Li Cao

[A. James Link @ajlinklab]

The latest Link lab paper is out @BiochemistryACS!: https://t.co/YtwobeGIjF This work, led by Angela Zhu, focuses on the cysimiditides, a new subfamily of #RiPPs. The cysimiditides include a tetracysteine motif that coordinates a zinc ion and a single aspartimide moiety.

[Princeton Materials Institute @PrincetonMSE]

In today's issue of @ScienceMagazine, PMI's Satish Myneni (@GeosciencesPU) and collaborators report findings that resolve a longstanding puzzle in the cycling of zinc, a vital element for ocean biological processes.

https://t.co/5ySUNffNBT

[A. James Link @ajlinklab]

The latest Link lab paper, led by @bsmchoi, is out today at ACS Chemical Biology @ACSBioMed! We carried out genome mining for graspetides with aspartimides and found nearly 1000 of them. https://t.co/o6eDXxX5fk

[A. James Link @ajlinklab]

The latest from the Link lab is out now @J_A_C_S! We describe a new family of #RiPPs, the imiditides, which are defined by an aspartimide modification. Great work led by recent PhD graduate Li Cao @li_cao_ : https://t.co/h3ejuvWfmD

[J. Am. Chem. Soc. @J_A_C_S]

Genome Mining and Discovery of Imiditides, a Family of RiPPs with a Class-Defining Aspartimide Modification | Journal of the American Chemical Society @ajlinklab @EPrinceton @PrincetonChem #Genome #Mining #Imiditides #RiPPs #Aspartimide @Peptide https://t.co/O2Aed1KFNz

[A. James Link @ajlinklab]

Out today @ACSCentSci is the latest from the Link lab: https://t.co/2AAGIT67o0! Lead author @alinathok screened a huge library of mutants of antimicrobial lasso peptide ubonodin and in collaboration with @ZhongyueY we built deep learning models to predict antimicrobial activity.

[A. James Link @ajlinklab]

Our latest paper on aspartimides in #RiPPs is out today @BiochemistryACS: https://t.co/HYeqtIhUX2! We explain the unusual stability of aspartimides in lasso peptides by determining the kinetics of each step in the reaction network.

[A. James Link @ajlinklab]

The latest paper from the Link lab is out today @J_A_C_S: https://t.co/FuTlsSsuJ8!  Led by @bsmchoi, with coauthors @li_cao_ and Hader Elashal, we carried out a detailed structural and biosynthetic analysis of a new #RiPP natural product amycolimiditide.

[A. James Link @ajlinklab]

The latest Link lab paper is out @NatureChemistry: https://t.co/dYkG0UcwUa! We solve the structure of a new graspetide #RiPP, fuscimiditide, and reconstitute its biosynthesis.  A big congrats to lead author Hader Elashal! (1/9)

[Mark Budde 🦕🏆 @markwbudde]

Primordium is now offering everyone the chance to sample our full-plasmid sequencing service for FREE - never use Sanger sequencing again! Please retweet this message and we'll DM you a coupon to sequence 5 ENTIRE PLASMIDS 100% FREE, no CC or PO needed. https://t.co/U4WeR2ftjL 5/

[A. James Link @ajlinklab]

Excited to share our latest publication now online @J_A_C_S: https://t.co/lokxE38YXJ. In this work we demonstrate a new PTM for lasso peptides: aspartimide. A thread! 1/10

[J. Am. Chem. Soc. @J_A_C_S]

A subset of lasso peptide biosynthetic gene clusters are reported, colocalized with genes that encode l-isoaspartyl methyltransferase homologues. A new function for these enzymes in the post-translational modification of lasso peptides is identified. https://t.co/0AC1vKBWbF