Laurits Frøssing

Specialist registrar #respmed and postdoc @respbispebjerg doing #translationalresearch.
Main interests are airway immunology and sputum methodology.

[Celeste Porsbjerg @CPorsbjerg]

Deligthed to see our paper out, demonstrating a universal role of mast cells in asthma - but with different localizations across asthma phenotypes. #asthma #phenotype #ahr. #mastcellsmatter https://t.co/sG1a4CcNyJ

[Laurits Frøssing @lauritsfrossing]

@doclip1 I agree that T2-low is where we lack options and assessment of Teze on strictly T2-low would be very enlightning albeit difficult to recruit to as you highlight. IMHO a key step is moving away from a definition based on the absence of T2 to the presence of something.

[Laurits Frøssing @lauritsfrossing]

@doclip1 We have been cautious with the terminology in both papers ie "no biomarkers elevated" rather than "T2-low" for this exact reason.

[Laurits Frøssing @lauritsfrossing]

@doclip1 I believe we agree on the prevalence of true T2-low - it is rare - and I do not believe the references Venn-diagram is fit to identify true T2-low as would lower cutoffs for both IgE and B-eos would be needed IMO.

[Laurits Frøssing @lauritsfrossing]

Happy to see our research highlighted by the ERS!
A key takeaway for daily practice is the need for routine airway inflammometry - not only in specialized SA clinics - as eosinophilia otherwise is overlooked in a large proportion of patients @RespBispebjerg @PluZdk @CPorsbjerg

[ERS publications @ERSpublications]

T2 inflammation is highly prevalent, with biomarker co-expression a particular trait of severe asthma. The best treatable trait, eosinophilia, is missed in half of patients with mild–moderate and one-third with severe asthma without airway inflammometry. https://t.co/XFUpMbC4bE

[Christian Wøhlk @CWhlk]

Extremely proud to share our first study coming out of the VITAL study: "Allergen Immunotherapy Enhances Airway Epithelial Antiviral Immunity in Patients with Allergic Asthma" https://t.co/JmK1hHnxWf #asthma #Immunology #Immunotherapy @RespBispebjerg

[Celeste Porsbjerg @CPorsbjerg]

Happy to see our Lancet seminar on asthma out!
https://t.co/PwFaO4S2Kj

[Jonas Egebart @JonasEgebart]

Vi bruger tid & kræfter i @akutberedskabet på at tage os af folk, der har drukket for meget - og faktisk kan du hjælpe! Se Karl fortælle om det her, og del meget gerne videoen. #sundpol #dkpol @RegionH

[Celeste Porsbjerg @CPorsbjerg]

Calling all translational researchers with an interest in airways immunology og strong team skills!
Excellent opportunity to be part of a truly clinical translational team - in a fantastic era of targeted immune treatments - with a strong focus on impact! https://t.co/xYaQZVYqd0

[Laurits Frøssing @lauritsfrossing]

@CPorsbjerg #bronchiectasis #severeasthma #eosinophilia

[Laurits Frøssing @lauritsfrossing]

Excited to share our recent findings highlighting airway eosinophilia - and in particular eosinophil degranulation - as a key player in severe asthma patients with bronchiectasis.
https://t.co/8lJjZRfxL1

[Laurits Frøssing @lauritsfrossing]

Exiciting times ahead with studies assessing treatments targeting both inhibiting of eosinophil degranulation (LTRA) and also IL5 (mepo -> Uni of Catania @Crimillina)
@RespBispebjerg @JACIGlobal @jacionline

[Celeste Porsbjerg @CPorsbjerg]

Time to consider allergen immunotherapy in asthma patients with frequent infection driven flare-ups? Exciting findings from @CWhlk @RespBispebjerg #diseasemodification #preventsevereasthma #asthma #allergy #infections #exacerbations

https://t.co/DIB5B9Fda7

[Laurits Frøssing @lauritsfrossing]

@katiejbaines Thank you Katie, hope everything is well with you. Time flies.

[Laurits Frøssing @lauritsfrossing]

In this real life cohort of asthma patients we compare expression of biomarkers - including induced sputum - across asthma severity. https://t.co/ONrAlaeYWu

[Laurits Frøssing @lauritsfrossing]

A huge thanks to all coauthors and collaborators for their huge contributions.
@RespBispebjerg @CPorsbjerg @PluZdk @ERSpublications

[Laurits Frøssing @lauritsfrossing]

We find T2 inflammation to be more prevalent in SA and that biomarker expression relating to more than one pathway to be a particular trait of SA.
Our findings also highlight the need for clinically feasible airway inflammometry as 22% of patients had airway eos without blood eos

[Pulmonology Advisor @PulmAdvisor]

In patients with severe asthma, former smoking history is associated with eosinophilic airway inflammation and activation, relative insensitivity to steroids, and airway autoimmunity. Study in @ERSpublications. #pulmonology @lauritsfrossing @DrMMukherjee

https://t.co/9cYwrce5JX