leadXpro

Structural Biology of Membrane Proteins

[leadXpro @leadxpro]

Our LptDE paper finally got published in Nature Communications, 13, 1826 (2022).
..
Here is the link to the article:
https://t.co/q1ykFQaeG8

A short blog story written for Nature:
https://t.co/3gjUgyLUOm

And the link to our previous news story:
https://t.co/posxzkf2Bm

[leadXpro @leadxpro]

How are progresses in #AI and #structuralbiology impacting drug discovery? Find out in our latest article where we highlight advancements in five fast-growing techniques:
https://t.co/U886j90KMk

[leadXpro @leadxpro]

Announcing new talk by Michael Hennig, CEO of leadXpro, at https://t.co/YqEq7kju7z

[leadXpro @leadxpro]

leadXpro has a new website! —> https://t.co/O7ovML7Vnc

Here you can explore our scientific developments, evolving pipeline and fantastic partnerships.

We want to take this opportunity to thank all of our supporters, who have contributed to our success over the last 6 years.

[leadXpro @leadxpro]

leadXpro reports the first structure of the human Kv3.1 channel, solved at 2.6 Å by cryo-EM, in the apo state and in complex with a ligand from our collaborators at Lundbeck. The structure of this important CNS drug target reveals a novel binding-site for positive modulators.

[leadXpro @leadxpro]

Binding partners are essential tools for structure research. leadXpro has patented “Pro-Macrobodies” or PMbs, novel proteins that fuse target-specific nanobodies with a maltose-binding protein via a rigid linker. The rigid linker was optimized using molecular dynamics simulations

[leadXpro @leadxpro]

The remarkable gymnastics of β-barrel outer membrane proteins.

The lateral opening of lipopolysaccharide (LPS) transporter LptD, as seen by cryoEM, hints at how LPS is released into the bacterial outer membrane.

Find out more at: https://t.co/IkUonqDWCG

[leadXpro @leadxpro]

leadXpro is happy to report the structure of LptDE - solved by cryo-EM at high resolution - which provides structural basis for the discovery of novel antibiotics targeting lipopolysaccharide (LPS) transport on the bacteria outer membrane. https://t.co/IkUonqDWCG

[leadXpro @leadxpro]

Dr. Michael Hennig, CEO at leadXpro, will be giving a webinar at Symeres, Thursday March 11th at 6 PM CET (9 AM PT).

Register here:
https://t.co/H1Ww78OLYt

[leadXpro @leadxpro]

We are hiring !!
https://t.co/gDb6kT2E8g

[leadXpro @leadxpro]

Today, leadXpro is celebrating it’s 5th anniversary! 🥳🎂🎉

A huge thank you to everyone who has supported the company, from start-up to industry leader. Thanks to this, we have produced more than 40 novel ligand-complexed X-ray and cryo-EM structures of membrane proteins.

[leadXpro @leadxpro]

Axxam S.p.A, leadXpro AG and MercachemSyncom announce a strategic alliance for world-class integrated structure-guided drug discovery services for membrane protein targets.
https://t.co/WN427rrdHK
#drugdiscovery #drugdevelopment #discovery #chemistry #biology #medchem

[leadXpro @leadxpro]

https://t.co/fGjKcsaDG3

[leadXpro @leadxpro]

First Cryo-EM structure of the agonist complexed human TRPV4 ion-channel in the open-conformation

[Peter Nollert @reducentropy]

2.6 Å structure multidrug & toxic comp extrusion transporter
could aid design of optim pharmacokinetic drug profiles
https://t.co/30CX5VnfcL
@nature

[Peter Nollert @reducentropy]

Light controlled membrane channel high res structures
#optogenetics workhorse channelrhodopsin 2
://goo.gl/FFsnwW https://t.co/DO52ykGBup

[Peter Nollert @reducentropy]

#cryoEM now with dynamics
Applied to membrane receptor protein
https://t.co/E0yl6Olj7B

[Peter Nollert @reducentropy]

The only way to improve protein structures: wwPDB OneDep
https://t.co/jWwJMh7p4x
Paper: https://t.co/ko4RwHW6vU

[Peter Nollert @reducentropy]

Relationship of receptor gymnastics with transmembrane signalling:
biological function arising from time & length domains
https://t.co/TS9ukdAdzn

[Peter Nollert @reducentropy]

Status of #GPCR modeling & ligand docking
https://t.co/H6fCsiO4rx