Lety León

[Alex Rives @alexrives]

A universal predictive model of the cell would dramatically accelerate science, allowing biologists to perform experiments digitally. Today we’re announcing a major partnership with the DOE and NIH. The goal of this partnership is to generate the data that will be needed to build an accurate model of the cell with artificial intelligence.

Isomorphic, Google DeepMind, and Meta are joining us as founding partners in the Virtual Biology Initiative. This is the beginning of a large scale coordinated effort to map cellular biology to power the development of digital models of life. Other leading scientific institutions and consortia including the Allen Institute, Broad Institute, Gladstone Institutes, the Human Cell Atlas, the Human Protein Atlas, the Wellcome Sanger Institute, as well as NVIDIA, are working together as part of this international scientific project.

Creating a predictive model of the cell is one of the most important challenges for the next decade of science. The insights that come from this could unlock a far greater understanding of disease, and open new paths for cures.

We invite the worldwide scientific community and other funders to join us in this effort.

[nature @Nature]

Scientists say they have made some of the first direct measurements of how long it takes an individual, ordinary protein to fold – and the results were surprising.

https://t.co/gs7UUNBLke

[William A. Wallace, Ph.D. @WilliamWallace]

Your gut has a circadian rhythm, and when you break it, everything downstream gets louder.

When your sleep, light exposure, and meal timing are misaligned, your GI tract doesn’t just get upset, it can shift into a different operating mode:

🔴 Barrier weakens
Claudin and occludin drop, permeability rises, and the gut becomes more reactive.

🔴 Digestion derails
Transporters, enzymes, and gastric acid lose their normal rhythm: carbs, proteins, and fats are absorbed differently.

🔴 Microbes flip behavior
Anti-inflammatory species fall, endotoxins rise, and host–microbiome communication breaks.

🔴 Motility goes off-cycle creating constipation, irregularity, or hypersensitivity.

On the other side of the graphic:
🟢 Aligned circadian rhythms restore stability: smoother motility, stronger barrier function, normal acid cycles, synchronized enzyme release, and a microbiome that behaves like it should.

This isn’t “sleep more, stress less.”
It’s biology: light, timing, and behavior controlling tight junctions, immune signaling, gastric motility, hormone rhythms, and microbial metabolites.

If you want better digestion, mood, immunity, and metabolic health…
you don’t just fix what you eat.
You fix when you live.

PMID: 40588189.

[Catéter Doble Jota @cateterdoblej]

Cuando un viajero llegó a Brevig Mission, todo el pueblo (eran menos de 100 habitantes) se alegró muchísimo. No era nada habitual recibir visitas allí… y menos en invierno #HistoriaMedicina #hilo 🧵⤵️

[Patóloca @PatolocaMD]

La charla más tranquila de los residentes de patología:

- Oigan, si no hubiera nada más que comer en el mundo, absolutamente nada más que los tumores que llegan a patología… Cuál se comerían ?

[Synchrotron SOLEIL @synchroSOLEIL]

✨ Retour sur l'École européenne #HERCULES2025
📅 Du 31 mars au 4 avril, nous avons eu le plaisir d’accueillir 24 jeunes chercheurs et chercheuses pour une semaine de formation intensive.
👏 Un grand merci à tous les intervenants et équipes de SOLEIL et bravo aux participants !

[Lety León @leonlety]

@lulu_catapano @wuvV9Sieb5EUpHr @ccp4_mx Thank you so much Lucrezia! ☺️ see you there!

[Lety León @leonlety]

@wuvV9Sieb5EUpHr @lulu_catapano @ccp4_mx Same question!!!!! 🙏🏽🙏🏽🙏🏽

[Estefani Gaytan @estefani_gaytan]

Attended the inspiring XXXIV Congreso Nacional de Bioquímica. Grateful for insightful discussion with Dr. Daisuke Kihara (@d_kihara) on structural biology's future perspectives. Thank you for sharing your expertise! #ProteinResearch #StructuralBiology #AIRevolution

[Daisuke Kihara @d_kihara]

Enjoyed the biochemistry society meeting of Mexico at Mazatlán. Great interaction with next generation scientists!

[Juanita Broaddrick @atensnut]

This video is hilarious. I still laugh myself crazy ever time it recirculates

[Lety León @leonlety]

Hola vecinos, tocando el tema del agua contaminada en @BJAlcaldia, ¿qué filtros de agua usan, cuál recomendarían?
Gracias!
@En_laDelValle

[Lucrezia Catapano @lulu_catapano]

We had such a great time at the SLAC Rapidata workshop teaching Coot and Moorhen. Leticia collected more Moorhen points than everyone else.. she beat me and Paul :)
#coot #slac #rapidata

[Lety León @leonlety]

Learning from the top experts!! @lulu_catapano

[Lety León @leonlety]

@ElizReginaa Buen pretexto pa volver

[Lety León @leonlety]

@Aureaibt Todo bieeeen?

[Mafer Bello @Mafeerr]

Estamos por inaugurar "Bello Aroma, Café & Restaurante" en Matías Romero 1355 por lo que estamos contratando baristas y cocineros.
Interesados favor de mandar su CV al correo [email protected] o comunicarse al 55 49374391 para que podamos contactarlos.
@En_laDelValle

[Borrachito 🥃 @borrachito]

Yo de tío, ayudando a solucionar problemas... 😅😂

[Lety León @leonlety]

@NobelPrize @e_rudino