Ulf Ahlgren´s Research Group (Umeå University)

By bringing light to diabetes by optical (mesoscopic) imaging, our research aims at increasing our understanding of the pathophysiology of diabetes.

[Ulf Ahlgren´s Research Group (Umeå University) @lighttodiabetes]

Our study, “Illuminating the complete ß-cell mass of the human pancreas - signifying a new view on the islets of Langerhans”, is now published in Nature Communications (https://t.co/QXj5zNCcE6). #Diabetes #LSFM #OPT #Pancreas #isletsoflangerhans #Insulin #Glucagon #microscopy

[Signal Transduction & Metabolism Laboratory @STMLab_ULB]

We made the cover! Insulin-Binding Peptide Probes Provide a Novel Strategy for Pancreatic β-Cell Imaging. @ULBRecherche @NCP_frsFNRS @DiabetesAus @JDRFResearch #EFSD. Great collaboration with @lighttodiabetes and @pthorn14
https://t.co/5mCbgCPeBi

[Biomedical Picture of the Day BPoD @BPoD_s]

Individual islets reconstructed into the 3D #pancreas using a novel imaging approach. #WorldDiabetesDay2021 #WorldDiabetesDay Video and research by Max Hahn et al @lighttodiabetes @UmeaUniversity in @CommsBio. Read more on https://t.co/hRju1pH3EI with @MRV_LMS and @DrJohnAnkers

[Signal Transduction & Metabolism Laboratory @STMLab_ULB]

After a difficult time, we’re back on track and our 3rd manuscript of the year has been accepted for publication! 😀 A great collaboration with @lighttodiabetes & @pthorn14 “Insulin-binding peptide probes provide a novel strategy for pancreatic β-cell imaging” @ACSBioMed

[Davies Functional Genomics & Photobiology Lab @davies_lab]

Our new research paper is out in eNeuro: Distinct Opsin 3 (Opn3) Expression in the Developing Nervous System during Mammalian Embryogenesis https://t.co/huGE2DC0DX

[Communications Biology @CommsBio]

In this study, Hahn et al. present a method for visualizing the endocrine human pancreas in 3D and apply it to individuals with type 2 diabetes to reveal morphological differences in the endocrine pancreas. @lighttodiabetes @UmeaFor https://t.co/jSnmohM1wq

[Diabetes Wellness Sverige @DiabetesSverige]

Ny metod möjliggör detaljstudier av mänskliga organ i 3D https://t.co/ZAVzlOb4k6

[Ulf Ahlgren´s Research Group (Umeå University) @lighttodiabetes]

Our article is out @CommsBio! By the use of a 3D printed matrix we show how human organs (in our case the pancreas) can be specifically labelled, imaged by optical mesoscopic imaging techniques & reconstructed back together in 3D. https://t.co/1CP4RZZGqz
#LSFM #imaging @UmeaFor

[Daniel J Drucker @DanielJDrucker]

Reconstruction of the 3 dimensional anatomy of the human endocrine pancreas #islets @CommsBio https://t.co/Ng0Qi1o8Nh

[Communications Biology @CommsBio]

Streptozotocin-induced hyperglycemia primarily results from beta-cell dysfunction rather than ablatation in mice. This study provides insight into how the most widely used preclinical diabetes model works https://t.co/npOLRNcaZk

[Ulf Ahlgren´s Research Group (Umeå University) @lighttodiabetes]

Another paper out! Rapid Autofluorescence based 3D imaging of #PancreaticCancer . The video shows a human pancreatic cyst with vessels (red) and islets of Langerhans (green) imaged with the Ultramicroscope II.

https://t.co/KuJyqCPezY

[Umeå University @umeauniversity]

Congratulations Professor Emmanuelle Charpentier for the award of the 2020 Nobel Prize in Chemistry for the discovery of the gene-editing tool CRISPR-Cas9.
#EmmanuelleCharpentier #NobelPrize

https://t.co/ijILdp1RUm

[Cell Therapy News @celltherapynews]

🔎 Researchers from @UmeaUniversity show that hyperglycemic #Streptozotocin-treated mice still harbor a large pool of remaining β-cells but display pancreas-wide downregulation of glucose transporter type 2.

🔓 Open access https://t.co/umKiVL6wV4

[Ulf Ahlgren´s Research Group (Umeå University) @lighttodiabetes]

The video depicts a diabetic mouse pancreas and its different lobes (splenic lobe in green, gastric lobe in blue and duodenal lobe in yellow) imaged by Optical Projection Tomography. The surviving islets of Langerhans (in red) are dysfunctional.
https://t.co/xysdWRREod

[Pancreatic Cell News @PancreaticCell]

A really fascinating paper, and that image is just icing on the cake! 🎂

[Umea Centre for Molecular Medicine (UCMM) @UmeaFor]

Breaking news! UCMM would like to congratulate Prof. Ulf Ahlgren’s group on their excellent new paper published yesterday in Communications Biology (https://t.co/rdNWfGKXtZ). The image depicts a mouse pancreas imaged by Optical Projection Tomography (OPT).

[Ulf Ahlgren´s Research Group (Umeå University) @lighttodiabetes]

Now published! A new study in Nature's @CommsBio on the Streptozotocin diabetes mouse model, the most used diabetes model in rodents. Using advanced imaging, we show that the majority of islets remain, but surviving islets of Langerhans are dysfunctional.
https://t.co/xysdWRREod

[Ulf Ahlgren´s Research Group (Umeå University) @lighttodiabetes]

🔬Check out this stunning fluorescent slab of human pancreas in our 3D Microscope (Optical Projection Tomography). We make the sample transparent by adapting the refractive index, which allows to shine through the sample.

[Ulf Ahlgren´s Research Group (Umeå University) @lighttodiabetes]

Bringing light to diabetes on world diabetes day: 6 Lasers are used to analyse a pancreatic specimen in a Lavision Biotec 2nd generation Ultramicroscope.

[Ulf Ahlgren´s Research Group (Umeå University) @lighttodiabetes]

On world diabetes day we would like to raise awareness of the need for diabetes research and thank our funders for their support.