Leonardino (Dino) Digma

PGY-2, neurology, neuroscience, imaging, cognition, neurodegenerative diseases 🧠

[Bruce Goldman @brucegoldman]

A #Stanford_Medicine neurologist explains why a trio of closely related drugs all aimed at treating #Alzheimers_disease -- while so promising in theory --don’t appear to be helping patients much if at all. #plaque_attack_fail

https://t.co/O4Bs2k78AJ

[Leonardino (Dino) Digma @leonardinosaur]

Thank you @brucegoldman for highlighting and nicely summarizing our recent commentary on the limitations of recent anti-amyloid trials.

https://t.co/sVfxJ3UbQm

[Gaurav Chattree @GChattree]

If you’re at #ADPD2024 and curious about how Amantadine works in PD, please stop by either today or tomorrow at poster 454. Great meeting so far in Lisbon!

[Jeffrey Dunn MD @JeffreyDunnMD]

Dr. Cory Dodson @cocodods @Stanford_Neuro presents infection risk of CD20+ therapy @ACTRIMS

[Leonardino (Dino) Digma @leonardinosaur]

Another month of wards in the books! Feeling grateful to have gotten to work with the best senior (@EmilyLChu) best co-intern (@XC_Cortez) and best med student (@MedMusicMel) @StanfordMedRes

[Seb Walsh @seb_walsh]

Great piece in @journal_ad from @leonardinosaur @joe__winer and Michael Greicius from Stanford on functional unblinding, amyloid removal as a surrogate, and data transparency.

Substantial Doubt Remains about the Efficacy of Anti-Amyloid Antibodies
https://t.co/QCuhiFwbVW

[Leonardino (Dino) Digma @leonardinosaur]

Our commentary on some of the yet unaddressed limitations of the recent anti-amyloid therapies/trials is now out in @journal_ad !! #EndAlz #Alzheimers #ADRD #amyloid #tau #HAI2024

https://t.co/95asY3wjIO

[Leonardino (Dino) Digma @leonardinosaur]

S/p ten (10) day stretch to cap off another month on the @StanfordMedRes wards. Tough to be away from friends/fam over the holidays, but ‘twas nice working with and getting to know my future @Stanford_Neuro co-res Akshara!

[Vahan Aslanyan @VahanAslanyan]

My newest project with @PaLab_UCSD exploring the role of cerebrovascular reactivity in developing mild cognitive impairment is now out in @alzdemjournals!🧠https://t.co/H5RBSGGhfu

[Michael Belloy @BelloyMichael]

An interesting and relevant piece worth reading, by my postdoc mentor Mike Greicius: "Substantial Doubt Remains about the Efficacy of Anti-Amyloid Antibodies"

https://t.co/YNzmdJqKHB

[Lia Talozzi @lia_talozzi]

Is it possible to cure #AlzheimersDisease? The press has been so enthusiastic about anti-amyloid antibodies, but are they really improving patients? In this @arxiv lead by my P.I. Michael Greicius, some doubts still remain. 👉 https://t.co/EZ50Yw9p7R @StanfordMed @Stanford_Neuro

[Joe Winer @joe__winer]

Check out Dino's (@leonardinosaur) excellent and important new piece on anti-amyloid therapies, written with Mike Greicius

[Jake Vogel @_JakeVogel_]

Wow! Some very contentious statements therein. Worth a read!

[Leonardino (Dino) Digma @leonardinosaur]

#EndAlz #ClinicalTrials #AlzheimersDisease #Amyloid @CTADconference @KarlHerrup @LonSchneiderMD @DavidJonesBrain

[Leonardino (Dino) Digma @leonardinosaur]

With #CTAD23 happening, it is an exciting week for the AD field. To contribute to the discussion, we (I, @joe__winer, and Mike Greicius) wanted to highlight three observations regarding recent anti-amyloid clinical trials:

https://t.co/2yNv4UZ9PJ

[Leonardino (Dino) Digma @leonardinosaur]

@alleolabs @VahanAslanyan Not sure! Although I think there is a process for requesting data from ADCS trials that might be helpful https://t.co/ySwNXDwcwG

[Leonardino (Dino) Digma @leonardinosaur]

Sad that I can’t be in Amsterdam for #AAIC23 but excited to share our work as a virtual poster for the conference. This project involved a post-hoc analysis of the EXERT trial, looking at the association between amount of exercise completed and regional brain atrophy.

[Leonardino (Dino) Digma @leonardinosaur]

@alleolabs @VahanAslanyan Sorry for the delay in replying here. For our analyses, we averaged across L and R hippocampus, b/c I did not feel there was strong aprior reason that exercise would associate with just the L or just the R side. Although we can certainly look into it.

[Leonardino (Dino) Digma @leonardinosaur]

S/o to @VahanAslanyan @PaLab_UCSD @ADCSResearch and other mentors for supporting this work.

[Leonardino (Dino) Digma @leonardinosaur]

Looking forward to digging into these associations further. Feel free to reach out if you have any questions or want a higher resolution version of the poster.