Peter Nollert

How do membrane proteins work? Enjoying protein structure/function stories, drug discovery and cutting edge bio-technologies.

[Peter Nollert @reducentropy]

Everything about lipids that you'd ever want to know. In-depth review
https://t.co/TB7RDIQFwT
@NatRevMCB

[Peter Nollert @reducentropy]

Was a nice run. Possibly last tweet
#MyTwitterAnniversary

[Peter Nollert @reducentropy]

Looking for a Drug Discovery Data Architect to join Omeros (Seattle, WA). Would love talking to you - especially if you can cross over life science / data.

https://t.co/J9vOLSDAxn

[Francisco J. Enguita @fenguita]

Structural transitions along the catalytic cycle of the bacterial MurJ flippase visualized by molecular morphing (PDB codes: 6NC6, 6NC7, 6NC8 and 6NC9) #scivis #sciart #molecularart #UCSFChimeraX

[Peter Nollert @reducentropy]

Read my April 25 newsletter: “cryoEM dominating membrane protein structural biology”
https://t.co/v0A7oe7XS7

[Peter Nollert @reducentropy]

Read my March 28 Newsletter : “Membrane proteins sculpting membranes and lipid droplets” https://t.co/RNlVsDXinx

[Peter Nollert @reducentropy]

Read my Feb 2 newsletter : “Transmembrane impacting drug molecules” https://t.co/a4hnARn1t1
Seeing signalling and transport clearly and with a little help from AlphaFold

[Peter Nollert @reducentropy]

Fortunately no further mutations in Mpro of PANGO lineages BA.2 & BA.3. All with same P3395H (ORF1a) mutation. Same (=none at all?) impact on #paxlovid effectiveness
Anybody seen enzyme inhibition data?

[Peter Nollert @reducentropy]

#Omicron mutation P132H in SARS-CoV-2 main protease (nsp5 = Mpro = 3CLpro) ~22Å away from active site but on same loop; expecting minimal impact on #Pfizer drug PF-07321332 (nirmatrelvir, #paxlovid active ingredient) inhibition; data?

[Peter Nollert @reducentropy]

Read my Jan 10 newsletter “From 3D structure to new drugs” https://t.co/Up2GhX4S2S

[Peter Nollert @reducentropy]

Viruses make odd #MembraneProteins
#HepatitisC
https://t.co/pURdJYDDEN

[Peter Nollert @reducentropy]

#Omicron mutation P132H in SARS-CoV-2 main protease (nsp5 = Mpro = 3CLpro) ~22Å away from active site but on same loop; expecting minimal impact on #Pfizer drug PF-07321332 (nirmatrelvir, #paxlovid active ingredient) inhibition; data?

[Peter Nollert @reducentropy]

Read my Nov 8 newsletter
“The secret lives of membrane proteins — as never seen before”
https://t.co/5Nrj5cBMkk

[Peter Nollert @reducentropy]

@demishassabis @IsomorphicLabs Like your vision. Good luck finding the fit and niche for your technology

[Peter Nollert @reducentropy]

Read my Nov 1st newsletter: “Unleashing the power of AI & video gaming on membrane protein structures” https://t.co/n2nWSZV8uj

[Peter Nollert @reducentropy]

Read my Oct 11 newsletter: “The assembly makes the function” https://t.co/jHOfsBx3xT

[Peter Nollert @reducentropy]

Ready my 20 Sept newsletter: "Membrane protein structures key to new drugs” https://t.co/ctqiaNKF31

[Peter Nollert @reducentropy]

Read my 13 Sept membrane protein/SBDD newsletter "Everything seems connected"
https://t.co/327MaLAe5R

[Peter Nollert @reducentropy]

How often should I send out a membrane protein / SBDD newsletter?

[Peter Nollert @reducentropy]

Read my 30 August membrane protein/SBDD newsletter:

Membrane protein structures bearing more membrane protein structures

https://t.co/G7ByN20o1D

[Peter Nollert @reducentropy]

Read my 16 August membrane protein/SBDD newsletter:

"Lipids getting in and out of the way"

https://t.co/nmHKgMIbt6

[aled edwards @aledmedwards]

A Perspective on the new paper in @ScienceMagazine by @BShoichet and friends. Bottom line? There are no short cuts to finding effective anti-viral medicines for Covid. @HartungIngo

https://t.co/P4tmBKenVF