Laura Casares Perez

Cell Biologist at @UoDCeTPD

[Keith Hornberger @KRHornberger]

Important cautionary tale on how interrupting protein synthesis can generate false positive signals for degraders, which can’t always be teased out with common control experiments. Ends with some solid recommendations on the right way to fly.
https://t.co/Uhas1hhGTV

[Vesna Vetma @VesnaVetma]

So nice to see this paper out in its final form. Hope our learnings can help you identify and confirm true, on-target degraders!
Big thanks to the project team across both organisations @UoDCeTPD @Boehringer @alessiociulli

https://t.co/s5ehdxVcMN

[Women in TPD & Induced Proximity @WomenInTPD]

Excited to announce our upcoming free virtual Networking events on 16th of July, 2024 with special guests joining for a fireside chat! This is a great opportunity to hear from and interact with trailblazers in the field and then network in smaller groups. Links below to sign-up

[Amphista Therapeutics @AmphistaThera]

Today we have unveiled a new mechanism of action for the degradation of BRD9 that is completely differentiated from cereblon- or VHL-based PROTACs.

Read the full announcement here: https://t.co/pRZ6TmlnAu

#DrugDiscovery #Biotech #TargetedProteinDegradation #CeTPD #TPD

[Laura Casares Perez @Laura_C_95]

We didn’t find any degraders but we sure did learn a lot! Give this a read if you want to find out how to differentiate artefacts from genuine degraders 🧫

[Vesna Vetma @VesnaVetma]

I'm happy to share that our new manuscript in collaboration with Boehringer Ingelheim is now out.

1/ Whilst we didn't find any CRAF degraders, we report some key learnings on identifying artefactual degraders

@UoDCeTPD
@Boehringer

https://t.co/clw8PiB8Eo

[Alessio Ciulli @alessiociulli]

Excited to introduce CRBN-Midi: a construct engineered to accelerate biophysics and high-resolution crystallography of CRBN ligands and degraders design. A tour-de-force work at @UoDCeTPD by a fantastic team led by Alena Kroupova and David Zollman. 1/11 https://t.co/h7BSi9NfKO

[Laura Casares Perez @Laura_C_95]

@Marco_A_Calzado @ACorreasa @UoDCeTPD @UoDLifeSciences @alessiociulli @Univcordoba @IMIBIC Enhorabuena 🎉

[Vesna Vetma @VesnaVetma]

I'm very proud to share this one-
our panKRAS degrader is now out!

Thanks to the fantastic collaboration team from @UoDCeTPD and @Boehringer!

[Selección Española Femenina de Fútbol @SEFutbolFem]

⭐️ ¡¡𝗦𝗢𝗠𝗢𝗦 𝗖𝗔𝗠𝗣𝗘𝗢𝗡𝗔𝗦 𝗗𝗘𝗟 𝗠𝗨𝗡𝗗𝗢!!

🏆 ¡¡LO HEMOS LOGRADO!!

🥹 No sabéis lo que esto significa realmente.

🫶 ¡¡HISTORIA DEL FÚTBOL ESPAÑOL!!

Lᴏs sᴜᴇɴ̃ᴏs sᴇ ᴄᴜᴍᴘʟᴇɴ... ❤️

🆚 #ESP - #ENG I 1-0

#JugarLucharYGanar I #FIFAWWC I #CampeonasDelMundo

[Vesna Vetma @VesnaVetma]

We're hiring!
Join our cell biology team 🎉

[Women in TPD & Induced Proximity @WomenInTPD]

Thrilled to announce our first free virtual events with special guests Nicki Thompson @AmphistaThera & Paola Martinelli @Boehringer (Europe event), and Brenda Schulman @MPI_Biochem & Kat Kayser-Bricker @HaldaTx (US event). Registration links in comments below!

[Open Arms @openarms_fund]

Este es el equipo humano en la primera línea de la #misión100 del #OpenArms que hoy termina.
117 personas rescatadas y cientos auxiliadas en el #Med
Mientras haya una sola vida abandonada en este mar convertido en cementerio, seguiremos.
Hoy más que nunca, denunciamos la falta de humanidad y la inacción deliberada de las administraciones para rescatar a quienes se lanzan al mar ante la imposibilidad de hacerlo por #viaslegalesyseguras
Gracias, equipazo por vuestra entrega, compromiso y generosidad. Sois los brazos de una multitud personas que desde tierra lo hacen posible.
📸 @joanmateuparra

#openarms #duelouniversal #cadavidacuenta #life #humansbeinghumans

Ayúdanos a seguir. Te necesitamos
https://t.co/zaFKxSVK8E

[Laura Casares Perez @Laura_C_95]

@ritadorta @Ryanair Oh no! Hope you get there in time Rita 🤞🏼

[Women in TPD & Induced Proximity @WomenInTPD]

@Laura_C_95 presenting at #EACR2023 in Torino on learnings and development of CRAF degraders 👏👏👏 #CeTPD @dundeeuni #WomenInTPD

[Laura Casares Perez @Laura_C_95]

All ready for #EACR2023! Come by my poster tomorrow (EACR23-0066) if you want to find out all the ways your project might go wrong in Targeted Protein Degradation 🧪👩🏼‍🔬 @UoDCeTPD

[Laura Casares Perez @Laura_C_95]

@Valproito Felicidades Cañi 🎉

[Alessio Ciulli @alessiociulli]

Proud to join our @CeTPD_Dundee outreach team for its first public event showcasing our degrader activities! Thanks @dundeewomenfest @engageUoD @UoDLifeSciences for hosting us

[Danette Daniels @danetteldaniels]

Announcing today a new initiative for Women in TPD and Induced Proximity!!! This network will strengthen, recognize, and support female contributions and leadership in targeted protein degradation, induced proximity, and chemical biology. Join here!
https://t.co/A4ZiGhxGA6

[Laura Casares Perez @Laura_C_95]

Had a blast at the EC-TPD event yesterday! Massive thanks to all the panelist and organisers - it was a fantastic day 🧫

[Vesna Vetma @VesnaVetma]

Panelist discussion at EC-TPD

@alessiociulli @danetteldaniels @EndriuT @chiaramaniaci @val_spiteri and Mike Hann

@UoDLifeSciences #tpd