Luis Graca

[Luis Graca @lgraca]

https://t.co/gES09E8Tqr
Happy to share our paper on Tfh specialization in antibody production on type-1 (virus) and type-2 immune responses (parasites, allergy). 1/11 #Tfhcells #germinalcentre #antibodies #immunology #bioinformatics. @kumar @imm @fmul @FilipaR @lgraca

[GIMM Institute @GIMM_Institute]

We are very happy with this recognition for such an amazing topic! Luís Graça, @gimm researcher, has several collaborations with one of the three laureates, Shimon Sakaguchi. "Generous and humble", that's how Luís describes him.

[Johanne Jacobsen @JoTraceyJa]

Wise words from Gabriel Victora, a scientist whose vision and insights are a constant source of inspiration 💫 https://t.co/JWfadgYR1J

[Vasco C Romao @romaovc]

Happy to present at #ACR24 our first data on scRNAseq and spatial transcriptomics in #Sjogrens. Minor salivary glands of early and late SjD revealed many different types of cell populations. More to come! Joint effort @lgraca lab @IMMolecular with #rheum & #path @ulssanta_maria

[CaixaResearch @CaixaResearchCA]

🤔🦠 Why is the flu vaccine less effective in older adults?

A new study co-led by #CaixaResearch investigator @lgraca (@GIMM_Institute) sheds light on this question.

Congratulations to the team on this work! 👏

https://t.co/nUiV0NZCUm

[Luis Graca @lgraca]

Happy to share the tweetorial of @saum_kmr, @YangLi_Lab on vaccine responsiveness in older adults. Timely as it is time to get the flu shot #VaccinesWork! I'm proud to be involved in the study! @GIMM_Institute @CaixaResearch

[Saumya Kumar @saum_kmr]

Glad to present our work on #flu #vaccine response in the elderly published in @ScienceAdvances. @Helmholtz_CiiM @YangLi_Lab. https://t.co/Q10VUi7aBM

[Saumya Kumar @saum_kmr]

Glad to present our work on #flu #vaccine response in the elderly published in @ScienceAdvances. @Helmholtz_CiiM @YangLi_Lab. https://t.co/Q10VUi7aBM

[Luis Graca @lgraca]

First day at our new institute. Today, @GIMM_Institute officially started. I found this welcome note to remind me that while my office remains the same, exciting times are ahead! #science #discovery

[Luis Graca @lgraca]

@YUmmunology Thank you @YUmmunology !

[Luis Graca @lgraca]

This work was only possible with support from several organizations: @CaixaResearch @fct_pt @PesquisaFapesp among others.

[Luis Graca @lgraca]

Functionally, sorted Tfh1 and Tfh2 behaved differently in vitro (that was reassuring!). Cytokine production and even help to class switching was consistent with their in-vivo function. 6/11

[Luis Graca @lgraca]

Thanks to @ElianePiaggio @jimena75656604 @margarida_gamac - critical collaborators in this work, and @CyrilPedia for discussions.

[Luis Graca @lgraca]

We used #MachineLearning (#elasticNet #lasso) to find the minimal number of genes that could discriminate the two subsets. We validated the genes with samples from different labs and real infections (virus and parasites) 5/11

[Luis Graca @lgraca]

Are there Tfh1 and Tfh2 cells? In human blood, Tfh subsets resembling Tfh1 and Tfh2 were described, but not confirmed in lymphoid tissue, and Tfh1-like cells appear to be suppressive (Groundbreaking work from @ueno). We investigated this issue in mice. 3/11

[Luis Graca @lgraca]

First, we immunized mice with type-specific adjuvants to obtain TCR-transgenic Tfh cells from draining lymph nodes in two different strains of mice. Their transcriptome showed Tfh cells differ from Th cells, and type-1 from type-2. Promising! 4/11 #ComputationalBiology

[Luis Graca @lgraca]

Once upon a time, immunologists believed Th1 and Th2 cells interact with B cells in the germinal centre inducing isotype switching (to IgG2a in virus infections and IgG1 with allergy/parasites). Work of @carola @dong etc… showed that only Tfh cells interact with B cells. 2/11

[Luis Graca @lgraca]

https://t.co/gES09E8Tqr
Happy to share our paper on Tfh specialization in antibody production on type-1 (virus) and type-2 immune responses (parasites, allergy). 1/11 #Tfhcells #germinalcentre #antibodies #immunology #bioinformatics. @kumar @imm @fmul @FilipaR @lgraca