Lukas Junk

Synthetic medicinal chemist at HIPS/UdS in Saarbrücken with a focus on peptidic natural products. Also skateboarder and wannabe musician

[BioWorld Science @BioWorldScience]

Degradation strategy prevents survival of tuberculosis bacterium (free w/ registration) https://t.co/8C5QiFDB0g

[Lukas Junk @lukasjunk]

@Real_Dr_Kessler synthesis was rather straightforward and fun since we just had to dimerize the precursors... but being in the way-beyond-Ro5 space (MW > 2000) is not so fun when trying to optimize PK properties 🥲

[Lukas Junk @lukasjunk]

The second half of our homo-BacPROTAC story is now out in @CellCellPress (even before the other half is accepted)! @DHoi93 walks you through the awesome biology behind this study.
Huge thanks to everyone involved @clausen_lab @ChemHaWei @SchmiedelVolker @somrajguha03 & many more

[David Hoi @DHoi93]

Excited to share our recent work from the @clausen_lab published in @CellPressNews as part 2 of the BacPROTAC story. Here we use targeted protein degradation as an antibiotics strategy to induce self-elimination of essential mycobacterial Clp proteins. https://t.co/8AqzNw7tSY

[Lukas Junk @lukasjunk]

@DHoi93 @Boehringer it was a pleasure working with you folks at IMP, knowing our compounds are in such talented hands :)

[Lukas Junk @lukasjunk]

@MximilianBauer @HeretschPhilipp @thiemechemistry @LeibnizUni glückwunsch! :)

[Lukas Junk @lukasjunk]

@Carbolution hahahahatu

[Lukas Junk @lukasjunk]

@HartungIngo In den Mitteilungseinstellungen (unter iOS ganz unten) auch Testalarms via Cell Broadcast erlaubt?

[Laborjournal @Lab_Journal]

"BacPROTAC" ist unser "Stichwort des Monats"!
— Ein Team um @clausen_lab (@IMPvienna) & Markus Kaiser (@unidue) übertrug das Konzept des PROTAC-intiierten Proteinabbaus auf Bakterien – und macht damit die Entwicklung neuartiger #Antibiotika möglich … 👉 https://t.co/MXYUMaZVRO

[Lukas Junk @lukasjunk]

@agrossfield @leslievosshall @HHMINEWS @ardemp https://t.co/lvTfovGBrw will turn any doi into a 6-letter one. saw it once in a talk and it just makes sense

[Lukas Junk @lukasjunk]

@Carbolution @janboehm gehört aber zum „Weinanbaugebiet Mosel“, früher Mosel-Saar-Ruwer. Der Fehler hat also seine Gründe https://t.co/NYuFl7qLPm

[Lukas Junk @lukasjunk]

@LSE_editors Thank you so much! The editing and suggestions from @MilkaKostic helped a lot in streamlining the story.

[Lukas Junk @lukasjunk]

@rs_mito Probably nothing. The cyclomarins are highly selective for mycobacterial ClpC1, we don't even see any effects on other gram-positive or gram-negative bacteria

[Lukas Junk @lukasjunk]

I’m excited to share our work on the development of bacterial PROTACs acting against Mycobacterium tuberculosis :) Our "homo-BacPROTACs" are able to kill drug-resistant Mtb by inducing the degradation of ClpC1, an essential protein in mycobacteria.
https://t.co/89VPJSNTNv

[Lukas Junk @lukasjunk]

@christine_m_le thanks Christine :) I thought so since I heard he was a postdoc in the Lautens lab. The chemistry-world is rather small after all

[Lukas Junk @lukasjunk]

This is the first time that TPD and the BacPROTAC concept have been used to construct antibiotics. It’s a totally new way of killing bacteria. Big thanks go out to everyone involved and the great teams at
@Saar_Uni, @Boehringer, @IMPvienna. @clausen_lab @somrajguha03 @ChemHaWei

[Lukas Junk @lukasjunk]

In an SAR study of a library of homo-BacPROTACs, we investigated their solubility, permeability, binding and antibacterial properties. These findings pave the way for further improvements on the way to make BacPROTACs feasible as drugs against TB.

[Lukas Junk @lukasjunk]

Upon dimerization, we observed a jump in MIC against Mtb by one order of magnitude! The degradation of the target protein leads to an efficient killing of the bacteria. It even kills multi-drug-resistant Mtb and those residing in macrophages.

[Lukas Junk @lukasjunk]

Guiding you through the paper:
We connected two cyclomarin units using click chemistry or olefin metathesis to make BacPROTACs that hijack the unfoldase ClpC1 and cause it to be degraded by its own associated protease ClpP1P2.

[Lukas Junk @lukasjunk]

@Titz_Lab höchswahrscheinlich spacex Starlink Satelliten die noch nicht an ihrer finalen Destination sind

[Lukas Junk @lukasjunk]

@liz_munday 🤤