Tamara Lotan, MD

Molecular pathologist with focus on prostate cancer. Johns Hopkins University.

[Kaushal Asrani @AsraniKaushal]

Excited to finally share our latest study on #TranslocationRCC #PEComas @NatureComms!
We generated the first ever, murine transgenic kidney tumor models of SFPQ-TFE3 - the most common MiT/TFE gene fusion implicated in both, tRCC and PEComas (Perivascular Epitheloid neoplasms).
We describe a novel role for this fusion in regulating #mTORC1-driven lineage plasticity, with transcriptional downregulation of critical nephric lineage transcription factors like PAX8, that perfectly recapitulate human renal PEComas.
Additionally, we nominate the lysosomal V-ATPase complex as a central regulator of mTORC1 activity in tRCC, and a target-rich environment for therapeutic intervention in this deadly disease.
Grateful to all the co-authors, collaborators, reviewers, editors and funding sources who made this study possible! @adriannaamendes @LotanLab @eddieimada @MasayaBaba2 @terry_watnickmd @WMarstonLinehan @PeterArgani @yasserged @rmelias2 @nirmishsingla @allaf_mo @Joeyswings @KidneyCancer @kidneycan @CDMRP
https://t.co/3kcO1TWmNI

[Swati Bhardwaj, MD @DrSwatiBhardwaj]

Dr. Lotan’s @LotanLab fellows/trainees (former and current) in one picture — grateful and proud to be part of this incredible group! Privileged to learn from her #PathTwitter #GUPath #USCAP2025 @JHUPath @UCSFPath @harsimarbhatia

[Swati Bhardwaj, MD @DrSwatiBhardwaj]

Come stop by our poster (No. 179) on the Association of Histologic Subtype, Genomic Driver Mutation, and mTORC1 Biomarker Expression in TSC1/2/MTOR-Altered Tumors! Privileged to get the opportunity to work with Dr. Lotan! @LotanLab
#GUPath @TheUSCAP #USCAP2025

[Ralph Hruban @RalphHruban]

Congratulations Johns Hopkins resident Eric Young- winner of the 2025 abstract award from the Pancreatobiliary Society at the 2025 USCAP meetings!

[Gladell Paner, MD @GladellPaner]

Joint GUPS and ISUP Expert Consultation on Intraductal Carcinoma of the #Prostate. Boston, MA USA March 22, 2025.

Thank you Dr. Rajal Shah @rajalbshah, Dr. Glen Kristiansen, @GU_Path_Society and @IntSocUropath! It’s a great moment in our field.

So proud of #GUPath! 🙏🏻

[Johns Hopkins Pathology @JHUPath]

✨Congratulations to our incoming class of PGY-1s!✨

We are so excited to be welcoming you to the Johns Hopkins Pathology family! 🔬

#pathmatch2025 #pathology #johnshopkins #johnshopkinsmedicine #residency

[Samson W. Fine, MD @rovingatuscap]

GUPS @GU_Path_Society Poster Walks return for #USCAP2025 featuring an outstanding line-up of international experts in #gupath

Especially geared to trainees, Poster Walk leaders will provide context, thematic discussion, and curated knowledge to enhance your learning experience!

[Samson W. Fine, MD @rovingatuscap]

Excited to Join @JHUPath Hopkins Pathology for a Career Development Session on How To Prepare for and Navigate National Meetings in advance of #USCAP2025 - thx @LotanLab for the invite!

[Samson W. Fine, MD @rovingatuscap]

Excited for the @GU_Path_Society Companion Society Meeting at #USCAP2025 featuring talks on:

#prostatecancer ML/AI
#kidneycancer diagnostics
#urothelialcancer biomarkers

[Tamara Lotan, MD @LotanLab]

So thrilled to join @brady_urology and to work with @allaf_mo and the great team in Urology!

[Mohamad Allaf @allaf_mo]

THRILLED to announce @LotanLab 5th Director of Research @brady_urology in footsteps of Don Coffey to transform care & mentor leaders! 1st woman to hold position. Dr. Pienta to serve as Special Advisor to Provost & advance to Director Innovation and Strategy! CONGRATULATIONS!

[Denis Wirtz @deniswirtz]

Hopkins is recruiting 30 Bloomberg Distinguished Professors in AI + X

(X = astrophysics, cancer, neuroscience, genomics, social sciences, etc.)

https://t.co/xqH84pFcrP

22 of these 30 will be organized in clusters:

[Joey's Wings Foundation @Joeyswings]

Trailblazer Award – $75,000 in partnership with @KidneyCancer was granted to Dr. Kaushal Asrani of Johns Hopkins University School of Medicine! This research project: Therapeutic Targeting of EGFR and HER2 in Translocation Renal Cell Carcinoma.

[dahlia kurtz ✡︎ דליה קורץ @DahliaKurtz]

This is October 7. And you must bear witness.

The KiIIing Roads is a raw documentary of that Black Saturday — with about 50% of never-before-seen-footage.

Yes. This will punch you in your heart — over and over.

The filmmaker Igal Hecht has made it free for all.

Please share.

[Kaushal Asrani @AsraniKaushal]

Excited to share our joint review with @NicolaAlesi @LisaHenske @LotanLab on the ever-expanding role of the MiT/TFE factors as upstream activators of mTORC1 and drivers of renal tumorigenesis #TSC #BHD #tRCC #TFEopathies #mTOR

[Scott Eggener @uroegg]

Hard to imagine a future without AI pathology:
- outperforms high-quality pathologists
- provides the % of Gleason pattern 3, 4, and 5

Predicting prostate cancer grade reclassification on active surveillance using a deep Learning-Based grading algorithm https://t.co/sHlZYsl10q

[International Society of Urological Pathology @IntSocUropath]

Join the #ISUP “Consensus Conference on GU Precursor Lesions,” open to all in pathology, urology, and oncology. #ISUPItaly2024 🇮🇹

Complete the pre-meeting survey from all 5️⃣ working groups. Your input matters!

🔗: https://t.co/g0jS9RVWoo
🗳️ Voting Period Ends: June 30

[The Hill @thehill]

House launches email address to report college antisemitism amid investigation https://t.co/9ziNMTMA8r

[Alex Thompson @AlexThomp]

WH spokesperson Andrew Bates responds to this hearing yesterday:
"It’s unbelievable that this needs to be said: calls for genocide are monstrous and antithetical to everything we represent as a country."

[JCO Precision Oncology @JCOPO_ASCO]

.@LotanLab et al. highlight challenges associated with commercial molecular assays in evaluating MLH1-deficient prostate tumors ➡️ https://t.co/lkt9IEXjzK #pcsm

[Tamara Lotan, MD @LotanLab]

@GladellPaner @drmehrarohit We have a new mouse model of SFPQ-TFE3 carcinoma with very similar bi-phasic pattern—would be interested to know fusion partner in this case!