Looking for a Drug Discovery Data Architect to join Omeros (Seattle, WA). Would love talking to you - especially if you can cross over life science / data.
https://t.co/J9vOLSDAxn
Structural transitions along the catalytic cycle of the bacterial MurJ flippase visualized by molecular morphing (PDB codes: 6NC6, 6NC7, 6NC8 and 6NC9) #scivis#sciart#molecularart#UCSFChimeraX
Read my Feb 2 newsletter : “Transmembrane impacting drug molecules” https://t.co/a4hnARn1t1
Seeing signalling and transport clearly and with a little help from AlphaFold
Fortunately no further mutations in Mpro of PANGO lineages BA.2 & BA.3. All with same P3395H (ORF1a) mutation. Same (=none at all?) impact on #paxlovid effectiveness
Anybody seen enzyme inhibition data?
#Omicron mutation P132H in SARS-CoV-2 main protease (nsp5 = Mpro = 3CLpro) ~22Å away from active site but on same loop; expecting minimal impact on #Pfizer drug PF-07321332 (nirmatrelvir, #paxlovid active ingredient) inhibition; data?
#Omicron mutation P132H in SARS-CoV-2 main protease (nsp5 = Mpro = 3CLpro) ~22Å away from active site but on same loop; expecting minimal impact on #Pfizer drug PF-07321332 (nirmatrelvir, #paxlovid active ingredient) inhibition; data?
A Perspective on the new paper in @ScienceMagazine by @BShoichet and friends. Bottom line? There are no short cuts to finding effective anti-viral medicines for Covid. @HartungIngo
https://t.co/P4tmBKenVF