Biopsy with lung adenocarcinoma with the following histology. Three questions:
1. What is the predominant growth pattern?
2. What is the most likely targetable genetic alteration in this tumor?
#pathtwitter#pathology#lungpath
MPNSTs tend to show heterologous differentiation. Rhabdomyoblastic differentiation in an MPNST is called malignant Triton tumor. Awareness of the H&E and IHC features of this sarcoma is important. Read more in this IJSP paper -> https://t.co/oa8233cGEi
#PathTwitter#BSTPath
Grading appendiceal goblet cell adenocarcinoma is controversial. In practice it can cause difficulty for pathologists. This review documents interobserver variability and discusses the topic in detail. #gipathology https://t.co/TuVXirQyKZ
Research in Head and Neck Pathology identifies microsecretory adenocarcinoma (MSA) as a distinct salivary gland cancer with a unique genetic signature, MEF2C::SS18 fusion. Most cases show low-grade behavior, but some exhibit aggressive features.
https://t.co/Mcr1Vj4LkJ
Round cell sarcomas are a difficult area of #BSTPath IJSP comes to help🚨
In this excellent paper, Rekhi et al. present the clinicopathological features of 12 BCOR::CCNB3 sarcomas & beautifully review the existing literature.
Check it out here https://t.co/lRCmyQwFfP
#PathTwitter
Modern Molecular Profiling Recontextualizes the NRG/RTOG 0539 Trial and Reveals Hidden High-Risk and Radiotherapy Resistant Meningiomas
https://t.co/OvlENXs8U7
#HilaryBuckleyAward KAT6B::KANSL1 fusion–positive uterine sarcomas represent a newly emerging entity with striking morphological diversity, spanning low to high grade phenotypes and variable IHC expression.
Recognition and genomic testing are essential for accurate classification and management. #BAGP2026
Superficial CD34 positive fibroblastic tumour - An novel soft tissue tumour with indolent behaviour but alarming histology.
Learn more about morphologic subtypes, defining translocations (any guesses?), differential diagnoses and more from this systematic review of 190 cases out now in the JCP https://t.co/ELuSYv8mFS
@SumantaDas_7
International Consensus Guidelines for Diagnostic Criteria & Checklist for Future Studies for Minimally Invasive Carcinoma ex Pleomorphic Adenoma: HN CLEAR Initiative
Beadle et al
https://t.co/MZdbPDvB7C
#HeadNeckPathol#HNPJ#HeadandNeckPath#Pathology#ENTPath#PathologyTweet
Happy to see our @Pathoutlines article on PATZ1-rearranged sarcoma published 👇🏼
https://t.co/uziryeRBEN
3 things to remember about PATZ1-rearranged sarcoma:
💎Pseudoalveolar/(micro)cystic change->Swiss 🧀-like appearance
💎Hyalinized blood vessels
💎Rhabdomyoblastic differentiation often seen -- skeletal muscle marker expression tends to be accentuated around the pseudoalveolar spaces
Check out our article online (link above) 😊
#PathTwitter #BSTPath
New in #HumPathol: Clinicopathologic Spectrum of Renal-Pelvic Fibroepithelial Polyps: A Series of Five Patients with Emphasis on Mimicry of Malignancy. https://t.co/7AApTcBseh #pathology#PathTwitter#PathX#GIpath
A helpful well-illustrated review by an international team of gynaecological pathologists (Drs Wong, Talia and McCluggage from Hong Kong, Australia and the UK) of a group of very rare lesions. https://t.co/ZE8u7mMVCF
Molecularly Variant Synovial Sarcoma of the Lower Lip: MN1::SSX1 Fusion as a Diagnostic Pitfall in Head & Neck
Scott Kuan-Wen Wang, Julia Yew, Akshay V. Patel & Srinivas Mandavilli
https://t.co/VOHFon9HhL
#HeadNeckPathol#HNPJ#HeadandNeckPath#Pathology#ENTPath#PathologyTweet
Please check out this excellent review of cholangiocarcinoma by top expert Professor Yoh Zen, from Kings College Hospital, London. It summarises contemporary classification systems, molecular changes, pitfalls in interpretation, and differential diagnosis. https://t.co/EiVN5Fdsfl