – 12:15 PM Eastern Time in Room 102AB
https://t.co/bn6a2ZjVFI via @httpstwittercomCytokineSociety

[Ifor Williams @IforRWilliams]

NEW for 2023 on the @SciImmunology website is the dedicated CANCER IMMUNOLOGY block.
🔗➡️https://t.co/rpcxdGgLOz
Scroll down to it & check out 6 recent #cancerimmunology papers. More exciting new content is on the way to this space soon!

[Inserm @Inserm]

#Cancer

L’acidité des tumeurs nuit à l’efficacité des thérapies anticancéreuses, selon une nouvelle étude. Des résultats qui pourraient conduire à une nouvelle génération de traitements d’immunothérapie.

➡️https://t.co/59sFZaU3L7

[ACIR @ACIR_org]

SPOTLIGHT: After showing that tumor-derived lactic acid limited IL-2 signaling, STAT5 phosphorylation, and antitumor activity in the TME, @Inserm @at_Mitralab used directed evolution to identify a pH-selective IL-2 mutein that bound IL-2Rα with [...] 👉 https://t.co/qm9G2tiprU