Xin Lai

A Systems Biologist with passion for research, photograph, and cook.

[Xin Lai @laixinking]

📢 Call for Papers!
Our new Research Topic "Scalable and Interpretable Visual Analytics for Big Data" is now open for submissions in Frontiers in Bioinformatcs! 🧬💻
🗓️ Deadline: Nov 7, 2026
🔗 Submit here: https://t.co/mb7ixX8jk6

#Bioinformatics #DataViz #BigData

[ISCB News @iscb]

🚨Paper submissions to iscbAI are due tomorrow, Monday, June 1!

📥 Submit here: https://t.co/ekGGuG8gCP

[Xin Lai @laixinking]

New research in @CMLS_Journal provides the first systematic look at SOX10-mediated miRNA regulation in Uveal Melanoma (UM).

🔗 Read the full study here: https://t.co/DNoOt8Rgav
#UvealMelanoma #CancerResearch #SystemsBiology #miRNA #Bioinformatics #Oncology #PrecisionMedicine

[Xin Lai @laixinking]

@acagamic Thanks so much for sharing your insights and experience.

[Xin Lai @laixinking]

The Biorxiv preprint is available at https://t.co/awg4BWsEBE

[Xin Lai @laixinking]

We develop #RingNet to visualize #multi-modal data in #networks. It is powerful to visualize your #cohort and #single-cell #omics data. All you need are the csv files for your data and networks, and RingNet can support svg, pdf output. Try it out at
https://t.co/CZ7dokBbbJ

[Xin Lai @laixinking]

The latest research from Guo's lab at @theNCI shows that one hotspot mutation in #DICER1's RNase IIIb can lead to loss and gain of function 5p-miRNA and the gain of function of 3p-miRNA.
https://t.co/EndMCsOqrA

[Xin Lai @laixinking]

See our new preprint, where we used a network biology method to identify novel therapeutic targets for uveal #melanoma.
#networkmedicine #bioinformatics #cancer

[bioRxiv Cancer Bio @biorxiv_cancer]

A computational SOX10 network-based selection strategy to identify new drug targets in uveal melanoma https://t.co/oITIFEb0tv #biorxiv_cancer

[Xin Lai @laixinking]

Seedless binding in #miRNAs can also lead to gene repression as shown with miR-155 and miR-124, though this unconventional binding accounts ~1% of miRNA binding. See Bartel lab's new paper for details.

Functional microRNA targeting without seed pairing https://t.co/TifY1q4DXQ

[Xin Lai @laixinking]

New preprint on IDH-mutant #astrocytomas: We analyzed rare patient samples showing grade 2-3→4 progression post-therapy. Key findings: #ncRNAs drive astrocyte dedifferentiation; tumor suppressor #miRNA let-7b-3p shows recurrent deletions; #lncRNA NEAT1 regulates ECM organization

[bioRxiv Cancer Bio @biorxiv_cancer]

Integrative multi-modal analysis reveals the contribution of noncoding RNAs to post-treatment progression of IDH-mutant astrocytomas https://t.co/oXUx6n16wF #biorxiv_cancer

[Xin Lai @laixinking]

Our commitment to open science means the HallmarkGraph data and code are publicly available on #GitHub and #Zenodo.
#OpenScience #FAIRdata #Research #GitHub #DataSharing
https://t.co/HALa3YT1L7
https://t.co/RPhvoL1iSi

[Xin Lai @laixinking]

New publication at #Bioinformatics of @OxfordJournals.
HallmarkGraph: a cancer hallmark informed graph neural network for classifying hierarchical tumor subtypes
#CancerResearch #MachineLearning #AIinMedicine #PrecisionOncology
https://t.co/DdYxziDHGl

[Xin Lai @laixinking]

We built HallmarkGraph to be transparent. By integrating gene-level features with cancer hallmarks, we can now provide clear explanations for our model's predictions. #InterpretableAI #ComputationalOncology #MedicalAI

[Xin Lai @laixinking]

The forum's emphasis on translating academic research into practical applications through industry partnerships reflects the urgent need for scalable, data-driven healthcare solutions that can be deployed globally to improve patient outcomes and population health management.

[Xin Lai @laixinking]

The 2nd China-Germany-Finland Life Sciences Forum, held at Tampere University, has successfully concluded. The forum brought together 60 researchers from five countries. The forum focused on AI in biomedical research and health data science innovation.
https://t.co/qo5NCww1pc

[Xin Lai @laixinking]

The second day's session on the digitization of health benefited greatly from the participation of high-level government officials and Chinese and Finnish companies, including @avaintec , @AtostekOy , SOENIA®, @NADMED_Ltd, 神州医疗.

[Journal of Experimental & Clinical Cancer Research @JournalofExper1]

Just published!🦠

Repurposed #clindamycin suppresses #pyroptosis in tumor-associated macrophages through Inhibition of caspase-1

Open access🔓
https://t.co/WbBrI3iASF

#DrugRepurposing
#TumorAssociatedMacrophages
#Immunotherapy
#UvealMelanoma